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Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response.

Abstract：

:As sessile organisms, plants must adapt to variations in the environment. Environmental stress triggers various responses, including growth inhibition, mediated by the plant hormone abscisic acid (ABA). The mechanisms that integrate stress responses with growth are poorly understood. Here, we discovered that the Target of Rapamycin (TOR) kinase phosphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress response in unstressed plants. This phosphorylation disrupts PYL association with ABA and with PP2C phosphatase effectors, leading to inactivation of SnRK2 kinases. Under stress, ABA-activated SnRK2s phosphorylate Raptor, a component of the TOR complex, triggering TOR complex dissociation and inhibition. Thus, TOR signaling represses ABA signaling and stress responses in unstressed conditions, whereas ABA signaling represses TOR signaling and growth during times of stress. Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and stress responses.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Wang P,Zhao Y,Li Z,Hsu CC,Liu X,Fu L,Hou YJ,Du Y,Xie S,Zhang C,Gao J,Cao M,Huang X,Zhu Y,Tang K,Wang X,Tao WA,Xiong Y,Zhu JK

doi

10.1016/j.molcel.2017.12.002

subject

Has Abstract

pub_date

2018-01-04 00:00:00

pages

100-112.e6

issue

1

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(17)30930-9

journal_volume

69

pub_type

杂志文章

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