Abstract:
:We have reported that folic acid, vitamin B12, and omega-3 fatty acids are interlinked in the one carbon cycle and have implications for fetal programming. Our earlier studies demonstrate that an imbalance in maternal micronutrients influence long chain polyunsaturated fatty acid metabolism and global methylation in rat placenta. We hypothesize that these changes are mediated through micronutrient dependent regulation of enzymes in one carbon cycle. Pregnant dams were assigned to six dietary groups with varying folic acid and vitamin B12 levels. Vitamin B12 deficient groups were supplemented with omega-3 fatty acid. Placental mRNA levels of enzymes, levels of phospholipids, and glutathione were determined. Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control. Omega-3 supplementation normalized CBS and MTHFR mRNA levels. Increased placental phosphatidylethanolamine (PE), phosphatidylcholine (PC), in the same group was also observed. Our data suggests that adverse effects of a maternal micronutrient imbalanced diet may be due to differential regulation of key genes encoding enzymes in one carbon cycle and omega-3 supplementation may ameliorate most of these changes.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Khot V,Kale A,Joshi A,Chavan-Gautam P,Joshi Sdoi
10.1155/2014/613078subject
Has Abstractpub_date
2014-01-01 00:00:00pages
613078eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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更新日期:2018-04-24 00:00:00
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doi:10.1155/2018/7459276
更新日期:2018-12-23 00:00:00
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pub_type: 杂志文章
doi:10.1155/2013/627907
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-02-07 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6701793
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/879263
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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doi:10.1155/2018/6038106
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pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1155/2018/1507979
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pub_type: 杂志文章
doi:10.1155/2014/941318
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00