Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function.

abstract：:Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...

journal_title：Journal of immunology research

authors： Liao H,Li Y,Zhang X,Zhao X,Zheng D,Shen D,Li R

更新日期：2020-08-27 00:00:00

abstract：:Collectin-12 (collectin placenta 1, CL-P1, or CL-12) is a newly identified pattern recognition molecule of the innate immune system. Recent evidences show that CL-12 plays important roles not only in innate immune protection against certain clinically important pathogens but also in scavenging of host molecules, leuko...

journal_title：Journal of immunology research

authors： Zhang J,Li A,Yang CQ,Garred P,Ma YJ

更新日期：2019-07-29 00:00:00

abstract：:Immune activation plays a significant role in the disease progression of HIV. Microbial products, especially bacterial lipopolysaccharide (LPS), contribute to immune activation. Increasing evidence indicates that T lymphocyte homeostasis disruptions are associated with immune activation. However, the mechanism by whic...

journal_title：Journal of immunology research

authors： Zhang GH,Wu RD,Zheng HY,Zhang XL,Zhang MX,Tian RR,Liu GM,Pang W,Zheng YT

更新日期：2015-01-01 00:00:00

abstract：:Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the p...

journal_title：Journal of immunology research

authors： Arreola R,Alvarez-Herrera S,Pérez-Sánchez G,Becerril-Villanueva E,Cruz-Fuentes C,Flores-Gutierrez EO,Garcés-Alvarez ME,de la Cruz-Aguilera DL,Medina-Rivero E,Hurtado-Alvarado G,Quintero-Fabián S,Pavón L

更新日期：2016-01-01 00:00:00

abstract：:Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or...

journal_title：Journal of immunology research

authors： Bagatini MD,Dos Santos AA,Cardoso AM,Mânica A,Reschke CR,Carvalho FB

更新日期：2018-08-12 00:00:00

abstract：:Peripheral CD4/CD8 double-positive (DP) T cells are associated with autoimmune disorders, cancer, and viral infection. However, the relationship between organ transplantation and DP T cells is unclear. Here, we examined the functional characteristics of peripheral DP T cells and analyzed their significance with respec...

journal_title：Journal of immunology research

authors： Choi YJ,Park HJ,Park HJ,Jung KC,Lee JI

更新日期：2018-07-10 00:00:00

abstract：:Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incomple...

journal_title：Journal of immunology research

authors： Mori G,D'Amelio P,Faccio R,Brunetti G

更新日期：2015-01-01 00:00:00

abstract：:TACI is a membrane receptor of BAFF and APRIL, contributing to the differentiation and survival of normal B cells. Although malignant B cells are also subjected on TACI signaling, there is a remarkable intradisease and interindividual variability of TACI expression in B-cell malignancies. The aim of our study was to e...

journal_title：Journal of immunology research

authors： Mamara A,Germenis AE,Kompoti M,Palassopoulou M,Mandala E,Banti A,Giannakoulas N,Speletas M

更新日期：2015-01-01 00:00:00

abstract：:Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together. Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-larg...

journal_title：Journal of immunology research

authors： László I,Trásy D,Molnár Z,Fazakas J

更新日期：2015-01-01 00:00:00

abstract：Introduction:Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evid...

journal_title：Journal of immunology research

authors： Talotta R,Sarzi-Puttini P,Atzeni F

更新日期：2019-01-06 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 ...

journal_title：Journal of immunology research

authors： Mi L,Zhu S,Cai J,Xu S,Xue Z,Lu H

更新日期：2020-10-31 00:00:00

abstract：Objective:This study aimed to investigate the correlation of CD4+/PD-1+ or CD4+/PD-1- tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods:A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed ce...

journal_title：Journal of immunology research

authors： Zhao YJ,Zhang J,Shi F,Hu ZP,Wu JP,Wu GJ,Wang RB,Zhou Q,Chang H,Li YN,Song QK

更新日期：2018-07-04 00:00:00

abstract：:Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great effort...

journal_title：Journal of immunology research

authors： Lambraño J,Curtidor H,Avendaño C,Díaz-Arévalo D,Roa L,Vanegas M,Patarroyo ME,Patarroyo MA

更新日期：2019-12-30 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...

journal_title：Journal of immunology research

authors： Feng Q,Liu D,Lu Y,Liu Z

更新日期：2020-04-30 00:00:00

abstract：:We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; betwee...

journal_title：Journal of immunology research

authors： Li J,Leng X,Li Z,Ye Z,Li C,Li X,Zhu P,Wang Z,Zheng Y,Li X,Zhang M,Tian XP,Li M,Zhao J,Zhang FC,Zhao Y,Zeng X

更新日期：2014-01-01 00:00:00

abstract：:Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment. Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance ...

journal_title：Journal of immunology research

authors： Nau D,Altmayer N,Mattner J

更新日期：2014-01-01 00:00:00

abstract：:The predominant distribution of γ δ T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the "guards" to contact external environment (like allergens) and to contribute to immune surveillance, as well as "vanguards" to participate in initiating mucosal inflammation. Therefore, γ δ T cel...

journal_title：Journal of immunology research

authors： Zheng R,Yang Q

更新日期：2014-01-01 00:00:00

abstract：:Amiselimod (MT-1303) is a novel and selective sphingosine 1-phosphate receptor-1 (S1P1) modulator with a more favorable cardiac safety profile than other S1P1 receptor modulators. In this study, we evaluated the effects of MT-1303 on the progression of lupus nephritis in two well-known murine systemic lupus erythemato...

journal_title：Journal of immunology research

authors： Sugahara K,Maeda Y,Shimano K,Murase M,Mochiduki S,Takemoto K,Kakimoto T,Utsumi H,Oshita K,Kataoka H

更新日期：2019-12-23 00:00:00

abstract：:The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield diff...

journal_title：Journal of immunology research

authors： Arreola R,Quintero-Fabián S,López-Roa RI,Flores-Gutiérrez EO,Reyes-Grajeda JP,Carrera-Quintanar L,Ortuño-Sahagún D

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). METHOD:108 SLE patients and 42 healthy controls were recruited in this study. The expression of mM...

journal_title：Journal of immunology research

authors： Zhu H,Sun X,Zhu L,Hu F,Shi L,Li Z,Su Y

更新日期：2014-01-01 00:00:00

abstract：:Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enh...

journal_title：Journal of immunology research

authors： Wu Z,Nakanishi H

更新日期：2015-01-01 00:00:00

abstract：:Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...

journal_title：Journal of immunology research

authors： Richard SA,Kampo S,Hechavarria ME,Sackey M,Buunaaim ADB,Kuugbee ED,Anabah TW

更新日期：2020-09-25 00:00:00

abstract：:Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its derivative 5-aza-2'-deoxy...

journal_title：Journal of immunology research

authors： Landman S,Cruijsen M,Urbano PCM,Huls G,van Erp PEJ,van Rijssen E,Joosten I,Koenen HJPM

更新日期：2018-04-15 00:00:00

abstract：:The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate t...

journal_title：Journal of immunology research

authors： Peng S,Wei P,Lu Q,Liu R,Ding Y,Zhang J

更新日期：2018-09-18 00:00:00

abstract：:Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tiss...

journal_title：Journal of immunology research

authors： Brietzke A,Korytář T,Jaros J,Köllner B,Goldammer T,Seyfert HM,Rebl A

更新日期：2015-01-01 00:00:00

abstract：:Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9). After activation, these enzymes cleave extracellular matrix components and cytokines and thus...

journal_title：Journal of immunology research

authors： Qiu Z,Chen J,Xu H,Van den Steen PE,Opdenakker G,Wang M,Hu J

更新日期：2014-01-01 00:00:00

abstract：:A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragali and Radix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation ...

journal_title：Journal of immunology research

authors： Zhou J,Li X,Deng P,Wei Y,Liu J,Chen M,Xu Y,Zhang D,Zhu L,Lou L,Dong B,Jin Q,Chai L

更新日期：2017-01-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...

journal_title：Journal of immunology research

authors： Guo X,Chen D,An S,Wang Z

更新日期：2020-08-04 00:00:00

abstract：Background:Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis. Me...

journal_title：Journal of immunology research

authors： Du X,Chen Y,Zhu J,Bai Z,Hua J,Li Y,Lv H,Zhang G

更新日期：2020-09-01 00:00:00

abstract：:Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safet...

journal_title：Journal of immunology research

authors： Costa APF,Cobucci RNO,da Silva JM,da Costa Lima PH,Giraldo PC,Gonçalves AK

更新日期：2017-01-01 00:00:00