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Ras enhances Myc protein stability.

Abstract：

:Various experiments have demonstrated a collaborative action of Myc and Ras, both in normal cell growth control as well as during oncogenesis. We now show that Ras enhances the accumulation of Myc activity by stabilizing the Myc protein. Whereas Myc has a very short half-life when produced in the absence of mitogenic signals, due to degradation by the 26S proteasome, the half-life of Myc increases markedly in growth-stimulated cells. This stabilization is dependent on the Ras/Raf/MAPK pathway and is not augmented by proteasome inhibition, suggesting that Ras inhibits the proteasome-dependent degradation of Myc. We propose that one aspect of Myc-Ras collaboration is an ability of Ras to enhance the accumulation of transcriptionally active Myc protein.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Sears R,Leone G,DeGregori J,Nevins JR

doi

10.1016/s1097-2765(00)80308-1

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

169-79

issue

2

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(00)80308-1

journal_volume

3

pub_type

杂志文章

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