Anti-CD3 antibody treatment induces hypoglycemia and super tolerance to glucose challenge in mice through enhancing glucose consumption by activated lymphocytes.

abstract：:Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control gro...

journal_title：Journal of immunology research

authors： Akarsu S,Ozbagcivan O,Semiz F,Aktan S

更新日期：2017-01-01 00:00:00

abstract：:HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is d...

journal_title：Journal of immunology research

authors： Castelli EC,Veiga-Castelli LC,Yaghi L,Moreau P,Donadi EA

更新日期：2014-01-01 00:00:00

abstract：:The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early intervent...

journal_title：Journal of immunology research

authors： Ranucci G,Buccigrossi V,de Freitas MB,Guarino A,Giannattasio A

更新日期：2017-01-01 00:00:00

abstract：:Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections. Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosys...

journal_title：Journal of immunology research

authors： Bertran T,Brachet P,Vareille-Delarbre M,Falenta J,Dosgilbert A,Vasson MP,Forestier C,Tridon A,Evrard B

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. METHODS:We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. RESULTS:After four rounds...

journal_title：Journal of immunology research

authors： Ruan GP,Yao X,Yang SJ,Wang JX,Shu F,Li ZA,Liu JF,Pang RQ,Pan XH

更新日期：2014-01-01 00:00:00

abstract：:Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...

journal_title：Journal of immunology research

authors： Liao H,Li Y,Zhang X,Zhao X,Zheng D,Shen D,Li R

更新日期：2020-08-27 00:00:00

abstract：Objective:This study aimed to investigate the correlation of CD4+/PD-1+ or CD4+/PD-1- tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods:A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed ce...

journal_title：Journal of immunology research

authors： Zhao YJ,Zhang J,Shi F,Hu ZP,Wu JP,Wu GJ,Wang RB,Zhou Q,Chang H,Li YN,Song QK

更新日期：2018-07-04 00:00:00

abstract：Background and Objectives:Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic ...

journal_title：Journal of immunology research

authors： Wang M,Lang G,Chen Y,Hu C,Guo Y,Tao R,Dong X,Zhu B

更新日期：2019-12-01 00:00:00

abstract：:Reduning injection is a traditional Chinese medicine injection which has multiple functions such as clearing heat, dispelling wind, and detoxification. Although Reduning injection was widely utilized, reports of its allergenicity emerged one after another. However, there is little research on its allergenic substances...

journal_title：Journal of immunology research

authors： Wang F,Li CY,Zheng YF,Li HY,Xiao W,Peng GP

更新日期：2016-01-01 00:00:00

abstract：:Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear th...

journal_title：Journal of immunology research

authors： Cronkite DA,Strutt TM

更新日期：2018-06-11 00:00:00

abstract：:Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet's disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD sus...

journal_title：Journal of immunology research

authors： Li XF,Huang ZZ,Hu YY,Niu YM,Cai JW

更新日期：2020-06-19 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 ...

journal_title：Journal of immunology research

authors： Mi L,Zhu S,Cai J,Xu S,Xue Z,Lu H

更新日期：2020-10-31 00:00:00

abstract：:Toll/IL-1R-domain-containing adaptor-inducing IFN-β (TRIF) is an important adaptor for TLR3- and TLR4-mediated inflammatory signaling pathways. Recent studies have shown that TRIF plays a key role in vessel inflammation and atherosclerosis; however, the precise mechanisms are unclear. We investigated the mechanisms of...

journal_title：Journal of immunology research

authors： Wu Y,Ye J,Guo R,Liang X,Yang L

更新日期：2018-06-07 00:00:00

abstract：:Propionibacterium acnes (P. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. We previously demonstrated that heat-killed P. acnes or its soluble polysaccharide (PS), extracted from the...

journal_title：Journal of immunology research

authors： Squaiella-Baptistão CC,Teixeira D,Mussalem JS,Ishimura ME,Longo-Maugéri IM

更新日期：2015-01-01 00:00:00

abstract：:Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enh...

journal_title：Journal of immunology research

authors： Wu Z,Nakanishi H

更新日期：2015-01-01 00:00:00

abstract：Objective:Safflower has antioxidant and anti-inflammatory activities. The two forms of preparations for safflower which are widely used in China are injection and decoction. The first step of the process for preparing an injection involves extracting safflower with water, which actually yields a decoction. This study i...

journal_title：Journal of immunology research

authors： Liao H,Li Y,Zhai X,Zheng B,Banbury L,Zhao X,Li R

更新日期：2019-05-06 00:00:00

abstract：:Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. In 33 patients with pSS without clinical features of CNS d...

journal_title：Journal of immunology research

authors： Dziadkowiak E,Sebastian A,Wieczorek M,Kusińska E,Waliszewska-Prosół M,Wiland P,Ejma M

更新日期：2018-04-05 00:00:00

abstract：:Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...

journal_title：Journal of immunology research

authors： Wan W,Cao L,Khanabdali R,Kalionis B,Tai X,Xia S

更新日期：2016-01-01 00:00:00

abstract：:We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; betwee...

journal_title：Journal of immunology research

authors： Li J,Leng X,Li Z,Ye Z,Li C,Li X,Zhu P,Wang Z,Zheng Y,Li X,Zhang M,Tian XP,Li M,Zhao J,Zhang FC,Zhao Y,Zeng X

更新日期：2014-01-01 00:00:00

abstract：:The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and V-domain Ig suppressor of T cell activation (VISTA), as well as the significance thereof, in clear cell carcinoma (CCC) of the cervix (a rare histological subt...

journal_title：Journal of immunology research

authors： Zong L,Zhang Q,Zhou Y,Kong Y,Yu S,Chen J,Zhang Y,Xiang Y

更新日期：2020-04-03 00:00:00

abstract：Background:Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective:To investigate the...

journal_title：Journal of immunology research

authors： Karakus S,Baer AN,Akpek EK

更新日期：2019-01-13 00:00:00

abstract：:Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown....

journal_title：Journal of immunology research

authors： Frempah B,Luckett-Chastain LR,Gallucci RM

更新日期：2019-10-29 00:00:00

abstract：:Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated ...

journal_title：Journal of immunology research

authors： Fan WL,Shiao MS,Hui RC,Su SC,Wang CW,Chang YC,Chung WH

更新日期：2017-01-01 00:00:00

abstract：:Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson sy...

journal_title：Journal of immunology research

authors： Ng CY,Chen CB,Wu MY,Wu J,Yang CH,Hui RC,Chang YC,Lu CW

更新日期：2018-01-17 00:00:00

abstract：:Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and...

journal_title：Journal of immunology research

authors： Maranduba CM,De Castro SB,de Souza GT,Rossato C,da Guia FC,Valente MA,Rettore JV,Maranduba CP,de Souza CM,do Carmo AM,Macedo GC,Silva Fde S

更新日期：2015-01-01 00:00:00

abstract：:Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together. Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-larg...

journal_title：Journal of immunology research

authors： László I,Trásy D,Molnár Z,Fazakas J

更新日期：2015-01-01 00:00:00

abstract：:Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the p...

journal_title：Journal of immunology research

authors： Arreola R,Alvarez-Herrera S,Pérez-Sánchez G,Becerril-Villanueva E,Cruz-Fuentes C,Flores-Gutierrez EO,Garcés-Alvarez ME,de la Cruz-Aguilera DL,Medina-Rivero E,Hurtado-Alvarado G,Quintero-Fabián S,Pavón L

更新日期：2016-01-01 00:00:00

abstract：:We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There ...

journal_title：Journal of immunology research

authors： Gonzalez-Lopez L,Rocha-Muñoz AD,Ponce-Guarneros M,Flores-Chavez A,Salazar-Paramo M,Nava A,Cardona-Muñoz EG,Fajardo-Robledo NS,Zavaleta-Muñiz SA,Garcia-Cobian T,Gamez-Nava JI

更新日期：2014-01-01 00:00:00

abstract：:In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...

journal_title：Journal of immunology research

authors： Trabanelli S,La Manna F,Romano M,Salvestrini V,Cavo M,Ciciarello M,Lemoli RM,Curti A

更新日期：2015-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...

journal_title：Journal of immunology research

authors： Ambatipudi S,Sharp GC,Clarke SLN,Plant D,Tobias JH,Evans DM,Barton A,Relton CL

更新日期：2018-08-14 00:00:00