Abstract：
:N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations. Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Collectively, the effect of m6A on A-to-I suggests a previously underappreciated interplay between two distinct and abundant RNA modifications, highlighting a complex epitranscriptomic landscape.
journal_name
Mol Celljournal_title
Molecular cellauthors
Xiang JF,Yang Q,Liu CX,Wu M,Chen LL,Yang Ldoi
10.1016/j.molcel.2017.12.006subject
Has Abstractpub_date
2018-01-04 00:00:00pages
126-135.e6issue
1eissn
1097-2765issn
1097-4164pii
S1097-2765(17)30934-6journal_volume
69pub_type
杂志文章相关文献
MOLECULAR CELL文献大全abstract：:The TATA binding protein (TBP) is required for the expression of nearly all genes and is highly regulated both positively and negatively. Here, we use DNA microarrays to explore the genome-wide interplay of several TBP-interacting inhibitors in the yeast Saccharomyces cerevisiae. Our findings suggest the following: Th...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(02)00683-4
更新日期：2002-10-01 00:00:00
abstract：:Epigenetic silencing of transposons by Piwi-interacting RNAs (piRNAs) constitutes an RNA-based genome defense mechanism. Piwi endonuclease action amplifies the piRNA pool by generating new piRNAs from target transcripts by a poorly understood mechanism. Here, we identified mouse Fkbp6 as a factor in this biogenesis pa...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2012.07.019
更新日期：2012-09-28 00:00:00
abstract：:Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP sequencing in mouse embryonic stem cells (ESCs). Refined bioinformat...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2014.05.029
更新日期：2014-07-17 00:00:00
abstract：:Prenylated Rab proteins exist in the cytosol as soluble, high-affinity complexes with GDI that need to be disrupted for membrane attachment and targeting of Rab proteins. The Legionella pneumophila protein DrrA displaces GDI from Rab1:GDI complexes, incorporating Rab1 into Legionella-containing vacuoles and activating...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2009.11.014
更新日期：2009-12-25 00:00:00
abstract：:Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich's ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger gross chromosomal re...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2012.08.002
更新日期：2012-10-26 00:00:00
abstract：:Protein phase separation by low-complexity, intrinsically disordered domains generates membraneless organelles and links to neurodegeneration. Cellular prion protein (PrPC) contains such domains, causes spongiform degeneration, and is a receptor for Alzheimer's amyloid-β oligomers (Aβo). Here, we show that PrPC separa...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2018.10.009
更新日期：2018-11-01 00:00:00
abstract：:Faithful copying of the genome is essential for life. In eukaryotes, a single archaeo-eukaryotic primase (AEP), DNA primase, is required for the initiation and progression of DNA replication. Here we have identified additional eukaryotic AEP-like proteins with DNA-dependent primase and/or polymerase activity. Uniquely...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2013.10.034
更新日期：2013-11-21 00:00:00
abstract：:RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly understood. We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-CLIP, RIP-chip, and...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2011.06.007
更新日期：2011-08-05 00:00:00
abstract：:Comparisons of bacteriophage PRD1 and adenovirus protein structures and virion architectures have been instrumental in unraveling an evolutionary relationship and have led to a proposal of a phylogeny-based virus classification. The structure of the PRD1 spike protein P5 provides further insight into the evolution of ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2005.03.019
更新日期：2005-04-15 00:00:00
abstract：:In this issue, Randow and coworkers (von Muhlinen et al., 2012) report that LC3C plays an essential role in Salmonella clearance by interacting with the autophagic receptor NDP52, with consequent recruitment of all other ATG8 proteins to assist in the buildup of the autophagic membrane. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2012.10.020
更新日期：2012-11-09 00:00:00
abstract：:Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister chromatids. Several replication-fork-associated "cohesion establishment factors," including the multifunctional Ctf18-RFC complex, aid this process in as yet unknown ways. Here, we show that Ctf18-RFC...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2020.03.017
更新日期：2020-05-21 00:00:00
abstract：:Replication forks frequently break and must be repaired by recombination. A reconstituted reaction now allows the factors that coordinate conversion from a recombination intermediate back to a replication fork to be defined. The PriA protein plays a key role in this control. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s1097-2765(03)00110-2
更新日期：2003-03-01 00:00:00
abstract：:Although the structural core of the ribosome is conserved in all kingdoms of life, eukaryotic ribosomes are significantly larger and more complex than their bacterial counterparts. The extent to which these differences influence the molecular mechanism of translation remains elusive. Multiparticle cryo-electron micros...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2011.07.040
更新日期：2011-10-21 00:00:00
abstract：:RNA polymerases (RNAPs) are core components of the cellular transcriptional machinery. Progress with functional studies of eukaryotic RNAPs has been delayed by the fact that it has not yet been possible to assemble active enzymes from individual subunits. Archaeal RNAPs are directly comparable to eukaryotic RNAPII in ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(02)00629-9
更新日期：2002-09-01 00:00:00
abstract：:The Rictor/mTOR complex (also known as mTORC2) plays a critical role in cellular homeostasis by phosphorylating AGC kinases such as Akt and SGK at their hydrophobic motifs to activate downstream signaling. However, the regulation of mTORC2 and whether it has additional function(s) remain largely unknown. Here, we repo...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2010.08.016
更新日期：2010-09-10 00:00:00
abstract：:Elucidating the individual and collaborative functions of genome maintenance factors is critical for understanding how genome duplication is achieved. Here, we investigate a conserved scaffold in budding yeast, Rtt107, and its three partners: a SUMO E3 complex, a ubiquitin E3 complex, and Slx4. Biochemical and genetic...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2015.08.023
更新日期：2015-10-15 00:00:00
abstract：:In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2010.06.015
更新日期：2010-06-25 00:00:00
abstract：:Integration of the mycobacteriophage Bxb1 genome into its host chromosome is catalyzed by a serine-integrase, a member of the transposon-resolvase family of site-specific recombinases. These enzymes use a concerted mechanism of strand exchange involving double-stranded cleavages with two-base extensions, and covalent ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(03)00444-1
更新日期：2003-11-01 00:00:00
abstract：:In a recent issue of Molecular Cell, Jia et al. (2008) demonstrate that time-controlled repression of interferon-induced transcripts depends upon the interaction between an RNA structure in these transcripts and protein domains harbored by a mammalian aminoacyl-tRNA synthetase. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2008.03.006
更新日期：2008-04-11 00:00:00
abstract：:Multisubunit protein complexes pose a challenge to the coordinated regulation of individual components. We show how the yeast transactivating factor Met4 functions as a component of the SCF(Met30) ubiquitin ligase to synchronize its own activity with cofactor assembly. Cells maintain Met4 in a dormant state by a regul...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2010.11.018
更新日期：2010-12-22 00:00:00
abstract：:In this issue, He et al. (2015) show how herpes virus usurps a cellular metabolic enzyme to induce RIG-I deamidation and RNA-independent activation, likely to better prevent further innate immune responses. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2015.03.021
更新日期：2015-04-02 00:00:00
abstract：:The Salmonellae PhoQ sensor kinase senses the mammalian phagosome environment to activate a transcriptional program essential for virulence. The PhoQ periplasmic domain binds divalent cations, forming bridges with inner membrane phospholipids to maintain PhoQ repression. PhoQ also binds and is activated by cationic an...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2007.03.008
更新日期：2007-04-27 00:00:00
abstract：:Heterotrimeric G proteins communicate signals from activated G protein-coupled receptors to downstream effector proteins. In the phototransduction pathway responsible for vertebrate vision, the G protein-effector complex is composed of the GTP-bound transducin α subunit (GαT·GTP) and the cyclic GMP (cGMP) phosphodiest...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2020.09.013
更新日期：2020-10-15 00:00:00
abstract：:Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycogen synthesis in neurons must be tightly controlled due to neuronal sensitivity to perturbations in glycogen metabolism. Lafora disease (LD) is a fatal, congenital, neurodegenerative epilepsy. Mutations in the gene encod...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2014.11.020
更新日期：2015-01-22 00:00:00
abstract：:In bacterial and archaeal CRISPR immune pathways, DNA sequences from invading bacteriophage or plasmids are integrated into CRISPR loci within the host genome, conferring immunity against subsequent infections. The ribonucleoprotein complex Cascade utilizes RNAs generated from these loci to target complementary "nonse...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2012.03.020
更新日期：2012-06-08 00:00:00
abstract：:The splitting of chromosomes in anaphase and their delivery into the daughter cells needs to be accurately executed to maintain genome stability. Chromosome splitting requires the degradation of securin, whereas the distribution of the chromosomes into the daughter cells requires the degradation of cyclin B. We show t...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2015.09.022
更新日期：2015-11-05 00:00:00
abstract：:As solid tumors expand, oxygen and nutrients become limiting owing to inadequate vascularization and diffusion. How malignant cells cope with this potentially lethal metabolic stress remains poorly understood. We found that glucose shortage associated with malignant progression triggers apoptosis through the endoplasm...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2013.01.009
更新日期：2013-03-28 00:00:00
abstract：:PRDM9 determines the localization of meiotic recombination hotspots, which are associated with histone H3 methylation. It is not known whether PRDM9's methyltransferase activity is required or how some PRDM9 alleles can dominate the distribution of hotspots over other alleles. Diagouraga, Clément, and colleagues (2018...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2018.02.021
更新日期：2018-03-01 00:00:00
abstract：:Signal-induced alternative splicing of the CD45 gene in human T cells is essential for proper immune function. Skipping of the CD45 variable exons is controlled, in large part, by the recruitment of PSF to the pre-mRNA substrate upon T cell activation; however, the signaling cascade leading to exon exclusion has remai...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2010.09.013
更新日期：2010-10-08 00:00:00
abstract：:The transcriptional coactivators CBP and p300 are critical regulators of metazoan gene expression. They associate with many different DNA-bound transcription factors through small, conserved domains. We have identified a compactly folded 46 residue domain in CBP and p300, the IRF-3 binding domain (IBiD), and we have d...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(01)00333-1
更新日期：2001-09-01 00:00:00
