Abstract:
:Cardozo Gizzi et al. (2019) develop a new sequential imaging methodology (Hi-M) for observing chromosome structure in the Drosophila blastoderm and find that topological domains in single nuclei change in response to transcriptional activation.
journal_name
Mol Celljournal_title
Molecular cellauthors
Larson DRdoi
10.1016/j.molcel.2019.03.017subject
Has Abstractpub_date
2019-04-04 00:00:00pages
3-4issue
1eissn
1097-2765issn
1097-4164pii
S1097-2765(19)30221-7journal_volume
74pub_type
评论,杂志文章相关文献
MOLECULAR CELL文献大全abstract::Using improved techniques, Baptista et al. (2017) and Warfield et al. (2017) revisit fundamental questions about SAGA and TFIID function in yeast. They conclude that each complex independently contributes to the expression of all genes transcribed by RNA polymerase II. ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2017.09.028
更新日期:2017-10-05 00:00:00
abstract::Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycogen synthesis in neurons must be tightly controlled due to neuronal sensitivity to perturbations in glycogen metabolism. Lafora disease (LD) is a fatal, congenital, neurodegenerative epilepsy. Mutations in the gene encod...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2014.11.020
更新日期:2015-01-22 00:00:00
abstract::Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.04.024
更新日期:2016-05-05 00:00:00
abstract::Transcriptional and posttranslational signals are known mechanisms that promote efficient responses to DNA damage. We have identified Saccharomyces cerevisiae tRNA methyltransferase 9 (Trm9) as an enzyme that prevents cell death via translational enhancement of DNA damage response proteins. Trm9 methylates the uridine...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.09.021
更新日期:2007-12-14 00:00:00
abstract::Cells constantly adjust their metabolism in response to environmental conditions, yet major mechanisms underlying survival remain poorly understood. We discover a posttranscriptional mechanism that integrates starvation response with GTP homeostasis to allow survival, enacted by the nucleotide (p)ppGpp, a key player i...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.08.009
更新日期:2012-10-26 00:00:00
abstract::Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are largely unknown. We have carried out whole-genome bisulfite sequencing (BS-Seq) and RNA-Seq across key stages from E6.5 epiblast to E16.5 PGCs. Global...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.11.001
更新日期:2012-12-28 00:00:00
abstract::Inappropriate activation of oncogenic kinases at intracellular locations is frequently observed in human cancers, but its effects on global signaling are incompletely understood. Here, we show that the oncogenic mutant of Flt3 (Flt3-ITD), when localized at the endoplasmic reticulum (ER), aberrantly activates STAT5 and...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.09.019
更新日期:2009-10-23 00:00:00
abstract::Analysis of nuclear hormone receptor function in cells derived from xeroderma pigmentosum patients reveals novel links between DNA repair and transcription and points to novel mechanisms of regulating transcriptional regulators. ...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/s1097-2765(02)00511-7
更新日期:2002-04-01 00:00:00
abstract::Metazoan histone mRNAs are unique: their pre-mRNAs contain no introns, and the mRNAs are not polyadenylated, ending instead in a conserved stem-loop structure. In Drosophila, canonical poly(A) signals are located downstream of the normal cleavage site of each histone gene and are utilized when histone 3' end formation...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.04.024
更新日期:2009-05-15 00:00:00
abstract::Proliferating metazoan cells respond to damage that has the potential to cause genomic instability by restricting the cell division cycle or by initiating apoptosis. The molecular mechanisms determining the balance between these responses are not well understood. Here, we show that the apoptotic initiator protease cas...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.03.019
更新日期:2007-04-27 00:00:00
abstract::Cse4 is a variant of histone H3 that is incorporated into a single nucleosome at each centromere in budding yeast. We have discovered an E3 ubiquitin ligase, called Psh1, which controls the cellular level of Cse4 via ubiquitylation and proteolysis. The activity of Psh1 is dependent on both its RING and zinc finger dom...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.10.014
更新日期:2010-11-12 00:00:00
abstract::The orphan nuclear receptors SF-1 and LRH-1 are constitutively active, but it remains uncertain whether their activation is hormone dependent. We report the crystal structure of the LRH-1 ligand binding domain to 2.4 A resolution and find the receptor to be a monomer that adopts an active conformation with a large but...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00236-3
更新日期:2003-06-01 00:00:00
abstract::In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interactions between RNA molec...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/s1097-2765(02)00429-x
更新日期:2002-01-01 00:00:00
abstract::miRNAs are largely known to base pair with the 3'UTR of target mRNAs, downregulating their stability and translation. mRNA of betaTrCP1 ubiquitin ligase is very unstable, but unlike the majority of mRNAs where 3'UTR determines the rate of mRNA turnover, betaTrCP1 mRNA contains cis-acting destabilizing elements within ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.06.007
更新日期:2009-07-31 00:00:00
abstract::Cell pattern in the ventral neural tube is organized by Sonic hedgehog (Shh) secreted by floor plate cells. To assay the range of direct Shh action, we developed a general method for blocking transduction of Hedgehog (Hh) signals through ectopic expression of a deleted form of the Hh receptor Patched (Ptc), termed Ptc...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(01)00271-4
更新日期:2001-06-01 00:00:00
abstract::A kinase-anchoring proteins (AKAPs) target PKA to specific microdomains by using an amphipathic helix that docks to N-terminal dimerization and docking (D/D) domains of PKA regulatory (R) subunits. To understand specificity, we solved the crystal structure of the helical motif from D-AKAP2, a dual-specific AKAP, bound...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2006.09.015
更新日期:2006-11-03 00:00:00
abstract::When inappropriate DNA structures arise, they are sensed by DNA structure-dependent checkpoint pathways and subsequently repaired. Recruitment of checkpoint proteins to such structures precedes recruitment of proteins involved in DNA metabolism. Thus, checkpoints can regulate DNA metabolism. We show that fission yeast...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.10.026
更新日期:2010-11-24 00:00:00
abstract::The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease activity for processing its own guide RNAs and RNA-guided DNase activity for target DNA cleavage. To elucidate the molecular basis of both activities, we determined cr...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2017.03.016
更新日期:2017-04-20 00:00:00
abstract::Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double helices. SMC subunits comprise an ABC ATPase "head" and a "hinge" dimerization domain connected by a 49 nm coiled-coil "arm." The heads undergo ATP-dependent engageme...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2017.06.010
更新日期:2017-07-20 00:00:00
abstract::The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic Ras. These pathways negatively regulate each other, but the mechanism involved is incompletely understood. We now identify MEK1 as an essential regulator of lipid/protein phosphatase PTEN, through which it controls phosphatidylinositol-3-phosph...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.01.037
更新日期:2013-04-11 00:00:00
abstract::Takahashi et al. (2018) report that the peptide CLE25 together with the BAM1, BAM3 LRR receptor-like kinases are involved in root-to-shoot communication during dehydration stress in Arabidopsis. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2018.06.011
更新日期:2018-06-21 00:00:00
abstract::Autophagic turnover of intracellular constituents is critical for cellular housekeeping, nutrient recycling, and various aspects of growth and development in eukaryotes. Here we show that autophagy impacts the other major degradative route involving the ubiquitin-proteasome system by eliminating 26S proteasomes, a pro...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.04.023
更新日期:2015-06-18 00:00:00
abstract::XPG is a structure-specific endonuclease required for nucleotide excision repair, and incision-defective XPG mutations cause the skin cancer-prone syndrome xeroderma pigmentosum. Truncating mutations instead cause the neurodevelopmental progeroid disorder Cockayne syndrome, but little is known about how XPG loss resul...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.12.026
更新日期:2016-02-18 00:00:00
abstract::The Holliday junction is a central intermediate in homologous recombination. It consists of a four-way structure that can be resolved by cleavage to give either the crossover or noncrossover products observed. We show here that the formation of these products is controlled by the E. coli resolvasome (RuvABC) in such w...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(05)00095-x
更新日期:2000-10-01 00:00:00
abstract::We report an interaction between poxA, encoding a paralog of lysyl tRNA-synthetase, and the closely linked yjeK gene, encoding a putative 2,3-beta-lysine aminomutase, that is critical for virulence and stress resistance in Salmonella enterica. Salmonella poxA and yjeK mutants share extensive phenotypic pleiotropy, inc...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.06.021
更新日期:2010-07-30 00:00:00
abstract::YAP/TEAD are nuclear effectors of the Hippo pathway, regulating organ size and tumorigenesis largely through promoter-associated function. However, their function as enhancer regulators remains poorly understood. Through an in vivo proximity-dependent labeling (BioID) technique, we identified YAP1 and TEAD4 protein as...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2019.06.010
更新日期:2019-08-22 00:00:00
abstract::Posttranslational modification with small ubiquitin-related modifier (SUMO) has emerged as a central regulatory mechanism of protein function. However, little is known about the regulation of sumoylation itself. It has been reported that it is increased after exposure to various stresses including strong oxidative str...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2005.12.019
更新日期:2006-02-03 00:00:00
abstract::Cas9 is a prokaryotic RNA-guided DNA endonuclease that binds substrates tightly in vitro but turns over rapidly when used to manipulate genomes in eukaryotic cells. Little is known about the factors responsible for dislodging Cas9 or how they influence genome engineering. Unbiased detection through proximity labeling ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2020.06.014
更新日期:2020-07-16 00:00:00
abstract::Wu et al. (2019) establish that the active zone proteins RIM and RIM-BP undergo liquid-liquid phase separation to tether Ca2+ channels. This important finding sets a new framework to study assembly and function of the presynaptic nerve terminal. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2019.02.020
更新日期:2019-03-07 00:00:00
abstract::In a recent issue of Molecular Cell, Büttner et al. (2007) described dual roles for the conserved mitochondrial protein endonuclease G in budding yeast apoptosis and proliferation that illuminate some of the contradictory and confusing findings regarding this protein in mammalian cells. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.molcel.2007.01.030
更新日期:2007-02-09 00:00:00