Abstract:
:An exciting study in this issue reveals how binding of the microtubule associated protein TPX2 to the mitotic kinase Aurora A induces a conformational change. This moves the phosphorylated activation domain into a more compact position within the kinase core, providing a better substrate binding platform and hiding the activating phosphoryl group from attack by PP1.
journal_name
Mol Celljournal_title
Molecular cellauthors
Glover DMdoi
10.1016/s1097-2765(03)00405-2subject
Has Abstractpub_date
2003-10-01 00:00:00pages
797-9issue
4eissn
1097-2765issn
1097-4164pii
S1097-2765(03)00405-2journal_volume
12pub_type
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