Abstract：
:Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9). After activation, these enzymes cleave extracellular matrix components and cytokines and thus may contribute to shock syndrome development. MMP inhibitors have been suggested as immunotherapy of endotoxin shock. However, little is known about the therapeutic time window of MMP inhibition. Here, a sublethal endotoxin shock mouse model was used to evaluate the effect of an MMP inhibiting peptide (P2) after intravenous or intraperitoneal injection and to study the time window between LPS and inhibitor injections. With the use of a specific ELISA the plasma P2 concentrations were monitored. Whereas we corroborated the treatment strategy of MMP targeting in endotoxin shock with a new inhibitor, we also demonstrated that the time window, within which effective MMP inhibition increased the survival rates, is rather limited.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Qiu Z,Chen J,Xu H,Van den Steen PE,Opdenakker G,Wang M,Hu Jdoi
10.1155/2014/747426subject
Has Abstractpub_date
2014-01-01 00:00:00pages
747426eissn
2314-8861issn
2314-7156journal_volume
2014pub_type
杂志文章abstract：:Reports suggesting a pathogenic role of autoantibodies directed against glutamic acid decarboxylase 65 (GAD65Abs) in cerebellar ataxias (CAs) are reviewed, and debatable issues such as internalization of antibodies by neurons and roles of epitopes are discussed. GAD65 is one of two enzymes that catalyze the conversion...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/2913297
更新日期：2017-01-01 00:00:00
abstract：Background:Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method:Peripheral blood mononuclear cell...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/6261814
更新日期：2020-12-23 00:00:00
abstract：:Mesothelin (MSLN) is a 40-kDa cell differentiation-associated glycoprotein appearing with carcinogenesis and is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas, while its expression in normal tissue is limited to mesothelial cells lining ...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/268172
更新日期：2015-01-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the exp...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/492872
更新日期：2014-01-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/2624981
更新日期：2018-08-14 00:00:00
abstract：:Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in ...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/1462098
更新日期：2019-11-14 00:00:00
abstract：:This work is aimed at investigating the effect of melittin on identified key genes in bladder cancer (BC) and further providing a theoretical basis for BC treatment. GSE35014 downloaded from the Gene Expression Omnibus (GEO) database was used to screen differentially expressed genes (DEGs) in BC cells and control. Res...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/5038172
更新日期：2018-05-03 00:00:00
abstract：:Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incomple...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/108451
更新日期：2015-01-01 00:00:00
abstract：:Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods. Blood was collected for DNA analysis from patients with chronic HCV infection or evidence of spontaneous ...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/6530436
更新日期：2016-01-01 00:00:00
abstract：:To examine human gene expression during uncomplicated P. falciparum malaria, we obtained three samples (acute illness, treatment, and recovery) from 10 subjects and utilized each subject's recovery sample as their baseline. At the time of acute illness (day 1), subjects had upregulation of innate immune response, cyto...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/162639
更新日期：2015-01-01 00:00:00
abstract：:Toll/IL-1R-domain-containing adaptor-inducing IFN-β (TRIF) is an important adaptor for TLR3- and TLR4-mediated inflammatory signaling pathways. Recent studies have shown that TRIF plays a key role in vessel inflammation and atherosclerosis; however, the precise mechanisms are unclear. We investigated the mechanisms of...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/6249085
更新日期：2018-06-07 00:00:00
abstract：:Pregnancy is an immunological enigma where paternal antigens are present at the fetomaternal interface. What regulates the local immunotolerance, which is necessary to prevent rejection of the conceptus, is still under strong investigation. Gamma/delta T cells are believed to play a role in the local regulation of thi...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/3836942
更新日期：2019-05-20 00:00:00
abstract：:Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great effort...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/3832513
更新日期：2019-12-30 00:00:00
abstract：Objective:Safflower has antioxidant and anti-inflammatory activities. The two forms of preparations for safflower which are widely used in China are injection and decoction. The first step of the process for preparing an injection involves extracting safflower with water, which actually yields a decoction. This study i...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/1018274
更新日期：2019-05-06 00:00:00
abstract：:The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. IL-7 is a cytokine whose ability to stimulate IL-17 production in both innate and adaptive immunity cells has made it a promising target not only for a better understanding o...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2019/7453236
更新日期：2019-05-29 00:00:00
abstract：:The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate t...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/7245956
更新日期：2018-09-18 00:00:00
abstract：:We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD). Moreover, the effect of DCA on inflammasome activation is mainly mediated t...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/2481418
更新日期：2018-05-09 00:00:00
abstract：Objective:Systemic lupus erythematosus (SLE) is an autoimmune systemic disease and its pathogenesis has not yet been completely clarified. Patients with SLE show a deranged lipid metabolism, which can contribute to the immunopathogenesis of the disease and to the accelerated atherosclerosis. Resolvin D1 (RvD1), a produ...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/5264195
更新日期：2018-10-21 00:00:00
abstract：:Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear th...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/1467538
更新日期：2018-06-11 00:00:00
abstract：:Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/931574
更新日期：2015-01-01 00:00:00
abstract：:Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically. Cross talk between the innate and adaptive immune response may be requisite t...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/3145742
更新日期：2017-01-01 00:00:00
abstract：:Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoa...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2014/632307
更新日期：2014-01-01 00:00:00
abstract：:The predominant distribution of γ δ T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the "guards" to contact external environment (like allergens) and to contribute to immune surveillance, as well as "vanguards" to participate in initiating mucosal inflammation. Therefore, γ δ T cel...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2014/963484
更新日期：2014-01-01 00:00:00
abstract：:A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment and expansion and calcium imaging of cultured cells challenged by mechanical and acetylcholine (ACh) stimula...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/232659
更新日期：2014-01-01 00:00:00
abstract：:Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/3651743
更新日期：2018-06-14 00:00:00
abstract：:The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor metabolic activity. The purpose of this review was to examine origina...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/4587520
更新日期：2017-01-01 00:00:00
abstract：:Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment. Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2014/546596
更新日期：2014-01-01 00:00:00
abstract：:Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/1798795
更新日期：2020-10-17 00:00:00
abstract：:Peroxisome proliferator-activated receptors (PPAR gamma-2) and beta-3-adrenergic receptors (ADRB3) are involved in the risk of hypertension. But their exact role in blood pressure modulation in patients with connective tissue diseases (CTD) is still not well defined. In this study, 104 patients with CTD and 103 gender...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/7509608
更新日期：2020-02-03 00:00:00
abstract：:Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pat...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/376197
更新日期：2015-01-01 00:00:00
