Long-Term Intravitreal Dexamethasone Implant Outcomes in Uveitis.

Abstract:

:Purpose: To describe the long-term clinical outcomes in a cohort of uveitic eyes treated with the intravitreal dexamethasone implant (Ozurdex; Allergan, Inc).Methods: Seventy-nine (63 patients) receiving 134 implant injections over 82 months were included. Indication, visual acuity (VA), intraocular pressure (IOP), vitreous haze score (VHS), central retinal thickness (CRT), time to reinjection, systemic treatments, and complications data were recorded.Results: The cumulative probability of VA improvement was 80% at 1 month and 90% at 12 months, and it was maintained until 60 months. Eyes with baseline vitritis (VHS >0.5; 68%) had a probability of VHS improvement of 33% at 1 month, 75% at 12 months, and 85% at 60 months. The probability of CRT improvement was 33% at 1 month, 75% at 12 months, and 85% at 60 months. The most frequent adverse event was moderate IOP elevation (≥25 mmHg) in 30.3%, no cases of retinal detachment or endophthalmitis were observed.Conclusions: The dexamethasone implant provides favorable VA, CRT, and VHS long-term outcomes in uveitis with a reduced rate of severe adverse events.

journal_name

Ocul Immunol Inflamm

authors

Alba-Linero C,Sala-Puigdollers A,Romero B,Llorenç V,Adan A,Zarranz-Ventura J

doi

10.1080/09273948.2019.1578380

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

228-237

issue

2

eissn

0927-3948

issn

1744-5078

journal_volume

28

pub_type

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