Abstract：
:Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify targets for therapeutic interventions. Specific molecular strategies to overcome human anti-pig NK cell responses include (1) blocking of the molecular events leading to recruitment (chemotaxis, adhesion, and transmigration), (2) expression of human MHC class I molecules on pECs that inhibit NK cells, and (3) elimination or blocking of pig ligands for activating human NK receptors. The potential of cell-based strategies including tolerogenic dendritic cells (DC) and regulatory T cells (Treg) and the latest progress using transgenic pigs genetically modified to reduce xenogeneic NK cell responses are discussed. Finally, we present the status of phenotypic and functional characterization of nonhuman primate (NHP) NK cells, essential for studying their role in xenograft rejection using preclinical pig-to-NHP models, and summarize key advances and important perspectives for future research.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Puga Yung G,Schneider MKJ,Seebach JDdoi
10.1155/2017/4627384subject
Has Abstractpub_date
2017-01-01 00:00:00pages
4627384eissn
2314-8861issn
2314-7156journal_volume
2017pub_type
杂志文章,评审abstract：:C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) i...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/450695
更新日期：2015-01-01 00:00:00
abstract：:Accumulating evidence has pointed out that metastasis is the leading cause of death in several malignant tumor, including CRC. During CRC, metastatic capacity is closely correlated with reprogrammed energy metabolism. Mitochondrial Pyruvate Carrier 1 (MPC1), as the carrier of transporting pyruvate into mitochondria, l...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/8340329
更新日期：2020-08-19 00:00:00
abstract：:Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/931574
更新日期：2015-01-01 00:00:00
abstract：:We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; betwee...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/809389
更新日期：2014-01-01 00:00:00
abstract：:Peroxisome proliferator-activated receptors (PPAR gamma-2) and beta-3-adrenergic receptors (ADRB3) are involved in the risk of hypertension. But their exact role in blood pressure modulation in patients with connective tissue diseases (CTD) is still not well defined. In this study, 104 patients with CTD and 103 gender...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/7509608
更新日期：2020-02-03 00:00:00
abstract：:Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/167089
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abstract：:Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/4097642
更新日期：2016-01-01 00:00:00
abstract：:Latent tuberculosis infection (LTBI) is evidence of immunological control of tuberculosis. Dormancy survival regulator (DosR) regulon-encoded proteins may have a role in the maintenance of LTBI. T cell responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were found to be most frequent among...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2017/1593143
更新日期：2017-01-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/4384696
更新日期：2020-08-04 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/8835393
更新日期：2020-12-30 00:00:00
abstract：:Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pat...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/376197
更新日期：2015-01-01 00:00:00
abstract：Objective:Safflower has antioxidant and anti-inflammatory activities. The two forms of preparations for safflower which are widely used in China are injection and decoction. The first step of the process for preparing an injection involves extracting safflower with water, which actually yields a decoction. This study i...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/1018274
更新日期：2019-05-06 00:00:00
abstract：:Ischemia/reperfusion injury (IRI) remains a major problem in organ transplantation, which represents the main cause of graft dysfunction posttransplantation. Hepatic IRI is characterized by an excessive inflammatory response within the liver. Mesenchymal stem cells (MSCs) have been shown to be immunomodulatory cells a...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/7283703
更新日期：2018-12-03 00:00:00
abstract：:Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) gene encodes the A20 protein, an important negative feedback regulator of the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) pathway. A coding TNFAIP3 variant, namely rs2230926, has been previously linked to B cell non-Hodgkin's lymphoma (...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/6923213
更新日期：2018-12-19 00:00:00
abstract：:Phosphotyrosine phosphatases (PTPs) constitute a complex family of enzymes that control the balance of intracellular phosphorylation levels to allow cell responses while avoiding the development of diseases. Despite the relevance of CD4 T cell polarisation and effector function in human autoimmune diseases, the expres...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2017/8701042
更新日期：2017-01-01 00:00:00
abstract：:Candida albicans is a fungus that is an opportunistic pathogen of humans. Normally, C. albicans exists as a harmless commensal and does not trigger inflammatory responses by resident macrophages in skin mucosa, which may be caused by a tolerance of skin macrophage to C. albicans. IL-34 is a recently discovered cytokin...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/328146
更新日期：2015-01-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/2624981
更新日期：2018-08-14 00:00:00
abstract：:Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incomple...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/108451
更新日期：2015-01-01 00:00:00
abstract：:Chlorogenic acid (CA) is a phenolic compound commonly found in human plant-based diets. CA is the main component of many traditional Chinese medicine preparations, and in recent years, it has been found to have hypoglycemic, hypolipidemic, anti-inflammatory, antioxidant, and other pharmacological properties. Specifica...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2020/9680508
更新日期：2020-05-28 00:00:00
abstract：:Immune activation plays a significant role in the disease progression of HIV. Microbial products, especially bacterial lipopolysaccharide (LPS), contribute to immune activation. Increasing evidence indicates that T lymphocyte homeostasis disruptions are associated with immune activation. However, the mechanism by whic...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/202738
更新日期：2015-01-01 00:00:00
abstract：:Reports suggesting a pathogenic role of autoantibodies directed against glutamic acid decarboxylase 65 (GAD65Abs) in cerebellar ataxias (CAs) are reviewed, and debatable issues such as internalization of antibodies by neurons and roles of epitopes are discussed. GAD65 is one of two enzymes that catalyze the conversion...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/2913297
更新日期：2017-01-01 00:00:00
abstract：:Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2019/1603758
更新日期：2019-04-16 00:00:00
abstract：:Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2020/6193407
更新日期：2020-04-30 00:00:00
abstract：:Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2020/4582612
更新日期：2020-09-25 00:00:00
abstract：:Schmallenberg virus (SBV), discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expressio...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/160316
更新日期：2014-01-01 00:00:00
abstract：:The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/747645
更新日期：2015-01-01 00:00:00
abstract：:Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues. Their role in tumor invasion and metastasis is often discussed. In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 t...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/8519648
更新日期：2016-01-01 00:00:00
abstract：:Immune cell therapy has emerged as a promising approach to treat malignancies that were up until recently only treated on a palliative basis. Chimeric antigen receptor- (CAR-) modified T lymphocytes (T cells) in particular have proven to be very effective for certain hematological malignancies. The production of CAR T...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/3616120
更新日期：2019-09-04 00:00:00
abstract：:Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/4892473
更新日期：2018-08-12 00:00:00
abstract：:Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN f...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/4320195
更新日期：2018-02-11 00:00:00
