Abstract:
:The PB1-domain-containing proteins p62, aPKC, MEKK2/MEKK3, MEK5, and Par-6 play roles in critical cell processes like osteoclastogenesis, angiogenesis, and early cardiovascular development or cell polarity. PB1 domains are scaffold modules that adopt the topology of ubiquitin-like beta-grasp folds that interact with each other in a front-to-back mode to arrange heterodimers or homo-oligomers. The different PB1 domain adaptors provide specificity for PB1 kinases to ensure the effective transmission of cellular signals. Also, recent data suggest that PB1 domains may serve to orchestrate signaling cascades not involving other PB1 domains, such as the MEK5-ERK5 and p62-ERK1 interactions.
journal_name
Mol Celljournal_title
Molecular cellauthors
Moscat J,Diaz-Meco MT,Albert A,Campuzano Sdoi
10.1016/j.molcel.2006.08.002subject
Has Abstractpub_date
2006-09-01 00:00:00pages
631-40issue
5eissn
1097-2765issn
1097-4164pii
S1097-2765(06)00537-5journal_volume
23pub_type
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