Stay close to your sister.

Abstract:

:Yeast Sir2 protein regulates chromatin structure and suppresses recombination at the multiple tandem rDNA array. In the current issue of Cell, Kobayashi and colleagues reinvestigate rDNA dynamics in sir2 strains and find that Sir2 is necessary to recruit cohesins to the array, which influences the nature of rDNA recombination events.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Reid RJ,Rothstein R

doi

10.1016/s1097-2765(04)00266-7

subject

Has Abstract

pub_date

2004-05-21 00:00:00

pages

418-20

issue

4

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(04)00266-7

journal_volume

14

pub_type

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    abstract::Nuclear import of proteins containing a classical nuclear localization signal (NLS) involves NLS recognition by importin alpha, which associates with importin beta via the IBB domain. Other proteins, including parathyroid hormone-related protein (PTHrP), are imported into the nucleus by direct interaction with importi...

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  • A Finer Print Than TADs: PRC1-Mediated Domains.

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  • Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over.

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  • SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.

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  • A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase.

    abstract::A kinase-anchoring proteins (AKAPs) target PKA to specific microdomains by using an amphipathic helix that docks to N-terminal dimerization and docking (D/D) domains of PKA regulatory (R) subunits. To understand specificity, we solved the crystal structure of the helical motif from D-AKAP2, a dual-specific AKAP, bound...

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  • Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin.

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  • Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.

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    doi:

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  • Promoter Distortion and Opening in the RNA Polymerase II Cleft.

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  • Features of a leader peptide coding region that regulate translation initiation for the anti-TRAP protein of B. subtilis.

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  • FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.

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  • The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160.

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  • Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC.

    abstract::Gene expression mediated by viral vectors is subject to cell-to-cell variability, which limits the accuracy of gene delivery. When coupled with single-cell measurements, however, such variability provides an efficient means to quantify signaling dynamics in mammalian cells. Here, we illustrate the utility of this appr...

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    authors: Arif A,Jia J,Willard B,Li X,Fox PL

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