Signaling from across the way: transactivation of VEGF receptors by HSPGs.


:Heparan sulfate proteoglycans (HSPGs) influence the signaling of many growth factors, and recent work shows that they can promote VEGF signaling in trans from the surface of an adjacent cell. This mode of signaling also alters the activation state and internalization of VEGF receptors.


Mol Cell


Molecular cell


Selleck SB




Has Abstract


2006-05-19 00:00:00














  • HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity.

    abstract::We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 forms a robust protein complex with PARP-1 in cells and is recruited to DNA lesions in a PARP-1-dependent manner, but independently of PARP-1 c...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Gibbs-Seymour I,Fontana P,Rack JGM,Ahel I

    更新日期:2016-05-05 00:00:00

  • Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates.

    abstract::Tethering of synaptic vesicles (SVs) to the active zone determines synaptic strength, although the molecular basis governing SV tethering is elusive. Here, we discover that small unilamellar vesicles (SUVs) and SVs from rat brains coat on the surface of condensed liquid droplets formed by active zone proteins RIM, RIM...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Wu X,Ganzella M,Zhou J,Zhu S,Jahn R,Zhang M

    更新日期:2021-01-07 00:00:00

  • Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53.

    abstract::Tumor cells undergo changes in metabolism to meet their energetic and anabolic needs. It is conceivable that mechanisms exist to sense these changes and link them to pathways that eradicate cells primed for cancer development. We report that the tumor suppressor p53 activates a cell death priming mechanism that senses...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Long JS,Crighton D,O'Prey J,Mackay G,Zheng L,Palmer TM,Gottlieb E,Ryan KM

    更新日期:2013-05-09 00:00:00

  • Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300.

    abstract::The transcriptional activity of NF-kappa B is stimulated upon phosphorylation of its p65 subunit on serine 276 by protein kinase A (PKA). The transcriptional coactivator CPB/p300 associates with NF-kappa B p65 through two sites, an N-terminal domain that interacts with the C-terminal region of unphosphorylated p65, an...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Zhong H,Voll RE,Ghosh S

    更新日期:1998-04-01 00:00:00

  • pRB Takes an EZ Path to a Repetitive Task.

    abstract::Repetitive DNA elements are essential for genome function; in this issue of Molecular Cell, Ishak et al. (2016) describe a novel mechanism of epigenetic repression at these elements that requires pRB-dependent recruitment of EZH2. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Sanidas I,Dyson NJ

    更新日期:2016-12-15 00:00:00

  • Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor.

    abstract::The RNA-binding protein Sam68 is implicated in various cellular processes including RNA metabolism, apoptosis, and signal transduction. Here we identify a role of Sam68 in TNF-induced NF-κB activation and apoptosis. We found that Sam68 is recruited to the TNF receptor, and its deficiency dramatically reduces RIP recru...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Ramakrishnan P,Baltimore D

    更新日期:2011-07-22 00:00:00

  • Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

    abstract::Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP sequencing in mouse embryonic stem cells (ESCs). Refined bioinformat...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Bulut-Karslioglu A,De La Rosa-Velázquez IA,Ramirez F,Barenboim M,Onishi-Seebacher M,Arand J,Galán C,Winter GE,Engist B,Gerle B,O'Sullivan RJ,Martens JH,Walter J,Manke T,Lachner M,Jenuwein T

    更新日期:2014-07-17 00:00:00

  • Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1.

    abstract::R loop, a transcription intermediate containing RNA:DNA hybrids and displaced single-stranded DNA (ssDNA), has emerged as a major source of genomic instability. RNaseH1, which cleaves the RNA in RNA:DNA hybrids, plays an important role in R loop suppression. Here we show that replication protein A (RPA), an ssDNA-bind...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Nguyen HD,Yadav T,Giri S,Saez B,Graubert TA,Zou L

    更新日期:2017-03-02 00:00:00

  • A BLAST from the past: ancient origin of human Sm proteins.

    abstract::In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interactions between RNA molec...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Donahue WF,Jarrell KA

    更新日期:2002-01-01 00:00:00

  • A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions.

    abstract::Mutations that lead to splicing defects can have severe consequences on gene function and cause disease. Here, we explore how human genetic variation affects exon recognition by developing a multiplexed functional assay of splicing using Sort-seq (MFASS). We assayed 27,733 variants in the Exome Aggregation Consortium ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Cheung R,Insigne KD,Yao D,Burghard CP,Wang J,Hsiao YE,Jones EM,Goodman DB,Xiao X,Kosuri S

    更新日期:2019-01-03 00:00:00

  • Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization.

    abstract::Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double helices. SMC subunits comprise an ABC ATPase "head" and a "hinge" dimerization domain connected by a 49 nm coiled-coil "arm." The heads undergo ATP-dependent engageme...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Diebold-Durand ML,Lee H,Ruiz Avila LB,Noh H,Shin HC,Im H,Bock FP,Bürmann F,Durand A,Basfeld A,Ham S,Basquin J,Oh BH,Gruber S

    更新日期:2017-07-20 00:00:00

  • The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.

    abstract::The fidelity of chromosome segregation depends on the spindle assembly checkpoint (SAC). In the presence of unattached kinetochores, anaphase is delayed when three SAC components (Mad2, Mad3/BubR1, and Bub3) inhibit Cdc20, the activating subunit of the anaphase-promoting complex (APC/C). We analyzed the role of Cdc20 ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Foster SA,Morgan DO

    更新日期:2012-09-28 00:00:00

  • Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.

    abstract::Mutation and prevalence of pathogenic viruses prompt the development of broad-spectrum antiviral strategies. Viperin is a potent antiviral protein that inhibits a broad range of viruses. Unexpectedly, we found that Viperin protein production in epithelium is defective in response to both viruses and interferons (IFNs)...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Yuan Y,Miao Y,Qian L,Zhang Y,Liu C,Liu J,Zuo Y,Feng Q,Guo T,Zhang L,Chen X,Jin L,Huang F,Zhang H,Zhang W,Li W,Xu G,Zheng H

    更新日期:2020-02-20 00:00:00

  • Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.

    abstract::Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs). However, oxygen is an essential cofactor for mammalian RNR (RRM1/RR...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Foskolou IP,Jorgensen C,Leszczynska KB,Olcina MM,Tarhonskaya H,Haisma B,D'Angiolella V,Myers WK,Domene C,Flashman E,Hammond EM

    更新日期:2017-04-20 00:00:00

  • RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres.

    abstract::Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism of telomere elongation that controls proliferation in aggressive cancers. We show that the disruption of RAD51-associated protein 1 (RAD51AP1) in ALT+ cancer cells leads to generational telomere shortening. This is due to RAD51AP1...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Barroso-González J,García-Expósito L,Hoang SM,Lynskey ML,Roncaioli JL,Ghosh A,Wallace CT,de Vitis M,Modesti M,Bernstein KA,Sarkar SN,Watkins SC,O'Sullivan RJ

    更新日期:2019-10-03 00:00:00

  • Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling.

    abstract::Innate immune responses are critical for the immediate protection against microbial infection. In Drosophila, infection leads to the rapid and robust production of antimicrobial peptides through two NF-kappaB signaling pathways-IMD and Toll. The IMD pathway is triggered by DAP-type peptidoglycan, common to most Gram-n...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Paquette N,Broemer M,Aggarwal K,Chen L,Husson M,Ertürk-Hasdemir D,Reichhart JM,Meier P,Silverman N

    更新日期:2010-01-29 00:00:00

  • ARAP1: a point of convergence for Arf and Rho signaling.

    abstract::We have identified ARAP1 and ARAP2 and examined ARAP1 as a possible link between phosphoinositide-, Arf-, and Rho-mediated cell signaling. ARAP1 contains Arf GAP, Rho GAP, Ankyrin repeat, Ras-associating, and five PH domains. In vitro, ARAP1 had Rho GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent A...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Miura K,Jacques KM,Stauffer S,Kubosaki A,Zhu K,Hirsch DS,Resau J,Zheng Y,Randazzo PA

    更新日期:2002-01-01 00:00:00

  • Modulation of transcription affects mRNP quality.

    abstract::Cotranscriptional loading of proteins onto nascent transcripts contributes to the formation of messenger ribonucleoprotein particles (mRNPs) competent for nuclear export. The transcription machinery is believed to play a pivotal role in mRNP assembly, which is at least partially linked to the function of the THO/TREX ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Jensen TH,Boulay J,Olesen JR,Colin J,Weyler M,Libri D

    更新日期:2004-10-22 00:00:00

  • Yeast Sen1 helicase protects the genome from transcription-associated instability.

    abstract::Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II transcripts. We now show that Sen1 helicase possesses a wider function by restricting the occurrence of RNA:DNA hybrids that may naturally form dur...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Mischo HE,Gómez-González B,Grzechnik P,Rondón AG,Wei W,Steinmetz L,Aguilera A,Proudfoot NJ

    更新日期:2011-01-07 00:00:00

  • Cell signaling and function organized by PB1 domain interactions.

    abstract::The PB1-domain-containing proteins p62, aPKC, MEKK2/MEKK3, MEK5, and Par-6 play roles in critical cell processes like osteoclastogenesis, angiogenesis, and early cardiovascular development or cell polarity. PB1 domains are scaffold modules that adopt the topology of ubiquitin-like beta-grasp folds that interact with e...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Moscat J,Diaz-Meco MT,Albert A,Campuzano S

    更新日期:2006-09-01 00:00:00

  • A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila.

    abstract::Deep orange and carnation are two of the classic eye color genes in Drosophila. Here, we demonstrate that Deep orange is part of a protein complex that localizes to endosomal compartments. A second component of this complex is Carnation, a homolog of Sec1p-like regulators of membrane fusion. Because complete loss of d...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Sevrioukov EA,He JP,Moghrabi N,Sunio A,Krämer H

    更新日期:1999-10-01 00:00:00

  • PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

    abstract::While much research has examined the use of glucose and glutamine by tumor cells, many cancers instead prefer to metabolize fats. Despite the pervasiveness of this phenotype, knowledge of pathways that drive fatty acid oxidation (FAO) in cancer is limited. Prolyl hydroxylase domain proteins hydroxylate substrate proli...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: German NJ,Yoon H,Yusuf RZ,Murphy JP,Finley LW,Laurent G,Haas W,Satterstrom FK,Guarnerio J,Zaganjor E,Santos D,Pandolfi PP,Beck AH,Gygi SP,Scadden DT,Kaelin WG Jr,Haigis MC

    更新日期:2016-09-15 00:00:00

  • A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.

    abstract::In solid tissues of vertebrates, initiation of mitochondrial DNA replication encompasses a broad zone downstream of the major noncoding region (NCR). In contrast, analysis with two-dimensional agarose gel electrophoresis of mitochondrial DNA replication intermediates in cultured human cells revealed initiation concent...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Yasukawa T,Yang MY,Jacobs HT,Holt IJ

    更新日期:2005-06-10 00:00:00

  • Codon reading by tRNAAla with modified uridine in the wobble position.

    abstract::tRNAs reading four-codon families often have a modified uridine, cmo(5)U(34), at the wobble position of the anticodon. Here, we examine the effects on the decoding mechanism of a cmo(5)U modification in tRNA(1B)(Ala), anticodon C(36)G(35)cmo(5)U(34). tRNA(1B)(Ala) reads its cognate codons in a manner that is very simi...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Kothe U,Rodnina MV

    更新日期:2007-01-12 00:00:00

  • Insights into a Mysterious CRISPR Adaptation Factor, Cas4.

    abstract::Cas4 nucleases are conserved factors in many CRISPR systems, yet their molecular role has remained enigmatic. In this issue of Molecular Cell, Shiimori et al. (2018) report that two Cas4 nucleases together determine the size, orientation, and PAM for foreign DNA snippets acquired by CRISPR loci as immunological memory...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Hou Z,Zhang Y

    更新日期:2018-06-07 00:00:00

  • Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.

    abstract::Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage targets are poorly understood. Caspase-2 is activated by the p53 target gene product PIDD (also known as LRDD) in a complex called the Caspase-2-PIDDosome. We show that PIDD expression promotes growth arrest and chemotherapy res...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Oliver TG,Meylan E,Chang GP,Xue W,Burke JR,Humpton TJ,Hubbard D,Bhutkar A,Jacks T

    更新日期:2011-07-08 00:00:00

  • CENP-A targeting moves a step back.

    abstract::In a recent issue of Molecular Cell, Pidoux et al. (2009) and Williams et al. (2009) identify S. pombe Scm3 as the proximate factor in the Cnp1/CENP-A deposition pathway, providing a direct connection to centromere-localized Mis16-Mis18. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Baker RE

    更新日期:2009-02-27 00:00:00

  • Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.

    abstract::Posttranslational modification of proliferating cell nuclear antigen (PCNA), an essential processivity clamp for DNA polymerases, by ubiquitin and SUMO contributes to the coordination of DNA replication, damage tolerance, and mutagenesis. Whereas ubiquitination in response to DNA damage promotes the bypass of replicat...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Papouli E,Chen S,Davies AA,Huttner D,Krejci L,Sung P,Ulrich HD

    更新日期:2005-07-01 00:00:00

  • Herpes simplex virus glycoprotein D bound to the human receptor HveA.

    abstract::Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Carfí A,Willis SH,Whitbeck JC,Krummenacher C,Cohen GH,Eisenberg RJ,Wiley DC

    更新日期:2001-07-01 00:00:00

  • β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4.

    abstract::β-hydroxybutyrate (β-HB) elevation during fasting or caloric restriction is believed to induce anti-aging effects and alleviate aging-related neurodegeneration. However, whether β-HB alters the senescence pathway in vascular cells remains unknown. Here we report that β-HB promotes vascular cell quiescence, which signi...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Han YM,Bedarida T,Ding Y,Somba BK,Lu Q,Wang Q,Song P,Zou MH

    更新日期:2018-09-20 00:00:00