Signaling from across the way: transactivation of VEGF receptors by HSPGs.


:Heparan sulfate proteoglycans (HSPGs) influence the signaling of many growth factors, and recent work shows that they can promote VEGF signaling in trans from the surface of an adjacent cell. This mode of signaling also alters the activation state and internalization of VEGF receptors.


Mol Cell


Molecular cell


Selleck SB




Has Abstract


2006-05-19 00:00:00














  • ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals.

    abstract::Animal cells have a remarkable capacity to adopt durable and heritable gene expression programs or epigenetic states that define the physical properties and diversity of somatic cell types. The maintenance of epigenetic programs depends on poorly understood pathways that prevent gain or loss of inherited signals. In t...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Ishidate T,Ozturk AR,Durning DJ,Sharma R,Shen EZ,Chen H,Seth M,Shirayama M,Mello CC

    更新日期:2018-05-17 00:00:00

  • Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.

    abstract::Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer, where it is a key therapeutic target. Here we report that, in contrast to estrogen receptor transcription complexes which form within minutes and recycle hourly, the levels of regulatory regions bound by AR complexes ri...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Wang Q,Carroll JS,Brown M

    更新日期:2005-09-02 00:00:00

  • Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

    abstract::The protein kinase B-RAF is mutated in approximately 7% of human cancers. Most mutations are activating, but, surprisingly, a small number have reduced kinase activity. However, the latter can still stimulate cellular signaling through the MEK-ERK pathway because they activate the related family member C-RAF. We exami...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Garnett MJ,Rana S,Paterson H,Barford D,Marais R

    更新日期:2005-12-22 00:00:00

  • Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

    abstract::Forkhead box O (FOXO) transcription factors, the key regulators of cell survival, are negatively controlled through the PI3K-Akt signaling pathway. Phosphorylation of FOXO by Akt leads to cytoplasmic localization and subsequent degradation via the ubiquitin-proteasome system. Here we show a paradigm of FOXO1 regulatio...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Yamagata K,Daitoku H,Takahashi Y,Namiki K,Hisatake K,Kako K,Mukai H,Kasuya Y,Fukamizu A

    更新日期:2008-10-24 00:00:00

  • Balancing BMP signaling through integrated inputs into the Smad1 linker.

    abstract::FGF and other Ras/MAPK pathway activators counterbalance BMP action during neurogenesis, bone formation, and other aspects of vertebrate development and homeostasis. BMP receptors signal through C-terminal phosphorylation and nuclear translocation of the transcription factor Smad1, whereas MAPKs catalyze inhibitory ph...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Sapkota G,Alarcón C,Spagnoli FM,Brivanlou AH,Massagué J

    更新日期:2007-02-09 00:00:00

  • How Rho exerts its muscle on RNA.

    abstract::Rho factor in bacteria terminates transcription by using energy from ATP hydrolysis to forcefully dissociate the transcripts from RNA polymerase. used data from presteady-state ATPase kinetics to support a rational mechanistic model for Rho's action on RNA. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章,评审


    authors: Richardson JP

    更新日期:2006-06-23 00:00:00

  • Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association.

    abstract::The response to endoplasmic reticulum (ER) stress relies on activation of unfolded protein response (UPR) sensors, and the outcome of the UPR depends on the duration and strength of signal. Here, we demonstrate a mechanism that attenuates the activity of the UPR sensor inositol-requiring enzyme 1α (IRE1α). A resident ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Eletto D,Eletto D,Dersh D,Gidalevitz T,Argon Y

    更新日期:2014-02-20 00:00:00

  • Codon Bias as a Means to Fine-Tune Gene Expression.

    abstract::The redundancy of the genetic code implies that most amino acids are encoded by multiple synonymous codons. In all domains of life, a biased frequency of synonymous codons is observed at the genome level, in functionally related genes (e.g., in operons), and within single genes. Other codon bias variants include biase...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Quax TE,Claassens NJ,Söll D,van der Oost J

    更新日期:2015-07-16 00:00:00

  • Y14 and hUpf3b form an NMD-activating complex.

    abstract::Messenger RNAs with premature translation termination codons (PTCs) are degraded by nonsense-mediated mRNA decay (NMD). In mammals, PTCs are discriminated from physiological stop codons by a process thought to involve the splicing-dependent deposition of an exon junction complex (EJC), EJC-mediated recruitment of Upf3...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Gehring NH,Neu-Yilik G,Schell T,Hentze MW,Kulozik AE

    更新日期:2003-04-01 00:00:00

  • ATM breaks into heterochromatin.

    abstract::Heterochromatin is refractory to DNA transactions, including repair. In a recent issue of Molecular Cell, Goodarzi et al. (2008) reveal how the central transducing kinase of the DNA damage response relieves this natural barrier by increasing heterochromatic DNA accessibility. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Fernandez-Capetillo O,Nussenzweig A

    更新日期:2008-08-08 00:00:00

  • Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism.

    abstract::Sterol accumulation in membranes blocks the exit of SCAP from the ER, preventing SREBP cleavage and reducing cholesterol synthesis. Sterols act through SCAP's sterol-sensing domain by an obscure mechanism. Here, we show that addition of cholesterol to ER membranes in vitro causes a conformational change in SCAP, detec...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Brown AJ,Sun L,Feramisco JD,Brown MS,Goldstein JL

    更新日期:2002-08-01 00:00:00

  • Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53.

    abstract::Tumor cells undergo changes in metabolism to meet their energetic and anabolic needs. It is conceivable that mechanisms exist to sense these changes and link them to pathways that eradicate cells primed for cancer development. We report that the tumor suppressor p53 activates a cell death priming mechanism that senses...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Long JS,Crighton D,O'Prey J,Mackay G,Zheng L,Palmer TM,Gottlieb E,Ryan KM

    更新日期:2013-05-09 00:00:00

  • Hsp70- and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants.

    abstract::The activity of the tumor suppressor p53 has to be timed and balanced closely to prevent untimely induction of cell death. The stability of p53 depends on the ubiquitin ligase Mdm2 but also on Hsp70 and Hsp90 chaperones that interact with its DNA binding domain (DBD). Using hydrogen exchange mass spectrometry and bioc...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Boysen M,Kityk R,Mayer MP

    更新日期:2019-05-16 00:00:00

  • SIRTing through breast cancer is just a survivin' game.

    abstract::Loss of endogenous tumor suppression is a critical step on the road to cancer. In a recent paper in Molecular Cell, Wang and colleagues provide evidence that inactivation of the pivotal BRCA1 tumor suppressor disrupts a safeguard gene network that opposes cell proliferation and cell survival. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Luo J,Altieri DC

    更新日期:2008-10-24 00:00:00

  • Distinct signals generate repeating striped pattern in the embryonic parasegment.

    abstract::How repeating striped patterns arise across cellular fields is unclear. To address this we examined the repeating pattern of Stripe (Sr) expression across the parasegment (PS) in Drosophila. This pattern is generated in two steps. First, the ligands Hedgehog (Hh) and Wingless (Wg) subdivide the PS into smaller territo...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Hatini V,DiNardo S

    更新日期:2001-01-01 00:00:00

  • Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis.

    abstract::Proliferating metazoan cells respond to damage that has the potential to cause genomic instability by restricting the cell division cycle or by initiating apoptosis. The molecular mechanisms determining the balance between these responses are not well understood. Here, we show that the apoptotic initiator protease cas...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Allan LA,Clarke PR

    更新日期:2007-04-27 00:00:00

  • The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis.

    abstract::The glycogen synthase kinase-3 (GSK3) family kinases are central cellular regulators highly conserved in all eukaryotes. In Arabidopsis, the GSK3-like kinase BIN2 phosphorylates a range of proteins to control broad developmental processes, and BIN2 is degraded through unknown mechanism upon receptor kinase-mediated br...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Zhu JY,Li Y,Cao DM,Yang H,Oh E,Bi Y,Zhu S,Wang ZY

    更新日期:2017-06-01 00:00:00

  • Stay close to your sister.

    abstract::Yeast Sir2 protein regulates chromatin structure and suppresses recombination at the multiple tandem rDNA array. In the current issue of Cell, Kobayashi and colleagues reinvestigate rDNA dynamics in sir2 strains and find that Sir2 is necessary to recruit cohesins to the array, which influences the nature of rDNA recom...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Reid RJ,Rothstein R

    更新日期:2004-05-21 00:00:00

  • Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

    abstract::MicroRNAs (miRNAs) inhibit mRNA expression in general by base pairing to the 3'UTR of target mRNAs and consequently inhibiting translation and/or initiating poly(A) tail deadenylation and mRNA destabilization. Here we examine the mechanism and kinetics of miRNA-mediated deadenylation in mouse Krebs-2 ascites extract. ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Fabian MR,Mathonnet G,Sundermeier T,Mathys H,Zipprich JT,Svitkin YV,Rivas F,Jinek M,Wohlschlegel J,Doudna JA,Chen CY,Shyu AB,Yates JR 3rd,Hannon GJ,Filipowicz W,Duchaine TF,Sonenberg N

    更新日期:2009-09-24 00:00:00

  • Mitosis hit with an ATM transaction fee: aurora B-mediated activation of ATM during mitosis.

    abstract::In this issue of Molecular Cell, Yang et al. (2011) demonstrate that Aurora B phosphorylates ATM, leading to its mitotic activation and ability to phosphorylate Bub1 and regulate the spindle checkpoint, thus maintaining genomic integrity. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Bihani T,Hinds PW

    更新日期:2011-11-18 00:00:00

  • Transcriptional elongation factor ENL phosphorylated by ATM recruits polycomb and switches off transcription for DSB repair.

    abstract::Transcription is repressed if a DNA double-strand break (DSB) is introduced in close proximity to a transcriptional activation site at least in part by H2A-ubiquitination. While ATM signaling is involved, how it controls H2A-ubiquitination remains unclear. Here, we identify that, in response to DSBs, a transcriptional...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Ui A,Nagaura Y,Yasui A

    更新日期:2015-05-07 00:00:00

  • Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

    abstract::Activation of protein kinase clients by the Hsp90 system is mediated by the cochaperone protein Cdc37. Cdc37 requires phosphorylation at Ser13, but little is known about the regulation of this essential posttranslational modification. We show that Ser13 of uncomplexed Cdc37 is phosphorylated in vivo, as well as in bin...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Vaughan CK,Mollapour M,Smith JR,Truman A,Hu B,Good VM,Panaretou B,Neckers L,Clarke PA,Workman P,Piper PW,Prodromou C,Pearl LH

    更新日期:2008-09-26 00:00:00

  • A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis.

    abstract::The proteolytic activation of the membrane-associated transcription factor pro-sigma(K) is controlled by a signal transduction pathway during sporulation in the bacterium Bacillus subtilis. The pro-sigma(K) processing enzyme SpoIVFB, a membrane-embedded metalloprotease, is held inactive by two other integral-membrane ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Campo N,Rudner DZ

    更新日期:2006-07-07 00:00:00

  • The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

    abstract::Structures of intact receptors with single-pass transmembrane domains are essential to understand how extracellular and cytoplasmic domains regulate association and signaling through transmembrane domains. A chemical and computational method to determine structures of the membrane regions of such receptors on the cell...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Zhu J,Luo BH,Barth P,Schonbrun J,Baker D,Springer TA

    更新日期:2009-04-24 00:00:00

  • Linking activators and basals in transcription: it is all in one family.

    abstract::Analysis of nuclear hormone receptor function in cells derived from xeroderma pigmentosum patients reveals novel links between DNA repair and transcription and points to novel mechanisms of regulating transcriptional regulators. ...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Timmers HT

    更新日期:2002-04-01 00:00:00

  • A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization.

    abstract::X chromosome inactivation (XCI) depends on a noncoding sense-antisense transcript pair, Xist and Tsix. At the onset of XCI, Xist RNA accumulates on one of two Xs, coating and silencing the chromosome in cis. The molecular basis for monoallelic Xist upregulation is not known, though evidence predominantly supports a po...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Sun BK,Deaton AM,Lee JT

    更新日期:2006-03-03 00:00:00

  • The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.

    abstract::Curli are extracellular functional amyloids that are assembled by enteric bacteria during biofilm formation and host colonization. An efficient secretion system and chaperone network ensures that the major curli fiber subunit, CsgA, does not form intracellular amyloid aggregates. We discovered that the periplasmic pro...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Evans ML,Chorell E,Taylor JD,Åden J,Götheson A,Li F,Koch M,Sefer L,Matthews SJ,Wittung-Stafshede P,Almqvist F,Chapman MR

    更新日期:2015-02-05 00:00:00

  • pRB Takes an EZ Path to a Repetitive Task.

    abstract::Repetitive DNA elements are essential for genome function; in this issue of Molecular Cell, Ishak et al. (2016) describe a novel mechanism of epigenetic repression at these elements that requires pRB-dependent recruitment of EZH2. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Sanidas I,Dyson NJ

    更新日期:2016-12-15 00:00:00

  • Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.

    abstract::Key to the pathogenicity of several viruses is activation of the canonical nuclear factor-kappaB (NF-kappaB) transcriptional pathway. Subversion of this tightly regulated mechanism is achieved through the production of host mimetic viral proteins that deregulate the transcription process. One such protein is ks-vFLIP ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Bagnéris C,Ageichik AV,Cronin N,Wallace B,Collins M,Boshoff C,Waksman G,Barrett T

    更新日期:2008-06-06 00:00:00

  • Ribosome structure and activity are altered in cells lacking snoRNPs that form pseudouridines in the peptidyl transferase center.

    abstract::One of the oldest questions in RNA science is the role of nucleotide modification. Here, the importance of pseudouridine formation (Psi) in the peptidyl transferase center of rRNA was examined by depleting yeast cells of 1-5 snoRNAs that guide a total of six Psi modifications. Translation was impaired substantially wi...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: King TH,Liu B,McCully RR,Fournier MJ

    更新日期:2003-02-01 00:00:00