Distinct signals generate repeating striped pattern in the embryonic parasegment.

Abstract:

:How repeating striped patterns arise across cellular fields is unclear. To address this we examined the repeating pattern of Stripe (Sr) expression across the parasegment (PS) in Drosophila. This pattern is generated in two steps. First, the ligands Hedgehog (Hh) and Wingless (Wg) subdivide the PS into smaller territories. Second, the ligands Hh, Spitz (Spi), and Wg each emanate from a specific territory and induce Sr expression in an adjacent territory. We also show that the width of Sr expression is determined by signaling strength. Finally, an enhancer trap in the sr gene detects the response to Spi and Wg, but not to Hh, implying the existence of separable control elements in the sr gene. Thus, a distinct inductive event is used to initiate each element of the repeating striped pattern.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Hatini V,DiNardo S

doi

10.1016/s1097-2765(01)00163-0

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

151-60

issue

1

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(01)00163-0

journal_volume

7

pub_type

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