Intravitreal Adalimumab for the Control of Breakthrough Intraocular Inflammation.

Abstract:

PURPOSE:Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. METHODS:Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy. RESULTS:Seven eyes of four patients with Adamantiades-Behçet disease panuveitis were included and all were maintained on systemic adalimumab for 7.3 months (range 3-11) with inflammation controlled for 4.1 months (range 2-10) before breakthrough uveitis. The total number of attacks was 13 over 24.5 months (range 12-30). Resolution of attack was defined as return to baseline visual acuity with resolution of inflammatory markers. Three attacks resolved after only one injection and 10 attacks required an average of 2.4 injections (range 2-3). No systemic or ocular complications were noted. CONCLUSIONS:Intravitreal adalimumab warrants further investigation as a potentially effective, practical and safe adjunctive therapy for the control of breakthrough inflammation in select patients maintained on systemic adalimumab.

journal_name

Ocul Immunol Inflamm

authors

Kheir WJ,Mehanna CJ,Abdul Fattah M,Al Ghadban S,El Sabban M,Mansour AM,Hamam RN

doi

10.1080/09273948.2017.1335756

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1206-1211

issue

8

eissn

0927-3948

issn

1744-5078

journal_volume

26

pub_type

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