Abstract：
:Formation and maintenance of specialized plasma membrane domains are crucial for many biological processes, such as cell polarization and signaling. During isotropic bud growth, the yeast cell periphery is divided into two domains: the bud surface, an active site of exocytosis and growth, and the relatively quiescent surface of the mother cell. We found that cells lacking septins at the bud neck failed to maintain the exocytosis and morphogenesis factors Spa2, Sec3, Sec5, and Myo2 in the bud during isotropic growth. Furthermore, we found that septins were required for proper regulation of actin patch stability; septin-defective cells permitted to enter isotropic growth lost actin and growth polarity. We propose that septins maintain cell polarity by specifying a boundary between cortical domains.
journal_name
Mol Celljournal_title
Molecular cellauthors
Barral Y,Mermall V,Mooseker MS,Snyder Mdoi
10.1016/s1097-2765(00)80324-xsubject
Has Abstractpub_date
2000-05-01 00:00:00pages
841-51issue
5eissn
1097-2765issn
1097-4164pii
S1097-2765(00)80324-Xjournal_volume
5pub_type
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