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Emerging Principles of Gene Expression Programs and Their Regulation.

Abstract：

:Many mechanisms contribute to regulation of gene expression to ensure coordinated cellular behaviors and fate decisions. Transcriptional responses to external signals can consist of many hundreds of genes that can be parsed into different categories based on kinetics of induction, cell-type and signal specificity, and duration of the response. Here we discuss the structure of transcription programs and suggest a basic framework to categorize gene expression programs based on characteristics related to their control mechanisms. We also discuss possible evolutionary implications of this framework.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Pope SD,Medzhitov R

doi

10.1016/j.molcel.2018.07.017

subject

Has Abstract

pub_date

2018-08-02 00:00:00

pages

389-397

issue

3

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(18)30586-0

journal_volume

71

pub_type

杂志文章,评审

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