Abstract：
:Many genomic studies have revealed associations between the gut microbiota composition and host metabolism. These observations led to the idea that a causal relationship could exist between the microbiota and metabolic diseases, a concept supported by studies showing compositional changes in the microbial community in metabolic diseases and transmissibility of host phenotype via microbiota transfer. Accumulating data suggest that the microbiota may affect host metabolic phenotypes through the production of metabolites. These bioactive microbial metabolites, sensitive fingerprints of microbial function, can act as inter-kingdom signaling messengers via penetration into host blood circulation and tissues. These fingerprints may be used for diagnostic purposes, and increased understanding of strain specificity in producing microbial metabolites can identify bacterial strains or specific metabolites that can be used for therapeutic purposes. Here, we will review data supporting the causal role of the gut microbiota in metabolism and discuss mechanisms and potential clinical implications.
journal_name
Mol Celljournal_title
Molecular cellauthors
Koh A,Bäckhed Fdoi
10.1016/j.molcel.2020.03.005subject
Has Abstractpub_date
2020-05-21 00:00:00pages
584-596issue
4eissn
1097-2765issn
1097-4164pii
S1097-2765(20)30153-2journal_volume
78pub_type
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