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A role for SIRT1 in the hypoxic response.

Abstract：

:In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Leiser SF,Kaeberlein M

doi

10.1016/j.molcel.2010.06.015

subject

Has Abstract

pub_date

2010-06-25 00:00:00

pages

779-80

issue

6

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(10)00456-9

journal_volume

38

pub_type

评论,杂志文章

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