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An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.

Abstract：

:Mammalian cells constantly monitor and respond to a myriad of extracellular signals, often by using cell surface receptors. Two important classes of cell surface receptors include the receptor tyrosine kinases, which recognize peptide growth factors such as insulin, and the integrins, which most often mediate binding to components of the extracellular matrix. We report that the collagens serve as ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinases. The unexpected realization that an extracellular matrix molecule can directly serve as a ligand for receptor tyrosine kinases provides an example of ligands shared by integrins and receptor tyrosine kinases, and this finding seems likely to change prevailing views about the mechanisms by which cells perceive and respond to the extracellular matrix.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Shrivastava A,Radziejewski C,Campbell E,Kovac L,McGlynn M,Ryan TE,Davis S,Goldfarb MP,Glass DJ,Lemke G,Yancopoulos GD

doi

10.1016/s1097-2765(00)80004-0

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

25-34

issue

1

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(00)80004-0

journal_volume

1

pub_type

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