Abstract:
BACKGROUND:Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. METHODS:We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. RESULTS:After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation. CONCLUSIONS:The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Ruan GP,Yao X,Yang SJ,Wang JX,Shu F,Li ZA,Liu JF,Pang RQ,Pan XHdoi
10.1155/2014/530501subject
Has Abstractpub_date
2014-01-01 00:00:00pages
530501eissn
2314-8861issn
2314-7156journal_volume
2014pub_type
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