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Principles and properties of eukaryotic mRNPs.

Abstract：

:The proper processing, export, localization, translation, and degradation of mRNAs are necessary for regulation of gene expression. These processes are controlled by mRNA-specific regulatory proteins, noncoding RNAs, and core machineries common to most mRNAs. These factors bind the mRNA in large complexes known as messenger ribonucleoprotein particles (mRNPs). Herein, we review the components of mRNPs, how they assemble and rearrange, and how mRNP composition differentially affects mRNA biogenesis, function, and degradation. We also describe how properties of the mRNP "interactome" lead to emergent principles affecting the control of gene expression.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Mitchell SF,Parker R

doi

10.1016/j.molcel.2014.04.033

subject

Has Abstract

pub_date

2014-05-22 00:00:00

pages

547-58

issue

4

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(14)00394-3

journal_volume

54

pub_type

杂志文章,评审

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