The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.

Abstract:

:The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their promoter structure, selectivity for either RNA polymerase (Pol) II or III, and because of their unique mechanism of termination that is tightly linked with the promoter. Recently, we identified the little elongation complex (LEC) in Drosophila that is required for the expression of Pol II-transcribed snRNA genes. Here, using Drosophila and mammalian systems, we provide genetic and molecular evidence that LEC functions in at least two phases of snRNA transcription: an initiation step requiring the ICE1 subunit, and an elongation step requiring ELL.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Hu D,Smith ER,Garruss AS,Mohaghegh N,Varberg JM,Lin C,Jackson J,Gao X,Saraf A,Florens L,Washburn MP,Eissenberg JC,Shilatifard A

doi

10.1016/j.molcel.2013.07.003

subject

Has Abstract

pub_date

2013-08-22 00:00:00

pages

493-505

issue

4

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(13)00502-9

journal_volume

51

pub_type

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