Abstract:
Objectives:Percutaneous coronary intervention (PCI) is the mainstay treatment for coronary artery disease but complications such as in-stent restenosis and thrombosis remain problematic. Radiofrequency balloon angioplasty (RBA) can improve lumen dimension, fusing intimal tears, and artery dissection but is associated with higher restenosis rate. Methods:After establishing an atherosclerosis model based on endothelial abrasion and high cholesterol diet, forty-five rabbits were randomly divided into three groups: RBA (n=20), percutaneous transluminal angioplasty (PTA) (n=20), and control groups (n=5). The RBA and PTA groups were subdivided according to harvested time posttreatment, respectively (1 hour, 7 days, 14 days, and 28 days). Aorta segments were then isolated for hematoxylin and eosin staining, Masson trichrome staining, immunohistochemistry, and Western blot for TLR-4, NF-κB, MCP-1, and VCAM-1expression. Results:At 28 days, intimal area was significantly lower in the RBA group compared to the PTA and control groups, whilst luminal and medial area were comparable in the RBA and PTA group but higher and lower than the control group, respectively. Expression of TLR-4, NF-κB, MCP-1, and VCAM-1 showed no significant difference between RBA and PTA groups. Conclusions:RBA can depress the intimal hyperplasia and promote dilatation of the artery to greater extents than PTA at 28 days. However, this did not involve TLR-4 signaling pathway, which likely plays a negligible role in mediating restenosis. Reduction of intimal hyperplasia may be due to injury of ablation to the tunica media and inhibition of VSMC proliferation and migration.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chen Q,Wang M,Shao S,Liu H,Xia X,Tse G,Yuan M,Zhang Y,Liang X,Liu T,Li Gdoi
10.1155/2018/7459276subject
Has Abstractpub_date
2018-12-23 00:00:00pages
7459276eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章abstract::Chosen aspects of examinations of inorganic gunshot particles by means of scanning electron microscopy and energy dispersive X-ray spectrometry technique are presented. The research methodology of particles was worked out, which included a precise and repeatable procedure of the automatic detection and identification ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/428038
更新日期:2014-01-01 00:00:00
abstract::A standard protocol of dosimetric measurements is used by the organizations responsible for verifying that the doses delivered in radiation-therapy institutions are within authorized limits. This study evaluated a self-designed simple auditing phantom for use in verifying the dose of radiation therapy; the phantom des...
journal_title:BioMed research international
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abstract::Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of muscle mass and strength. The more rationale approach to delay the progression of sarcopenia is based on the combination of proper nutrition, possibly associated with the use of dietary supplements and a regular exercise program. ...
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/901941
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abstract::Natural enzyme mimics have attracted considerable attention due to leakage of enzymes and their easy denaturation during their storage and immobilization procedure. Here in this study, for the first time, a new iron oxide hydroxide, ferrihydrite - Fe1.44O0.32 (OH) 3.68 magnetic nanoparticles were synthesized by bacter...
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doi:10.1155/2019/7127869
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doi:10.1155/2015/986436
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更新日期:2016-01-01 00:00:00
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doi:10.1155/2014/695713
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2013/279197
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2013/192986
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-10-06 00:00:00
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pub_type: 杂志文章
doi:10.1155/2014/963032
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2019/2721578
更新日期:2019-04-24 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/867140
更新日期:2015-01-01 00:00:00
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doi:10.1155/2020/2064582
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pub_type: 已发布勘误
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doi:10.1155/2019/6832867
更新日期:2019-05-21 00:00:00
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更新日期:2013-01-01 00:00:00
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doi:10.1155/2014/520763
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3162649
更新日期:2016-01-01 00:00:00
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更新日期:2020-08-20 00:00:00