Abstract:
:The oncogenic process often leads to a loss of normal telomere length control, usually as a result of activation of telomerase. Nevertheless, there are also telomerase-independent events that involve a Rad50-dependent recombination mechanism to maintain telomere length. Previous work has implicated the Rb family of proteins in the control of telomere length, and we now demonstrate that the p130 member of the Rb family is critical for telomere length control. p130 interacts specifically with the RINT-1 protein, previously identified as a Rad50-interacting protein. We further show that RINT-1 is essential for telomere length control. We propose that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. Given previous work implicating E2F in the control of telomerase gene expression, these results thus point to complementary roles for the Rb/E2F pathway in the control of telomere length.
journal_name
Mol Celljournal_title
Molecular cellauthors
Kong LJ,Meloni AR,Nevins JRdoi
10.1016/j.molcel.2006.02.016subject
Has Abstractpub_date
2006-04-07 00:00:00pages
63-71issue
1eissn
1097-2765issn
1097-4164pii
S1097-2765(06)00118-3journal_volume
22pub_type
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