Abstract:
:The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their promoter structure, selectivity for either RNA polymerase (Pol) II or III, and because of their unique mechanism of termination that is tightly linked with the promoter. Recently, we identified the little elongation complex (LEC) in Drosophila that is required for the expression of Pol II-transcribed snRNA genes. Here, using Drosophila and mammalian systems, we provide genetic and molecular evidence that LEC functions in at least two phases of snRNA transcription: an initiation step requiring the ICE1 subunit, and an elongation step requiring ELL.
journal_name
Mol Celljournal_title
Molecular cellauthors
Hu D,Smith ER,Garruss AS,Mohaghegh N,Varberg JM,Lin C,Jackson J,Gao X,Saraf A,Florens L,Washburn MP,Eissenberg JC,Shilatifard Adoi
10.1016/j.molcel.2013.07.003subject
Has Abstractpub_date
2013-08-22 00:00:00pages
493-505issue
4eissn
1097-2765issn
1097-4164pii
S1097-2765(13)00502-9journal_volume
51pub_type
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