The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160.

Abstract:

:In yeast Saccharomyces cerevisiae the G protein betagamma subunits (Ste4/Ste18) have long been known to transmit the signal required for mating. Here we demonstrate that GTPase-deficient mutants of Galpha (Gpa1) directly activate the mating response pathway. We also show that signaling by activated Gpa1 requires direct coupling to an RNA binding protein Scp160. These findings suggest an additional role for Gpa1 and reveal Scp160 as a component of the mating response pathway in yeast.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Guo M,Aston C,Burchett SA,Dyke C,Fields S,Rajarao SJ,Uetz P,Wang Y,Young K,Dohlman HG

doi

10.1016/s1097-2765(03)00307-1

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

517-24

issue

2

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(03)00307-1

journal_volume

12

pub_type

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