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Growth factor withdrawal and apoptosis: the middle game.

Abstract：

:In this issue of Molecular Cell, detail molecular events that trigger apoptosis following growth factor withdrawal, linking irreversible mitochondrial permeabilization to activation of GSK-3 and subsequent phosphorylation, ubiquitinylation, and degradation of the antiapoptotic BCL-2 family member MCL-1.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Letai A

doi

10.1016/j.molcel.2006.03.005

subject

Has Abstract

pub_date

2006-03-17 00:00:00

pages

728-30

issue

6

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(06)00148-1

journal_volume

21

pub_type

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