Abstract:
:How repeating striped patterns arise across cellular fields is unclear. To address this we examined the repeating pattern of Stripe (Sr) expression across the parasegment (PS) in Drosophila. This pattern is generated in two steps. First, the ligands Hedgehog (Hh) and Wingless (Wg) subdivide the PS into smaller territories. Second, the ligands Hh, Spitz (Spi), and Wg each emanate from a specific territory and induce Sr expression in an adjacent territory. We also show that the width of Sr expression is determined by signaling strength. Finally, an enhancer trap in the sr gene detects the response to Spi and Wg, but not to Hh, implying the existence of separable control elements in the sr gene. Thus, a distinct inductive event is used to initiate each element of the repeating striped pattern.
journal_name
Mol Celljournal_title
Molecular cellauthors
Hatini V,DiNardo Sdoi
10.1016/s1097-2765(01)00163-0subject
Has Abstractpub_date
2001-01-01 00:00:00pages
151-60issue
1eissn
1097-2765issn
1097-4164pii
S1097-2765(01)00163-0journal_volume
7pub_type
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