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Mind the Gapmer: Implications of Co-transcriptional Cleavage by Antisense Oligonucleotides.

Abstract：

:While gapmers efficiently knock down as well as terminate transcription of nascent lncRNAs and mRNAs, Lee and Mendell (2020) and Lai et al. (2020) also demonstrate that Pol II termination is not observed with gapmers targeting the 3' terminal portions of the transcript.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Maranon DG,Wilusz J

doi

10.1016/j.molcel.2020.02.010

subject

Has Abstract

pub_date

2020-03-05 00:00:00

pages

932-933

issue

5

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(20)30080-0

journal_volume

77

pub_type

评论,杂志文章

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