Ten-Year Retention Rate of Infliximab in Patients with Behçet's Disease-Related Uveitis.

Abstract:

PURPOSE:To evaluate the 10-year drug retention rate of infliximab (IFX) in Behçet's disease (BD)-related uveitis, the effect of a concomitant use of disease modifying anti-rheumatic drugs (DMARDs) on drug survival and differences according to the lines of biologic treatment. METHODS:Cumulative survival rates were studied using the Kaplan-Meier plot, while the Log-rank (Mantel-Cox) test was used to compare survival curves. RESULTS:Forty patients (70 eyes) were eligible for analysis. The drug retention rates at 12-, 24-, 60- and 120-month follow-up were 89.03%, 86.16%, 75.66% and 47.11% respectively. No differences were identified according to the use of concomitant DMARDs (p = 0.20), while a statistically significant difference was observed in relation to the different lines of IFX treatment (p = 0.014). Visual acuity improved from baseline to the last follow-up visit (p = 0.047) and a corticosteroid-sparing effect was observed (p < 0.0001). CONCLUSIONS:IFX retention rate in BD-uveitis is excellent and is not affected by concomitant DMARDs.

journal_name

Ocul Immunol Inflamm

authors

Fabiani C,Sota J,Vitale A,Emmi G,Vannozzi L,Bacherini D,Lopalco G,Guerriero S,Venerito V,Orlando I,Franceschini R,Fusco F,Frediani B,Galeazzi M,Iannone F,Tosi GM,Cantarini L

doi

10.1080/09273948.2017.1391297

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

34-39

issue

1

eissn

0927-3948

issn

1744-5078

journal_volume

27

pub_type

杂志文章
  • Current Practices in Ocular Toxoplasmosis: A Survey of Brazilian Uveitis Specialists.

    abstract:PURPOSE:To describe treatment practices for ocular toxoplasmosis among members of the Brazilian Uveitis Society. METHODS:An online questionnaire sent to specialists, between October 2014 and March 2015. RESULTS:Most respondents (67.9%) treat all active cases. Most specialists consider visual acuity <20/200 (88.2%), s...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2016.1215471

    authors: Morais FB,Arantes TEFE,Muccioli C

    更新日期:2018-01-01 00:00:00

  • Multimodal Imaging in Ocular Tuberculosis.

    abstract::Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1080/09273948.2016.1231332

    authors: Agarwal A,Mahajan S,Khairallah M,Mahendradas P,Gupta A,Gupta V

    更新日期:2017-02-01 00:00:00

  • Occurrence of and Risk Factors for Ocular Hypertension and Secondary Glaucoma in Juvenile Idiopathic Arthritis-associated Uveitis.

    abstract:PURPOSE:To describe the incidence of ocular hypertension (OHT) and secondary glaucoma (SG) in JIA-associated uveitis, identify risk factors for development of these complications, and describe their effect on visual outcomes. METHODS:A retrospective cohort of 108 patients (196 eyes) with JIA-associated uveitis seen ov...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2016.1142573

    authors: Stroh IG,Moradi A,Burkholder BM,Hornbeak DM,Leung TG,Thorne JE

    更新日期:2017-08-01 00:00:00

  • Clinical Follow-up of Patients with Behçet Uveitis after Discontinuation of Infliximab Therapy.

    abstract:PURPOSE:To evaluate the clinical course of patients with Behçet uveitis after discontinuation of infliximab (IFX) therapy. METHODS:Medical records of eight patients who discontinued treatment between 2010 and 2018 were retrospectively analyzed. The main outcome measures were frequency of uveitis attacks per year, best...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1774907

    authors: Köse HC,Yalçındağ N

    更新日期:2020-08-11 00:00:00

  • Effect of Fundus Fluorescein Angiography on Semiautomated Aqueous Flare Measurements.

    abstract:PURPOSE:To evaluate the effects of fluorescein fundus angiography (FFA) on semiautomated aqueous flare measurements. METHODS:Laser flare photometer (LFP) measurements was performed at baseline, 30 min, and 4 h after the intravenous administration of sodium fluorescein dye. FFA was performed immediately after the basel...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1799036

    authors: Halim MS,Onghanseng N,Park JH,Yilmaz M,Segawa A,Ertop M,Hassan M,Tran AN,Aktas Z,Ozdek S,Gurelik G,Do DV,Sepah YJ,Nguyen QD,Hasanreisoglu M

    更新日期:2020-09-23 00:00:00

  • Preliminary Report on Interleukin-22, GM-CSF, and IL-17F in the Pathogenesis of Acute Anterior Uveitis.

    abstract::Purpose: Anterior uveitis is the most common anatomic subset of uveitis. We developed a novel multi-parametric flow cytometry panel to identify immune dysregulation signatures in HLA B27-associated acute anterior uveitis (AAU) and axial spondyloarthritis (AxSpA).Methods: We used fluorescence activated cell sorting to ...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2019.1686156

    authors: Huang JC,Schleisman M,Choi D,Mitchell C,Watson L,Asquith M,Rosenbaum JT

    更新日期:2019-11-25 00:00:00

  • Uveitis referral pattern in a Midwest University Eye Center.

    abstract::We determined the referral pattern and visual prognosis for patients with uveitis at a tertiary university eye center in the Midwestern U.S. over a five-year period. A retrospective chart review was conducted on 853 patients seen in the Department of Ophthalmology and Visual Sciences (DOVS) at Washington University an...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.11.4.287.18270

    authors: Oruc S,Kaplan AD,Galen M,Kaplan HJ

    更新日期:2003-12-01 00:00:00

  • Systemic immune response to Acanthamoeba keratitis in the Chinese hamster.

    abstract::Recrudescence is a common and troubling feature of Acanthamoeba keratitis and suggests that corneal infection with this organism fails to stimulate the systemic immune apparatus. The present study examined the cell-mediated and humoral immune responses to Acanthamoeba keratitis in the Chinese hamster. Corneal infectio...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949709085064

    authors: Van Klink F,Leher H,Jager MJ,Alizadeh H,Taylor W,Niederkorn JY

    更新日期:1997-12-01 00:00:00

  • Pleomorphism of stromal eosinophils in murine experimental onchocercal keratitis.

    abstract::Onchocercal keratitis (river blindness) is one of the leading worldwide causes of blindness. Light microscopic analysis of human specimens and corneal tissue from experimental models has implicated the eosinophil as an important cell in the inflammatory response. Our previous studies in experimental murine onchocercal...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949709116890

    authors: Bardenstein DS,Lass JH,Kazura JW,Pearlman E

    更新日期:1997-09-01 00:00:00

  • Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients.

    abstract::Objective: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin. Material and Methods: Multicenter retrospective study of 38 patients with at least one test, either HCMV-posit...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1662059

    authors: Leleu I,Jhanji V,Touhami S,Westcott M,Angi M,Titah C,Rousseau A,Hamard P,Brasnu E,Manicom T,Blumen-Ohana E,Rozenberg F,Vauloup-Fellous C,Deback C,Labetoulle M,Sahel JA,Bodaghi B,Merabet L,Kobal A,Brignole-Baudouin F

    更新日期:2019-10-23 00:00:00

  • Serpiginous choroiditis in a referral clinic in India: visual field changes and clinical correlates.

    abstract:PURPOSE:To report the visual field changes in patients with serpiginous choroiditis as seen in a referral clinic in India. METHODS:A retrospective noncomparative case series was conducted. Twenty-nine eyes of 17 patients who were diagnosed with serpiginous choroiditis were included in the study. Clinical findings were...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.902473

    authors: Balarabe AH,Biswas J

    更新日期:2014-10-01 00:00:00

  • Atypical Syphilitic Outer Retinitis and Severe Retinal Vasculitis as Onset Manifestations in a Patient with Concurrent HIV and Syphilis Infection.

    abstract:INTRODUCTION:The most distinctive patterns of posterior pole affectation in syphilitic patients are acute posterior placoid chorioretinitis (ASPPC), pseudoretinitis pigmentosa and panuveitis with white focal preretinal opacities. However, outer retinitis is not a common presenting feature in this disease. CASE REPORT:...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2020.1787464

    authors: Vidal-Villegas B,Arcos-Villegas G,Fernández-Vigo JI,Díaz-Valle D

    更新日期:2020-07-23 00:00:00

  • Leptospiral Uveitis: Usefulness of Clinical Signs as Diagnostic Predictors.

    abstract:PURPOSE:To analyze the diagnostic predictive ability of clinical variables. METHODS:Demographic and clinical variables of 172 serologically proven leptospiral uveitis patients were compared with 200 controls of non-leptospiral uveitis. Multiple logistic regression analysis identified diagnostic predictors. A receiver ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2016.1217341

    authors: Sivakumar R,Balakrishnan V,Gowri P,Visalakshi J

    更新日期:2018-01-01 00:00:00

  • Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales' disease.

    abstract:PURPOSE:To report mycobacterial load in the vitreous of patients labeled as having Eales' disease. METHODS:Eighty-eight patients were prospectively enrolled into 3 groups: 28 patients with so-called Eales' disease (group A); 30 positive controls with specific uveitis syndromes (group B), and 30 negative controls (grou...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2012.658134

    authors: Singh R,Toor P,Parchand S,Sharma K,Gupta V,Gupta A

    更新日期:2012-06-01 00:00:00

  • Retinal immunopathology in horses with uveitis.

    abstract:BACKGROUND:Equine uveitis is a spontaneous disorder of horses that can serve as a model for the study of human uveitis. Although the initial presentation is that of an anterior uveitis, retinal involvement has been noted in some cases. We report here the immunohistopathology of retinas from horses with uveitis. METHOD...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.6.4.239.4026

    authors: Kalsow CM,Dwyer AE

    更新日期:1998-12-01 00:00:00

  • Toxoplasmosis, an overview with emphasis on ocular involvement.

    abstract::Toxoplasmosis is a common parasitic zoonosis and an important cause of abortions, mental retardation, encephalitis, blindness, and death worldwide. Although a large body of literature has emerged on the subject in the past decades, many questions about the pathogenesis and treatment of the disease remain unanswered. T...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1076/ocii.10.1.1.10330

    authors: Klaren VN,Kijlstra A

    更新日期:2002-03-01 00:00:00

  • Objective analysis of retinal function in HIV-positive children without retinitis using optical coherence tomography.

    abstract:PURPOSE:To assess the retinal nerve fiber layer thickness in children with human immunodeficiency virus disease without cytomegalovirus retinitis or visual symptoms. METHODS:Thirty-eight eyes of 19 human immunodeficiency virus-positive children (group A) with visual acuity of 20/20 or better, normal color vision testi...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940701375154

    authors: Moschos MM,Mostrou G,Psimenidou E,Spoulou V,Theodoridou M

    更新日期:2007-07-01 00:00:00

  • Semicircular tumor of the iris and uveitis as unilocal manifestation of sarcoidosis.

    abstract:PURPOSE:To describe an unusual manifestation of sarcoidosis as a large tumor of the iris and ciliary body without any other involvement of the body. METHODS:We describe a 20-year-old female presenting with a granulomatous tumor of the right iris and ciliary body and concomitant uveitis. RESULTS:Extensive ocular and s...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/092739490500156

    authors: Maca SM,Firbas U,Hauff W,Zettinig G,Horvat R,Barisani-Asenbauer T

    更新日期:2004-09-01 00:00:00

  • Optical Coherence Tomography Angiography in Uveitic Glaucoma - A Pilot Study.

    abstract::Purpose: To compare vessel density (VD) as measured by optical coherence tomography angiography (OCTA), in uveitic eyes with secondary glaucoma (UG) with VD in uveitic eyes without glaucoma (UV), eyes with primary open-angle glaucoma (POAG), and healthy eyes (HY). Methods: VD was measured at the following segmentation...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1745246

    authors: Lommatzsch C,Bauermann P,Heimes-Bussmann B,Nolte C,Heinz C

    更新日期:2020-11-13 00:00:00

  • Ophthalmic Shingles with Simultaneous Acute Retinal Necrosis in the Opposite Eye.

    abstract:PURPOSE:To report a case of acute retinal necrosis (ARN) occurring in the opposite eye to the ophthalmic shingles eruption. DESIGN:Case report. METHODS:Clinical examination and multimodal imaging review, including ultra-widefield photography and fluorescein angiography (FA). RESULTS:A 49-years-old man attended the U...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1770298

    authors: Battista M,Marchese A,Bordato A,Bandello F,Modorati GM,Miserocchi E

    更新日期:2020-07-09 00:00:00

  • Brimonidine Induced Anterior Uveitis.

    abstract:PURPOSE:To present the largest series reported so far of brimonidine induced granulomatous anterior uveitis. METHODS:Retrospective chart review of patients with chronic glaucoma on treatment with brimonidine presenting with anterior uveitis. RESULTS:19 eyes of 12 patients with chronic glaucoma developed anterior uvei...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2015.1037845

    authors: Beltz J,Zamir E

    更新日期:2016-01-01 00:00:00

  • Is There a True Neuroretinitis in Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) Syndrome ?

    abstract::Purpose : To clarify whether a true neuroretinitis is part of  idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome.Methods : Critical literature review.Results : Neuroretinitis has been considered as a prominent feature of IRVAN syndrome. It has been described as late diffuse optic  disc stai...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1836234

    authors: Khairallah M,Khochtali S,Ksiaa I

    更新日期:2020-12-17 00:00:00

  • Neuro-Behcet Disease and Ocular Inflammation: A Case Report and Literature Review.

    abstract::Purpose: To describe a case of panuveitis with occlusive vasculitis leading to the diagnosis of neuro-Behcet disease (NBD) and discuss the relationship between uveitis and NBD. Methods: Case report with a literature review of ocular inflammation in NBD. Results: A 26-year-old woman with a seven-month history of recurr...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1787461

    authors: Patel SA,Okeagu C,Jones K,Chaudhry A,Berkenstock MK

    更新日期:2020-08-19 00:00:00

  • Does Pharmaceutical Compounding of Vascular Endothelial Growth Factor Inhibitors for Intravitreal Use Alter the Risk of Post-injection Endophthalmitis?

    abstract:PURPOSE:To investigate the safety of pharmaceutically compounded syringes for intravitreal administration of anti-vascular endothelial growth factor (anti-VEGF) drugs. METHODS:Single center, retrospective chart review. From 2015 to 2019, Oslo University Hospital, Norway gradually implemented pharmaceutical compounding...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1820530

    authors: Blom K,Bragadóttir R,Sivertsen MS,Moe MC,Jørstad ØK

    更新日期:2020-10-07 00:00:00

  • Clinical Profile of Herpes Zoster Ophthalmicus in a South Indian Patient Population.

    abstract:PURPOSE:To analyze and compare the clinical profile of herpes zoster ophthalmicus (HZO) patients in a South Indian patient population aged <60 years and ≥60 years and determine the risk factors for recurrence of ocular inflammation. METHODS:Retrospective study of 249 cases between 2006 and 2016 from two tertiary refer...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1381272

    authors: Babu K,Mahendradas P,Sudheer B,Kawali A,Parameswarappa DC,Pal V,Philips M

    更新日期:2018-01-01 00:00:00

  • Ocular lesions in acute disseminated tuberculosis.

    abstract:PURPOSE:To determine the prevalence of ocular involvement in patients with acute disseminated tuberculosis and to assess the findings associated with ocular involvement. METHODS:Assessment of all intensive care (ICU) admissions with a differential diagnosis of mycobacterial sepsis during a period of one year, with a d...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/092739490500354

    authors: Mehta S

    更新日期:2004-12-01 00:00:00

  • Outcomes of treatment with immunomodulatory therapy in patients with corticosteroid-resistant juvenile idiopathic arthritis-associated chronic iridocyclitis.

    abstract:PURPOSE:To describe the clinical outcome of patients with juvenile idiopathic arthritis (IA)-associated chronic iridocyclitis unresponsive to conventional therapy, in whom inflammation was eventually controlled using immunomodulatory therapy (IMT), and to determine if patients treated early with IMT have better visual ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940590951061

    authors: Yu EN,Meniconi ME,Tufail F,Baltatzis S,Foster CS

    更新日期:2005-09-01 00:00:00

  • Retinal Pigment Epithelium Tear after Immunosuppressive Treatment for Sarcoidosis-related Choroidal Granuloma.

    abstract:PURPOSE:To describe the formation of a retinal pigment epithelial (RPE) tear following immunosuppressive treatment of a large choroidal granuloma in a patient with sarcoidosis-related panuveitis. METHODS:A 25-year-old woman presented with bilateral sarcoidosis-related panuveitis and optic disc edema in both eyes with ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2016.1180402

    authors: Knickelbein JE,Wei M,Nussenblatt RB,Sen HN

    更新日期:2017-12-01 00:00:00

  • Diagnostic Markers in Ocular Sarcoidosis in A High TB Endemic Population - A Multicentre Study.

    abstract:AIM:To look at markers to differentiate ocular sarcoidosis from ocular tuberculosis in a high TB endemic population. MATERIALS & METHODS:Retrospective multicenter study involving seven tertiary eyecare centers in India between July 2016 to December 2016. Demographic, clinical and laboratory data were retrieved from re...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1778733

    authors: Babu K,Biswas J,Agarwal M,Mahendradas P,Bansal R,Rathinam SR,Basu S,Ganesh SK,Konana VK,Vedhanayaki R,Philips M,Choudhary T

    更新日期:2020-09-01 00:00:00

  • Evolving "Diagnostic" Criteria for Axial Spondyloarthritis in the Context of Anterior Uveitis.

    abstract::Anterior uveitis is far more common than intermediate, posterior or panuveitis. About 50% of patients with acute anterior uveitis are HLA B27+. Those who are HLA B27+ are highly likely to have associated back, joint, or tendon disease. The majority of patients with acute anterior uveitis and inflammatory low back pain...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.3109/09273948.2016.1158277

    authors: Rosenbaum JT

    更新日期:2016-08-01 00:00:00