Abstract：
:The recent paper by Stadlmann et al. (2017) provides a novel algorithm for glycoproteomics in which complex glycopeptides can be identified in complex mixtures to aid in characterizing both the site of glycosylation and the glycan structure.
journal_name
Mol Celljournal_title
Molecular cellauthors
Cummings RDdoi
10.1016/j.molcel.2017.11.024subject
Has Abstractpub_date
2017-12-07 00:00:00pages
827-829issue
5eissn
1097-2765issn
1097-4164pii
S1097-2765(17)30883-3journal_volume
68pub_type
评论,杂志文章相关文献
MOLECULAR CELL文献大全abstract：:In this issue of Molecular Cell, Vonk et al. (2020) and Thiruvalluvan et al. (2020) identify key chaperones that confer resistance to protein aggregation in neural stem cells and become reduced upon differentiation. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2020.03.028
更新日期：2020-04-16 00:00:00
abstract：:Deubiquitinating enzymes (DUBs) control vital processes in eukaryotes by hydrolyzing ubiquitin adducts. Their activities are tightly regulated, but the mechanisms remain elusive. In particular, the DUB UCH-L5 can be either activated or inhibited by conserved regulatory proteins RPN13 and INO80G, respectively. Here we ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2014.12.039
更新日期：2015-03-05 00:00:00
abstract：:The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. In eukaryotes, CoQ precursors-among nature's most hydrophobic molecules-must somehow be presented to a series of enzymes peripherally associated with the mitochondrial inner membrane. Here, we reveal that t...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2018.11.033
更新日期：2019-02-21 00:00:00
abstract：:Heterochromatin is refractory to DNA transactions, including repair. In a recent issue of Molecular Cell, Goodarzi et al. (2008) reveal how the central transducing kinase of the DNA damage response relieves this natural barrier by increasing heterochromatic DNA accessibility. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2008.07.004
更新日期：2008-08-08 00:00:00
abstract：:Streptolydigin (Stl) is a potent inhibitor of bacterial RNA polymerases (RNAPs). The 2.4 A resolution structure of the Thermus thermophilus RNAP-Stl complex showed that, in full agreement with the available genetic data, the inhibitor binding site is located 20 A away from the RNAP active site and encompasses the brid...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2005.07.020
更新日期：2005-09-02 00:00:00
abstract：:PRDM16 is a transcription co-factor that plays critical roles in development of brown adipose tissue, as well as maintenance of adult hematopoietic and neural stem cells. Here we report that PRDM16 is a histone H3K4 methyltransferase on chromatin. Mutation in the N-terminal PR domain of PRDM16 abolishes the intrinsic ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2016.03.010
更新日期：2016-04-21 00:00:00
abstract：:Both p53 and Mdmx are ubiquitinated and degraded by the same E3 ligase Mdm2; interestingly, however, while p53 is rapidly degraded by Mdm2, Mdmx is a stable protein in most cancer cells. Thus, the mechanism by which Mdmx is degraded by Mdm2 needs further elucidation. Here, we identified the noncoding 5S rRNA as a majo...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2011.08.020
更新日期：2011-09-16 00:00:00
abstract：:AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and biosynthetic processes, in part through its inhibition of the rapamycin-sensitive mTOR (mTORC1) pathway. AMPK phosphorylation of the TSC...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2008.03.003
更新日期：2008-04-25 00:00:00
abstract：:When faced with proteotoxic stress, cells mount adaptive responses to eliminate aberrant proteins. Adaptive responses increase the expression of protein folding and degradation factors to enhance the cellular quality control machinery. However, it is unclear whether and how this augmented machinery acquires new activi...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2018.04.027
更新日期：2018-06-21 00:00:00
abstract：:We have developed a highly parallel strategy, systematic gene-to-phenotype arrays (SGPAs), to comprehensively map the genetic landscape driving molecular phenotypes of interest. By this approach, a complete yeast genetic mutant array is crossed with fluorescent reporters and imaged on membranes at high density and con...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2017.12.016
更新日期：2018-01-18 00:00:00
abstract：:We used computational algorithms to find conserved sequences in the 3' untranslated region (UTR) of transcripts that exhibited rapid decay in primary human T cells and found that the consensus sequence UGUUUGUUUGU, which we have termed a GU-rich element (GRE), was enriched in short-lived transcripts. Using a tet-off r...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2007.11.024
更新日期：2008-02-01 00:00:00
abstract：:Mitochondrial crista structure partitions vital cellular reactions and is precisely regulated by diverse cellular signals. Here, we show that, in Drosophila, mitochondrial cristae undergo dynamic remodeling among distinct subcellular regions and the Parkinson's disease (PD)-linked Ser/Thr kinase PINK1 participates in ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2018.01.026
更新日期：2018-03-01 00:00:00
abstract：:Repetitive DNA elements are essential for genome function; in this issue of Molecular Cell, Ishak et al. (2016) describe a novel mechanism of epigenetic repression at these elements that requires pRB-dependent recruitment of EZH2. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2016.11.035
更新日期：2016-12-15 00:00:00
abstract：:Histone deacetylase 6 (HDAC6) is a tubulin-specific deacetylase that regulates microtubule-dependent cell movement. In this study, we identify the F-actin-binding protein cortactin as a HDAC6 substrate. We demonstrate that HDAC6 binds cortactin and that overexpression of HDAC6 leads to hypoacetylation of cortactin, wh...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2007.05.033
更新日期：2007-07-20 00:00:00
abstract：:To determine whether replicational mutagenesis in the yeast genome is influenced by the positions of active origins, a reporter gene was placed in two orientations at multiple locations within a 39,000 bp region of chromosome III possessing two strong origins. The frequency of mutations resulting from misincorporation...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(02)00567-1
更新日期：2002-07-01 00:00:00
abstract：:The ability to measure human aging from molecular profiles has practical implications in many fields, including disease prevention and treatment, forensics, and extension of life. Although chronological age has been linked to changes in DNA methylation, the methylome has not yet been used to measure and compare human ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2012.10.016
更新日期：2013-01-24 00:00:00
abstract：:The mechanisms by which telomeres are distinguished from DNA double-strand breaks are poorly understood. Here we have defined the minimal requirements for the protection of telomeric DNA ends from nonhomologous end-joining (NHEJ). Neither long, single-stranded overhangs nor t loop formation is essential to prevent NHE...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2007.03.023
更新日期：2007-05-11 00:00:00
abstract：:While much research has examined the use of glucose and glutamine by tumor cells, many cancers instead prefer to metabolize fats. Despite the pervasiveness of this phenotype, knowledge of pathways that drive fatty acid oxidation (FAO) in cancer is limited. Prolyl hydroxylase domain proteins hydroxylate substrate proli...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2016.08.014
更新日期：2016-09-15 00:00:00
abstract：:Angiogenin is a stress-activated ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs). Transfection of natural or synthetic tiRNAs inhibits protein synthesis and triggers the phospho-eIF2α-independent assembly of stress granules (SGs), essential components of ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2011.06.022
更新日期：2011-08-19 00:00:00
abstract：:RanBP2/Nup358 is an essential protein with roles in nuclear transport and mitosis, and is one of the few known SUMO E3 ligases. However, why RanBP2 functions in vivo has been unclear: throughout the cell cycle it stably interacts with RanGAP1*SUMO1 and Ubc9, whose binding sites overlap with the E3 ligase region. Here ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2012.02.017
更新日期：2012-05-11 00:00:00
abstract：:Checkpoint proteins respond to DNA damage by halting the cell cycle until the damage is repaired. In this issue of Molecular Cell, Furuya et al. (2010) provide evidence that checkpoint proteins need to be removed from sites of damage in order to properly repair it. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2010.11.015
更新日期：2010-11-24 00:00:00
abstract：:Despite the importance of retinoic acid (RA) signaling and histone monoubiquitination in determining cell fate, the underlying mechanism linking the two processes is poorly explored. We describe that additional sex comb-like 1 (ASXL1) represses RA receptor activity by cooperating with BRCA1-associated protein 1 (BAP1)...
journal_title：Molecular cell
pub_type： 杂志文章,收录出版
doi：10.1016/j.molcel.2013.06.005
更新日期：2013-07-25 00:00:00
abstract：:MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic. Here, we employed structure-based design with ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2013.11.003
更新日期：2014-01-09 00:00:00
abstract：:Activation of NF-kappaB is regulated via numerous ubiquitin- and proteasome-mediated steps; an important one is processing of the precursor p105 to the p50 active subunit. The mechanisms involved are largely unknown, because this is an exceptional case where the ubiquitin system does not destroy its substrate complete...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2009.01.023
更新日期：2009-02-27 00:00:00
abstract：:Yeast histone H2A is phosphorylated on Ser129 upon DNA damage, an event required for efficient repair. We show that phosphorylation occurs rapidly over a large region around DNA double-strand breaks (DSBs). Histone H4 acetylation is also important for DSB repair, and we found that the NuA4 HAT complex associates speci...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2004.12.003
更新日期：2004-12-22 00:00:00
abstract：:The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their promoter structure, selectivity for either RNA polymerase (Pol) II or III, and because of their unique mechanism of termination that is tightly linked with the pro...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2013.07.003
更新日期：2013-08-22 00:00:00
abstract：:BRAF is an oncogenic protein kinase that drives cell growth and proliferation through the MEK-ERK signaling pathway. BRAF inhibitors have demonstrated antitumor efficacy in melanoma therapy but have also been found to be associated with the development of cutaneous squamous cell carcinomas (cSCCs) in certain patients....
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2013.08.044
更新日期：2013-10-24 00:00:00
abstract：:Protein phase separation by low-complexity, intrinsically disordered domains generates membraneless organelles and links to neurodegeneration. Cellular prion protein (PrPC) contains such domains, causes spongiform degeneration, and is a receptor for Alzheimer's amyloid-β oligomers (Aβo). Here, we show that PrPC separa...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2018.10.009
更新日期：2018-11-01 00:00:00
abstract：:Steroid hormones have rapid nongenomic effects on cell-signaling pathways, but the receptor mechanisms responsible for this are not understood. We have identified a specific polyproline motif in the amino-terminal domain of conventional progesterone receptor (PR) that mediates direct progestin-dependent interaction of...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(01)00304-5
更新日期：2001-08-01 00:00:00
abstract：:Both H4K16 acetylation and H3K4 trimethylation are required for gene activation. However, it is still largely unclear how these modifications are orchestrated by transcriptional factors. Here, we analyzed the mechanism of the transcriptional activation by FOXP3, an X-linked suppressor of autoimmune diseases and cancer...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2011.10.012
更新日期：2011-12-09 00:00:00
