Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients.

Abstract:

:Objective: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin. Material and Methods: Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc. Results: Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. PCR and GWc were positive for HCMV in 50% and 96.2% of the eyes, respectively. Glaucoma was diagnosed in 50% of eyes. Treatment was oral valganciclovir in about half of the patients. Other treatments were intravenous ganciclovir and/or ganciclovir topical ointment and/or intravitreal ganciclovir. Conclusions: No obvious association of specific clinical features with individual ethnicity could be identified. We found a high rate of glaucoma in all ethnic groups. There was a delay in diagnosis and specific treatment of HCMV in most patients.

journal_name

Ocul Immunol Inflamm

authors

Leleu I,Jhanji V,Touhami S,Westcott M,Angi M,Titah C,Rousseau A,Hamard P,Brasnu E,Manicom T,Blumen-Ohana E,Rozenberg F,Vauloup-Fellous C,Deback C,Labetoulle M,Sahel JA,Bodaghi B,Merabet L,Kobal A,Brignole-Baudouin F

doi

10.1080/09273948.2019.1662059

subject

Has Abstract

pub_date

2019-10-23 00:00:00

pages

1-9

eissn

0927-3948

issn

1744-5078

pub_type

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