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A splicing-independent function of SF2/ASF in microRNA processing.

Abstract：

:Both splicing factors and microRNAs are important regulatory molecules that play key roles in posttranscriptional gene regulation. By miRNA deep sequencing, we identified 40 miRNAs that are differentially expressed upon ectopic overexpression of the splicing factor SF2/ASF. Here we show that SF2/ASF and one of its upregulated microRNAs (miR-7) can form a negative feedback loop: SF2/ASF promotes miR-7 maturation, and mature miR-7 in turn targets the 3'UTR of SF2/ASF to repress its translation. Enhanced microRNA expression is mediated by direct interaction between SF2/ASF and the primary miR-7 transcript to facilitate Drosha cleavage and is independent of SF2/ASF's function in splicing. Other miRNAs, including miR-221 and miR-222, may also be regulated by SF2/ASF through a similar mechanism. These results underscore a function of SF2/ASF in pri-miRNA processing and highlight the potential coordination between splicing control and miRNA-mediated gene repression in gene regulatory networks.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Wu H,Sun S,Tu K,Gao Y,Xie B,Krainer AR,Zhu J

doi

10.1016/j.molcel.2010.02.021

subject

Has Abstract

pub_date

2010-04-09 00:00:00

pages

67-77

issue

1

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(10)00173-5

journal_volume

38

pub_type

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