Tbf1 or not Tbf1?

Abstract:

:In this issue of Molecular Cell, Hogues et al. (2008) demonstrate a wholesale shift in the key regulatory protein involved in ribosomal protein (RP) synthesis during the evolution of S. cerevisiae and, en passant, raise interesting questions about the relationship between RP genes and telomeres.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Bhattacharya A,Warner JR

doi

10.1016/j.molcel.2008.02.008

subject

Has Abstract

pub_date

2008-03-14 00:00:00

pages

537-8

issue

5

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(08)00126-3

journal_volume

29

pub_type

评论,杂志文章
  • The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex.

    abstract::Early endocytic membrane traffic is regulated by the small GTPase Rab5, which cycles between GTP- and GDP-bound states as well as between membrane and cytosol. The latter cycle depends on GDI, which functions as a Rab vehicle in the aqueous environment of the cytosol. Here, we report that formation of the GDI:Rab5 com...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(01)00189-7

    authors: Cavalli V,Vilbois F,Corti M,Marcote MJ,Tamura K,Karin M,Arkinstall S,Gruenberg J

    更新日期:2001-02-01 00:00:00

  • Chromatin remodeling in vivo: evidence for a nucleosome sliding mechanism.

    abstract::Members of the ISWI family of chromatin remodeling factors exhibit ATP-dependent nucleosome sliding, loading, and spacing activities in vitro. However, it is unclear which of these activities are utilized by ISWI complexes to remodel chromatin in vivo. We therefore sought to identify the mechanisms of chromatin remode...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(03)00436-2

    authors: Fazzio TG,Tsukiyama T

    更新日期:2003-11-01 00:00:00

  • SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation.

    abstract::The Wnt3a/β-catenin and Activin/SMAD2,3 signaling pathways synergize to induce endodermal differentiation of human embryonic stem cells; however, the underlying mechanism is not well understood. Using ChIP-seq and GRO-seq analyses, we show here that Wnt3a-induced β-catenin:LEF-1 enhancers recruit cohesin to direct enh...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2015.04.001

    authors: Estarás C,Benner C,Jones KA

    更新日期:2015-06-04 00:00:00

  • A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.

    abstract::X-linked mental retardation (XLMR) is an inherited disorder that mostly affects males and is caused by mutations in genes located on the X chromosome. Here, we show that the XLMR protein PHF8 and a C. elegans homolog F29B9.2 catalyze demethylation of di- and monomethylated lysine 9 of histone H3 (H3K9me2/me1). The PHD...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2010.03.002

    authors: Kleine-Kohlbrecher D,Christensen J,Vandamme J,Abarrategui I,Bak M,Tommerup N,Shi X,Gozani O,Rappsilber J,Salcini AE,Helin K

    更新日期:2010-04-23 00:00:00

  • Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance.

    abstract::Tet(O) belongs to a class of ribosomal protection proteins that mediate tetracycline resistance. It is a G protein that shows significant sequence similarity to elongation factor EF-G. Here we present a cryo-electron microscopic reconstruction, at 16 A resolution, of its complex with the E. coli 70S ribosome. Tet(O) w...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(01)00238-6

    authors: Spahn CM,Blaha G,Agrawal RK,Penczek P,Grassucci RA,Trieber CA,Connell SR,Taylor DE,Nierhaus KH,Frank J

    更新日期:2001-05-01 00:00:00

  • Frozen in Transcription: Cryo-EM Structures of Pol II Transcribing through a Nucleosome.

    abstract::In a recent publication in Science, Kujirai et al. (2018) use single-particle cryo-EM to resolve several Pol II-nucleosome interactions, shedding new light on transcription elongation in a native chromatin environment. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2018.11.027

    authors: Noe Gonzalez M,Conaway RC,Conaway JW

    更新日期:2018-12-06 00:00:00

  • Phosphatidic Acid Signals via the Hippo Pathway.

    abstract::In this issue of Molecular Cell, Han et al. (2018) show that phosphatidic acid inhibits the action of the LATS kinases, key mediators of Hippo pathway signaling, which leads to an increase in the nuclear activity of the transcriptional regulator YAP. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2018.10.004

    authors: Stampouloglou E,Varelas X

    更新日期:2018-10-18 00:00:00

  • Stress-induced map kinase Hog1 is part of transcription activation complexes.

    abstract::In response to hyperosmotic environments, most eukaryotic cells activate a specialized mitogen-activated protein (MAP) kinase pathway. In S. cerevisiae, the key protein kinase, Hog1, coordinates the transcriptional induction of a variety of genes devoted to osmoadaptation and general stress protection. Depending on th...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(01)00221-0

    authors: Alepuz PM,Jovanovic A,Reiser V,Ammerer G

    更新日期:2001-04-01 00:00:00

  • A transcriptional activator is part of an SCF ubiquitin ligase to control degradation of its cofactors.

    abstract::Multisubunit protein complexes pose a challenge to the coordinated regulation of individual components. We show how the yeast transactivating factor Met4 functions as a component of the SCF(Met30) ubiquitin ligase to synchronize its own activity with cofactor assembly. Cells maintain Met4 in a dormant state by a regul...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2010.11.018

    authors: Ouni I,Flick K,Kaiser P

    更新日期:2010-12-22 00:00:00

  • Modular RNA heats up.

    abstract::In this issue of Molecular Cell, Mariner et al. (2008) demonstrate that Alu RNA from a human SINE represses RNA polymerase II transcription during heat shock. This noncoding RNA is the first example of a "protein-like" transcription factor with a distinct modular architecture. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2008.02.001

    authors: Shamovsky I,Nudler E

    更新日期:2008-02-29 00:00:00

  • METTL3 Gains R/W Access to the Epitranscriptome.

    abstract::Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2016.04.024

    authors: Schumann U,Shafik A,Preiss T

    更新日期:2016-05-05 00:00:00

  • Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors.

    abstract::Allosteric communication between interacting molecules is fundamental to signal transduction and many other cellular processes. To better understand the relationship between nuclear receptor (NR) ligand positioning and the formation of the coactivator binding pocket, we investigated the determinants of ligand selectiv...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(04)00054-1

    authors: Nettles KW,Sun J,Radek JT,Sheng S,Rodriguez AL,Katzenellenbogen JA,Katzenellenbogen BS,Greene GL

    更新日期:2004-02-13 00:00:00

  • Y14 and hUpf3b form an NMD-activating complex.

    abstract::Messenger RNAs with premature translation termination codons (PTCs) are degraded by nonsense-mediated mRNA decay (NMD). In mammals, PTCs are discriminated from physiological stop codons by a process thought to involve the splicing-dependent deposition of an exon junction complex (EJC), EJC-mediated recruitment of Upf3...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(03)00142-4

    authors: Gehring NH,Neu-Yilik G,Schell T,Hentze MW,Kulozik AE

    更新日期:2003-04-01 00:00:00

  • The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal.

    abstract::Proteins are translocated across membranes through a channel that is formed by the prokaryotic SecY or eukaryotic Sec61 complex. The crystal structure of the SecY channel from M. jannaschii revealed a plug domain that appears to seal the channel in its closed state. However, the role of the plug remains unclear, parti...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2007.05.002

    authors: Li W,Schulman S,Boyd D,Erlandson K,Beckwith J,Rapoport TA

    更新日期:2007-05-25 00:00:00

  • The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.

    abstract::The fidelity of chromosome segregation depends on the spindle assembly checkpoint (SAC). In the presence of unattached kinetochores, anaphase is delayed when three SAC components (Mad2, Mad3/BubR1, and Bub3) inhibit Cdc20, the activating subunit of the anaphase-promoting complex (APC/C). We analyzed the role of Cdc20 ...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2012.07.031

    authors: Foster SA,Morgan DO

    更新日期:2012-09-28 00:00:00

  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.

    abstract::The bHLH factors HAND1 and HAND2 are required for heart, vascular, neuronal, limb, and extraembryonic development. Unlike most bHLH proteins, HAND factors exhibit promiscuous dimerization properties. We report that phosphorylation/dephosphorylation via PKA, PKC, and a specific heterotrimeric protein phosphatase 2A (PP...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(03)00425-8

    authors: Firulli BA,Howard MJ,McDaid JR,McIlreavey L,Dionne KM,Centonze VE,Cserjesi P,Virshup DM,Firulli AB

    更新日期:2003-11-01 00:00:00

  • Diabetes mutations delineate an atypical POU domain in HNF-1alpha.

    abstract::Mutations in Hnf-1alpha are the most common Mendelian cause of diabetes mellitus. To elucidate the molecular function of a mutational hotspot, we cocrystallized human HNF-1alpha 83-279 with a high-affinity promoter and solved the structure of the complex. Two identical protein molecules are bound to the promoter. Each...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(02)00704-9

    authors: Chi YI,Frantz JD,Oh BC,Hansen L,Dhe-Paganon S,Shoelson SE

    更新日期:2002-11-01 00:00:00

  • Interplay of TBP inhibitors in global transcriptional control.

    abstract::The TATA binding protein (TBP) is required for the expression of nearly all genes and is highly regulated both positively and negatively. Here, we use DNA microarrays to explore the genome-wide interplay of several TBP-interacting inhibitors in the yeast Saccharomyces cerevisiae. Our findings suggest the following: Th...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(02)00683-4

    authors: Chitikila C,Huisinga KL,Irvin JD,Basehoar AD,Pugh BF

    更新日期:2002-10-01 00:00:00

  • Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells.

    abstract::Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich's ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger gross chromosomal re...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2012.08.002

    authors: Zhang Y,Shishkin AA,Nishida Y,Marcinkowski-Desmond D,Saini N,Volkov KV,Mirkin SM,Lobachev KS

    更新日期:2012-10-26 00:00:00

  • Execution of the circadian negative feedback loop in Neurospora requires the ATP-dependent chromatin-remodeling enzyme CLOCKSWITCH.

    abstract::In the Neurospora circadian system, the transcription factors White Collar-1 (WC-1) and White Collar-2 (WC-2) activate expression of frq, whose gene product inhibits its own expression. The WC proteins are thought to form an obligate complex; however, chromatin immunoprecipitation (ChIP) indicates that WC-2 binds to t...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2007.01.010

    authors: Belden WJ,Loros JJ,Dunlap JC

    更新日期:2007-02-23 00:00:00

  • HuR and translation--the missing linc(RNA).

    abstract::In this issue, Yoon et al. (2012) reveal that HuR influences decay of a long noncoding RNA (lincRNA-p21) that in turn hybridizes to mRNA targets and represses their translation-an indirect, but elegant explanation for the impact of HuR on translation efficiency. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2012.08.005

    authors: Wilusz CJ,Wilusz J

    更新日期:2012-08-24 00:00:00

  • Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters.

    abstract::Polycomb repressive complex 2 (PRC2) places H3K27me3 at developmental genes and is causally implicated in keeping bivalent genes silent. It is unclear if that silence requires minimum H3K27me3 levels and how the mark transmits faithfully across mammalian somatic cell generations. Mouse intestinal cells lacking EZH2 me...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2020.01.017

    authors: Jadhav U,Manieri E,Nalapareddy K,Madha S,Chakrabarti S,Wucherpfennig K,Barefoot M,Shivdasani RA

    更新日期:2020-04-02 00:00:00

  • E1 on the move.

    abstract::E1 enzymes activate ubiquitin or related proteins and pass them to E2 enzymes. A recent structure and associated biochemical studies (Huang et al., 2005) show how an E1 binds its cognate E2 and indicates that large, conformational changes will be an integral component of the E1 reaction cycle. ...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.molcel.2005.02.004

    authors: VanDemark AP,Hill CP

    更新日期:2005-02-18 00:00:00

  • A role for TBP dimerization in preventing unregulated gene expression.

    abstract::The recruitment of the TATA box-binding protein (TBP) to promoters in vivo is often rate limiting in gene expression. We present evidence that TBP negatively autoregulates its accessibility to promoter DNA in yeast through dimerization. The crystal structure of TBP dimers was used to design point mutations in the dime...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(01)80004-6

    authors: Jackson-Fisher AJ,Chitikila C,Mitra M,Pugh BF

    更新日期:1999-06-01 00:00:00

  • The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160.

    abstract::In yeast Saccharomyces cerevisiae the G protein betagamma subunits (Ste4/Ste18) have long been known to transmit the signal required for mating. Here we demonstrate that GTPase-deficient mutants of Galpha (Gpa1) directly activate the mating response pathway. We also show that signaling by activated Gpa1 requires direc...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(03)00307-1

    authors: Guo M,Aston C,Burchett SA,Dyke C,Fields S,Rajarao SJ,Uetz P,Wang Y,Young K,Dohlman HG

    更新日期:2003-08-01 00:00:00

  • A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer.

    abstract::YAP/TEAD are nuclear effectors of the Hippo pathway, regulating organ size and tumorigenesis largely through promoter-associated function. However, their function as enhancer regulators remains poorly understood. Through an in vivo proximity-dependent labeling (BioID) technique, we identified YAP1 and TEAD4 protein as...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2019.06.010

    authors: Zhu C,Li L,Zhang Z,Bi M,Wang H,Su W,Hernandez K,Liu P,Chen J,Chen M,Huang TH,Chen L,Liu Z

    更新日期:2019-08-22 00:00:00

  • Trm9-catalyzed tRNA modifications link translation to the DNA damage response.

    abstract::Transcriptional and posttranslational signals are known mechanisms that promote efficient responses to DNA damage. We have identified Saccharomyces cerevisiae tRNA methyltransferase 9 (Trm9) as an enzyme that prevents cell death via translational enhancement of DNA damage response proteins. Trm9 methylates the uridine...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2007.09.021

    authors: Begley U,Dyavaiah M,Patil A,Rooney JP,DiRenzo D,Young CM,Conklin DS,Zitomer RS,Begley TJ

    更新日期:2007-12-14 00:00:00

  • Protein transport: two translocons are better than one.

    abstract::The translocon is the gateway to the endoplasmic reticulum (ER). In yeast this is the Sec61p complex. However, new evidence suggests that a second translocon containing the Sec61p homolog Ssh1p provides important flexibility to the ER translocation machinery. ...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(01)00339-2

    authors: Robb A,Brown JD

    更新日期:2001-09-01 00:00:00

  • Organelle-Specific Initiation of Autophagy.

    abstract::Autophagy constitutes a prominent mechanism through which eukaryotic cells preserve homeostasis in baseline conditions and in response to perturbations of the intracellular or extracellular microenvironment. Autophagic responses can be relatively non-selective or target a specific subcellular compartment. At least in ...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.molcel.2015.07.021

    authors: Sica V,Galluzzi L,Bravo-San Pedro JM,Izzo V,Maiuri MC,Kroemer G

    更新日期:2015-08-20 00:00:00

  • General and versatile autoinhibition of PLC isozymes.

    abstract::Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. Although PLCs play central roles in myriad signaling cascades, the molecular details of ...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2008.06.018

    authors: Hicks SN,Jezyk MR,Gershburg S,Seifert JP,Harden TK,Sondek J

    更新日期:2008-08-08 00:00:00