Abstract:
:Impaired glucose tolerance (IGT), known as the prediabetes stage, is usually induced by habits of life or environmental factors. Established IGT animal models are mostly conducted with chemical compounds such as streptozocin or genetic modification. However, the occasion of exposure to these factors in daily life is seldom. The objective of this study was to establish a new animal model of IGT induced by VE deficiency in diet and exposure to radiation. SD rats were treated individually or in combination of these two factors. In the combination group, the calculated insulin sensitivity index decreased; then HOMA-β value increased. Oxidative damage and IGT were observed. Insulin secretion level in perfusate from pancreas response to glucose was characterized by a rapid but reduced first phase and an obviously defective second phase upon pancreas perfusion. Histopathological images demonstrated the pathological changes. Western blotting analysis showed that the insulin signaling pathway was downregulated. The interaction of VE deficiency in diet and exposure to radiation could break the equilibrium of oxidation and antioxidation and result in IGT. More importantly, a new IGT model was successfully established which may be conducive to further research into development of drugs against human IGT.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Guan Y,Cheng Y,Yin Y,Duan J,Wei G,Weng Y,Guo C,Zhu Y,Wang Y,Xi M,Wen Adoi
10.1155/2015/457246subject
Has Abstractpub_date
2015-01-01 00:00:00pages
457246eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:BioMed research international
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pub_type: 杂志文章
doi:10.1155/2016/8370132
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pub_type: 杂志文章
doi:10.1155/2015/361893
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pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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