Impact of Inflammation and Treatment on Self-reported Quality of Life in Patients with Non-acute Vogt-Koyanagi-Harada Disease (VKHD).

Abstract:

:Aims: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients.Methods: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for ≥12 months since acute disease onset, with systematic evaluation and predefined treatment protocols. VR- and HR-QoL aspects were assessed by VFQ-25 and SF-36 questionnaires, respectively. Associations between the questionnaire's subscale item scores with inflammation and systemic medical therapies were assessed.Results: After generalized linear model analysis, worse VA, severe fundus changes, fluctuation of VA and fluctuation of anterior chamber cells impacted negatively on VR-QoL items. Higher cumulative total dose of corticosteroids and use of immunosuppressive therapy impacted negatively on both questionnaires.Conclusion: Worse VA, clinical inflammation and systemic treatment have a significant impact on VR- and HR-QoL questionnaires. Subclinical choroidal inflammation did not seem to impact QoL.

journal_name

Ocul Immunol Inflamm

authors

Souto FMS,Missaka RFBG,Magalhães BM,Caetano VMC,Takiuti JT,Lavezzo MM,Sakata VM,Oyamada MK,Hirata CE,Yamamoto JH

doi

10.1080/09273948.2019.1668431

subject

Has Abstract

pub_date

2019-10-31 00:00:00

pages

1-12

eissn

0927-3948

issn

1744-5078

pub_type

杂志文章
  • Sympathetic ophthalmia following vitrectomy for endophthalmitis after intravitreal bevacizumab.

    abstract:PURPOSE:To describe a case of sympathetic ophthalmia following vitrectomy for endophthalmitis after an intravitreal injection of bevacizumab. DESIGN:Retrospective case report. METHODS:An 84-year-old male developed sympathetic ophthalmia 4 months after vitrectomy for endophthalmitis following an intravitreal injection...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940802409951

    authors: Sisk RA,Davis JL,Dubovy SR,Smiddy WE

    更新日期:2008-09-01 00:00:00

  • Treatment of severe ocular hypotony in AIDS patients with cytomegalovirus retinitis and cidofovir-associated uveitis.

    abstract:OBJECTIVE:To describe the medical treatment of severe ocular hypotony in HIV-seropositive patients with cytomegalovirus retinitis and cidofovir-associated uveitis. PATIENTS AND METHODS:Two HIV-seropositive patients with cytomegalovirus retinitis and cidofovir-associated uveitis complicated by severe ocular hypotony we...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.9.3.211.3968

    authors: Accorinti M,Ciapparoni V,Pirraglia MP,Pivetti-Pezzi P

    更新日期:2001-09-01 00:00:00

  • Targeting tissue factor for immunotherapy of choroidal neovascularization by intravitreal delivery of factor VII-Fc chimeric antibody.

    abstract:PURPOSE:ICON is a fusion protein composed of factor VII, the natural ligand for tissue factor, conjugated to the Fc domain of a human IgG1 immunoglobulin. It binds to the tissue factor expressed on neovascular endothelia and initiates a cytolytic immune attack that destroys the neovascular tissue. We previously showed ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940601147760

    authors: Tezel TH,Bodek E,Sönmez K,Kaliappan S,Kaplan HJ,Hu Z,Garen A

    更新日期:2007-01-01 00:00:00

  • Clinical Course and Outcomes of Pediatric Tubercular Uveitis in North India.

    abstract:PURPOSE:To analyze the clinical features, course, management, and outcomes of tubercular (TB) uveitis in the pediatric population and assess the response to anti-tubercular therapy (ATT). METHODS:Hospital records of children (≤16 years) from a large tertiary-care institute between January 2001 and December 2015 were r...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1296579

    authors: Kaur S,Aggarwal K,Agarwal A,Suri D,Gupta A,Singh R,Bansal R,Singh S,Singh N,Gupta A,Gupta V

    更新日期:2018-01-01 00:00:00

  • Diagnostic Challenges in Inflammatory Choroidal Neovascular Membranes.

    abstract:PURPOSE:To describe the clinical presentations of inflammatory choroidal neovascular membranes (CNVMs) and factors leading to their delayed diagnosis. METHODS:Retrospective analysis of chart records and digital images of 60 patients (73 eyes) with inflammatory CNVM (January 1998 to December 2013) to obtain demographic...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2016.1160128

    authors: Bansal R,Bansal P,Gupta A,Gupta V,Dogra MR,Singh R,Katoch D

    更新日期:2017-08-01 00:00:00

  • Expanding the Clinical Spectrum of Multiple Evanescent White Dot Syndrome with Overlapping Multifocal Choroiditis.

    abstract:PURPOSE:To evaluate multifocal evanescent white dot syndrome (MEWDS) patients with and without overlapping multifocal choroiditis (MFC). METHODS:Thirty-four patients diagnosed between November 2008 and August 2018 at 2 hospitals were retrospectively reviewed. Multimodal imaging including optical coherence tomography a...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1795206

    authors: Kang HG,Kim TY,Kim M,Byeon SH,Kim SS,Koh HJ,Lee SC,Lee CS

    更新日期:2020-09-01 00:00:00

  • Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients.

    abstract::Purpose: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. Methods: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in ARMC9....

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1523438

    authors: Ohno T,Meguro A,Takeuchi M,Yamane T,Teshigawara T,Kitaichi N,Horie Y,Namba K,Ohno S,Nakao K,Sakamoto T,Sakai T,Nakano T,Keino H,Okada AA,Takeda A,Fukuhara T,Mashimo H,Ohguro N,Oono S,Enaida H,Okinami S,Mizuki

    更新日期:2019-01-01 00:00:00

  • Tear secretory IgA: evaluation of usefulness as a diagnostic marker in herpetic keratitis.

    abstract::In a South Indian study, an 'in-house' enzyme-linked immunosorbent assay (ELISA) was developed to evaluate the potential of herpes simplex virus (HSV)-specific tear secretory IgA (sIgA) in the diagnosis of herpes simplex keratitis (HSK). The presence of HSV-specific tear sIgA was found to be diagnostic in 20.28% of ca...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.7.2.61.4023

    authors: Pramod NP,Dhevahi E,Sudhamathi K,Kannan K,Thyagarajan SP

    更新日期:1999-06-01 00:00:00

  • Evaluation of the Anterior Segment Parameters of the Patients with Scleroderma.

    abstract:PURPOSE:To evaluate corneal parameters of scleroderma (SC) patients by Pentacam-HR. METHODS:Twenty-two eyes of 22 SC patients and 33 eyes of 33 control subjects were enrolled. All participants underwent Pentacam (Pentacam-HR, Oculus, Germany) evaluation. Both SC and control groups were divided into two subgroups as dr...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2015.1115079

    authors: Şahin M,Yüksel H,Şahin A,Cingü AK,Türkcü FM,Kaya S,Yazmalar L,Batmaz İ

    更新日期:2017-04-01 00:00:00

  • Comparative Analysis of Anterior Chamber Flare Grading between Clinicians with Different Levels of Experience and Semi-automated Laser Flare Photometry.

    abstract:PURPOSE:To assess correlation for anterior chamber flare grading between clinicians with different levels of experience and with semi-automated flare reading in a cohort of patients with heterogeneous uveitic entities. METHODS:Fifty-nine observations from 36 patients were recorded and analyzed for statistical associat...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.990042

    authors: Agrawal R,Keane PA,Singh J,Saihan Z,Kontos A,Pavesio CE

    更新日期:2016-01-01 00:00:00

  • Systemic immune response to Acanthamoeba keratitis in the Chinese hamster.

    abstract::Recrudescence is a common and troubling feature of Acanthamoeba keratitis and suggests that corneal infection with this organism fails to stimulate the systemic immune apparatus. The present study examined the cell-mediated and humoral immune responses to Acanthamoeba keratitis in the Chinese hamster. Corneal infectio...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949709085064

    authors: Van Klink F,Leher H,Jager MJ,Alizadeh H,Taylor W,Niederkorn JY

    更新日期:1997-12-01 00:00:00

  • Uveal Effusion Associated with Presumed Viral Encephalitis.

    abstract::Background Uveal effusion is a rare disease that is characterized by exudative detachment of the ciliary body and choroid. Herein, we report a rare case of uveal effusion associated with viral encephalitis, which resolved following the treatment of the viral encephalitis and administration of corticosteroids. Case pre...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2020.1797110

    authors: Lee DH,Kim TY,Lee SC,Kim M

    更新日期:2020-08-20 00:00:00

  • Optical coherence tomography for classification and clinical evaluation of macular edema in patients with uveitis.

    abstract:PURPOSE:To study use of optical coherence tomography (OCT) for macular edema in uveitis. METHODS:In total, 44 patients with uveitis and macular edema underwent OCT. Data obtained were correlated with anatomic type, duration of uveitis, and visual acuity (VA). RESULTS:Both cystoid macular edema (CME) and diffuse macul...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940802187466

    authors: Iannetti L,Accorinti M,Liverani M,Caggiano C,Abdulaziz R,Pivetti-Pezzi P

    更新日期:2008-07-01 00:00:00

  • Use of a high infusion rate to prevent posterior dislocation of fluocinolone acetonide implant during surgical removal.

    abstract:PURPOSE:To describe a strategy for reducing the risk of posterior dislocation of a fluocinolone implant during exchange or removal. DESIGN:Case report and in vitro model. METHODS:Description of a surgical case and an in vitro experiment evaluating the role of infusion pressure in maintaining implant stability in surg...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2011.553980

    authors: Wan W,Stewart JM

    更新日期:2011-06-01 00:00:00

  • Endophthalmitis in HIV Infection.

    abstract::Purpose: The role of HIV infection in exogenous and endogenous endophthalmitis has not been clarified. We aim to assess the potential role of HIV as a risk factor or a poor prognostic feature in this sight-threatening condition. Methods: Literature review. Review of evidence: Evidence for endophthalmitis in HIV patien...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1699580

    authors: Tsirouki T,Steffen J,Dastiridou A,Praidou A,Androudi S

    更新日期:2020-10-02 00:00:00

  • Semicircular tumor of the iris and uveitis as unilocal manifestation of sarcoidosis.

    abstract:PURPOSE:To describe an unusual manifestation of sarcoidosis as a large tumor of the iris and ciliary body without any other involvement of the body. METHODS:We describe a 20-year-old female presenting with a granulomatous tumor of the right iris and ciliary body and concomitant uveitis. RESULTS:Extensive ocular and s...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/092739490500156

    authors: Maca SM,Firbas U,Hauff W,Zettinig G,Horvat R,Barisani-Asenbauer T

    更新日期:2004-09-01 00:00:00

  • Subcutaneous Tocilizumab for Cystoid Macular Edema Secondary to Juvenile Idiopathic Arthritis (JIA)-associated Uveitis: A Case Report.

    abstract::Purpose: To report a case of cystoid macular edema (CME) secondary to juvenile idiopathic arthritis (JIA)-associated uveitis. Case report: 26-year-old female patient presented with CME in both eyes. CME became refractory and TCZ-IV was initiated. After 12 infusions was stopped because grade 1 neuropenia developed. On ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1644350

    authors: Adán A,Moll-Udina A,Ramirez J,Llorenç V

    更新日期:2019-10-07 00:00:00

  • Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis.

    abstract::Scleritis is a severe and destructive inflammatory eye disease characterized by extensive extracellular matrix degradation. As in rheumatoid arthritis (RA), tissue destruction in scleritis may be mediated in part by matrix metalloproteinases such as collagenase (MMP-1) and stromelysin (MMP-3) which are normally kept i...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949509069111

    authors: Girolamo ND,McCluskey PJ,Lloyd A,Wakefield D

    更新日期:1995-01-01 00:00:00

  • Multimodal Imaging in Ocular Tuberculosis.

    abstract::Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1080/09273948.2016.1231332

    authors: Agarwal A,Mahajan S,Khairallah M,Mahendradas P,Gupta A,Gupta V

    更新日期:2017-02-01 00:00:00

  • Atypical presentation of multiple evanescent white dot syndrome (MEWDS).

    abstract:PURPOSE:To present fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and microperimetry (MP) findings of a patient with multiple evanescent white dot syndrome (MEWDS). METHODS:Observational case report. RESULTS:A 30-year-old woman with blurry vision was referred for evaluation. Fundus examination r...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940802026060

    authors: Yenerel NM,Kucumen B,Gorgun E,Dinc UA

    更新日期:2008-05-01 00:00:00

  • Fluorodeoxyglucose positron emission tomography for the diagnosis of sarcoidosis in patients with unexplained chronic uveitis.

    abstract:PURPOSE:To assess the value of fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in patients with unexplained chronic uveitis. METHODS:Retrospective review of 19 (18)F-FDG PET scans. All patients had normal chest CT. In the final analysis, the authors used criteria similar to the criteria of ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940902788221

    authors: Seve P,Billotey C,Janier M,Grange JD,Broussolle C,Kodjikian L

    更新日期:2009-05-01 00:00:00

  • Tuberculin Skin Testing Induces Bilateral Tuberculous Uveitis in a Junior High School Student.

    abstract::We report a rare case of bilateral tuberculous uveitis associated with tuberculin skin testing (TST) in an otherwise healthy junior high school student. A 12-year-old boy presented with severely decreased vision in both eyes and a history of an intradermal PPD (purified protein derivative) skin test 12 days earlier. T...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2020.1778731

    authors: Zhao H,Peng X

    更新日期:2020-08-12 00:00:00

  • Long-Term Intravitreal Dexamethasone Implant Outcomes in Uveitis.

    abstract::Purpose: To describe the long-term clinical outcomes in a cohort of uveitic eyes treated with the intravitreal dexamethasone implant (Ozurdex; Allergan, Inc).Methods: Seventy-nine (63 patients) receiving 134 implant injections over 82 months were included. Indication, visual acuity (VA), intraocular pressure (IOP), vi...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1578380

    authors: Alba-Linero C,Sala-Puigdollers A,Romero B,Llorenç V,Adan A,Zarranz-Ventura J

    更新日期:2020-01-01 00:00:00

  • Stenotrophomonas maltophilia Endophthalmitis after cataract extraction.

    abstract:PURPOSE:To report the clinical course, treatment response, and prognosis of Stenotrophomonas maltophilia endophthalmitis following cataract extraction. METHODS:The clinical records of six cases of S. maltophilia endophthalmitis after cataract extraction were retrospectively reviewed. Data were collected for surgical c...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940590950981

    authors: Karakurt A,Abdik O,Sengün A,Karadağ R,Saricaoğlu S,Sarikatipoğlu HY,Hasiripi H

    更新日期:2006-02-01 00:00:00

  • Intravitreal Adalimumab for the Control of Breakthrough Intraocular Inflammation.

    abstract:PURPOSE:Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. METHODS:Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy. RESULTS:Seven eyes of four patients w...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1335756

    authors: Kheir WJ,Mehanna CJ,Abdul Fattah M,Al Ghadban S,El Sabban M,Mansour AM,Hamam RN

    更新日期:2018-01-01 00:00:00

  • Glaucoma Secondary to Uveitis in Children in a Tertiary Care Referral Center.

    abstract::Purpose: To study outcome of secondary glaucoma in pediatric uveitis patients. Methods: Retrospective analysis of records of uveitis patients ≤16 years. Results: Of 182 pediatric uveitis patients, secondary glaucoma was seen in 48 patients (75 eyes, 26.23%) with female preponderance (F:M-29:19) . JIA was the most comm...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1411517

    authors: Gautam Seth N,Yangzes S,Thattaruthody F,Singh R,Bansal R,Raj S,Kaushik S,Gupta V,Pandav SS,Ram J,Gupta A

    更新日期:2019-01-01 00:00:00

  • Effect of Fundus Fluorescein Angiography on Semiautomated Aqueous Flare Measurements.

    abstract:PURPOSE:To evaluate the effects of fluorescein fundus angiography (FFA) on semiautomated aqueous flare measurements. METHODS:Laser flare photometer (LFP) measurements was performed at baseline, 30 min, and 4 h after the intravenous administration of sodium fluorescein dye. FFA was performed immediately after the basel...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1799036

    authors: Halim MS,Onghanseng N,Park JH,Yilmaz M,Segawa A,Ertop M,Hassan M,Tran AN,Aktas Z,Ozdek S,Gurelik G,Do DV,Sepah YJ,Nguyen QD,Hasanreisoglu M

    更新日期:2020-09-23 00:00:00

  • Sterile endophthalmitis following intravitreal injection of triamcinolone acetonide.

    abstract:PURPOSE:To investigate clinical findings and ocular characteristics of sterile endophthalmitis following intravitreal injection (IVI) of triamcinolone for the treatment of macular edema. METHODS:IVI is an institutional practice at our hospital. From March 2002 to January 2003, a total of 21 IVIs of triamcinolone aceto...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940590951007

    authors: Wang LC,Yang CM

    更新日期:2005-07-01 00:00:00

  • Post-streptococcal vasculitis.

    abstract:PURPOSE:To report a case of post-streptococcal retinal vasculitis. DESIGN:Review of a case. METHODS:Review of patient chart and fluorescein angiography. RESULTS:A 17 year old African American female presented with moderate vitritis and macular edema in the right eye and retinal vessel sheathing in both eyes. CONCLU...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940701799163

    authors: Reddy UP,Albini TA,Banta JT,Davis JL

    更新日期:2008-01-01 00:00:00

  • Syphilitic uveitis in a Singaporean population.

    abstract:PURPOSE:To report the presentations of syphilitic uveitides in Singapore. METHODS:Retrospective noncomparative observational case series of 18 eyes from 12 patients with ocular syphilis between 2004 and 2009. RESULTS:Patients were mainly male (91.7%). Median age was 49.5 (24-84) years. Initial visual acuity varied fr...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2013.829106

    authors: Yap SC,Tan YL,Chio MT,Teoh SC

    更新日期:2014-02-01 00:00:00