Abstract:
:In yeast Saccharomyces cerevisiae the G protein betagamma subunits (Ste4/Ste18) have long been known to transmit the signal required for mating. Here we demonstrate that GTPase-deficient mutants of Galpha (Gpa1) directly activate the mating response pathway. We also show that signaling by activated Gpa1 requires direct coupling to an RNA binding protein Scp160. These findings suggest an additional role for Gpa1 and reveal Scp160 as a component of the mating response pathway in yeast.
journal_name
Mol Celljournal_title
Molecular cellauthors
Guo M,Aston C,Burchett SA,Dyke C,Fields S,Rajarao SJ,Uetz P,Wang Y,Young K,Dohlman HGdoi
10.1016/s1097-2765(03)00307-1subject
Has Abstractpub_date
2003-08-01 00:00:00pages
517-24issue
2eissn
1097-2765issn
1097-4164pii
S1097-2765(03)00307-1journal_volume
12pub_type
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