Abstract:
:We show that the IRF-2 oncoprotein represses virus-induced IFN-beta gene transcription via a novel mechanism. Virus infection induces recruitment of IRF-2 to some of the endogenous IFN-beta enhancers as part of the enhanceosome. Enhanceosomes bearing IRF-2 cannot activate transcription, due to the presence of a domain in IRF-2 that prevents enhanceosome-dependent recruitment of the CBP-Pol II holoenzyme complex. As a consequence, IRF-2 incorporation into enhanceosomes restricts the number of IFN-beta promoters directing transcription. Remarkably, deletion of the IRF-2 gene increases IFN-beta expression by expanding the number of cells capable of inducing IFN-beta gene transcription in response to virus infection.
journal_name
Mol Celljournal_title
Molecular cellauthors
Senger K,Merika M,Agalioti T,Yie J,Escalante CR,Chen G,Aggarwal AK,Thanos Ddoi
10.1016/s1097-2765(05)00081-xsubject
Has Abstractpub_date
2000-10-01 00:00:00pages
931-7issue
4eissn
1097-2765issn
1097-4164pii
S1097-2765(05)00081-Xjournal_volume
6pub_type
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