Abstract:
:Mast cells are unique tissue-resident immune cells that secrete a diverse array of biologically active compounds that can stimulate, modulate, or suppress the immune response. Although mounting evidence supports that mast cells are consistently infiltrating tumors, their role as either a driving or an opposite force for cancer progression is still controversial. Particularly, in breast cancer, their function is still under discussion. While some studies have shown a protective role, recent evidence indicates that mast cells enhance blood and lymphatic vessel formation. Interestingly, one of the most important components of the mast cell cargo, the serine protease tryptase, is a potent angiogenic factor, and elevated serum tryptase levels correlate with bad prognosis in breast cancer patients. Likewise, histamine is known to induce tumor cell proliferation and tumor growth. In agreement, mast cell depletion reduces the size of mammary tumors and metastasis in murine models that spontaneously develop breast cancer. In this review, we will discuss the evidence supporting protumoral and antitumoral roles of mast cells, emphasizing recent findings placing mast cells as important drivers of tumor progression, as well as the potential use of these cells or their mediators as therapeutic targets.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Aponte-López A,Fuentes-Pananá EM,Cortes-Muñoz D,Muñoz-Cruz Sdoi
10.1155/2018/2584243subject
Has Abstractpub_date
2018-02-05 00:00:00pages
2584243eissn
2314-8861issn
2314-7156journal_volume
2018pub_type
杂志文章,评审abstract::It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression. Runx1, a regulator of FoxP3, controls the expression of adenosine deaminase (ADA)...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/989434
更新日期:2014-01-01 00:00:00
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/156380
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-04-16 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2014/734068
更新日期:2014-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
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更新日期:2018-03-25 00:00:00
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更新日期:2020-04-23 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/9084759
更新日期:2018-11-12 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
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更新日期:2019-10-07 00:00:00
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journal_title:Journal of immunology research
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更新日期:2020-05-28 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3651743
更新日期:2018-06-14 00:00:00
abstract::Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/3109135
更新日期:2016-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/4097642
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journal_title:Journal of immunology research
pub_type: 杂志文章
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journal_title:Journal of immunology research
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
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更新日期:2020-08-04 00:00:00
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pub_type: 杂志文章
doi:10.1155/2019/7935451
更新日期:2019-01-13 00:00:00
abstract::Macrophages, a kind of innate immune cells, derive from monocytes in circulation and play a crucial role in the innate and adaptive immunity. Under the stimulation of the signals from local microenvironment, macrophages generally tend to differentiate into two main functional phenotypes depending on their high plastic...
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更新日期:2020-07-28 00:00:00
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doi:10.1155/2020/8835393
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/4320195
更新日期:2018-02-11 00:00:00