Abstract:
:Cas4 nucleases are conserved factors in many CRISPR systems, yet their molecular role has remained enigmatic. In this issue of Molecular Cell, Shiimori et al. (2018) report that two Cas4 nucleases together determine the size, orientation, and PAM for foreign DNA snippets acquired by CRISPR loci as immunological memory.
journal_name
Mol Celljournal_title
Molecular cellauthors
Hou Z,Zhang Ydoi
10.1016/j.molcel.2018.05.028subject
Has Abstractpub_date
2018-06-07 00:00:00pages
757-758issue
5eissn
1097-2765issn
1097-4164pii
S1097-2765(18)30403-9journal_volume
70pub_type
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