Abstract:
:Purpose: To describe the long-term clinical outcomes in a cohort of uveitic eyes treated with the intravitreal dexamethasone implant (Ozurdex; Allergan, Inc).Methods: Seventy-nine (63 patients) receiving 134 implant injections over 82 months were included. Indication, visual acuity (VA), intraocular pressure (IOP), vitreous haze score (VHS), central retinal thickness (CRT), time to reinjection, systemic treatments, and complications data were recorded.Results: The cumulative probability of VA improvement was 80% at 1 month and 90% at 12 months, and it was maintained until 60 months. Eyes with baseline vitritis (VHS >0.5; 68%) had a probability of VHS improvement of 33% at 1 month, 75% at 12 months, and 85% at 60 months. The probability of CRT improvement was 33% at 1 month, 75% at 12 months, and 85% at 60 months. The most frequent adverse event was moderate IOP elevation (≥25 mmHg) in 30.3%, no cases of retinal detachment or endophthalmitis were observed.Conclusions: The dexamethasone implant provides favorable VA, CRT, and VHS long-term outcomes in uveitis with a reduced rate of severe adverse events.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Alba-Linero C,Sala-Puigdollers A,Romero B,Llorenç V,Adan A,Zarranz-Ventura Jdoi
10.1080/09273948.2019.1578380subject
Has Abstractpub_date
2020-01-01 00:00:00pages
228-237issue
2eissn
0927-3948issn
1744-5078journal_volume
28pub_type
杂志文章abstract::Purpose: Anterior uveitis is the most common anatomic subset of uveitis. We developed a novel multi-parametric flow cytometry panel to identify immune dysregulation signatures in HLA B27-associated acute anterior uveitis (AAU) and axial spondyloarthritis (AxSpA).Methods: We used fluorescence activated cell sorting to ...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2019.1686156
更新日期:2019-11-25 00:00:00
abstract::Purpose:: Fungal endophthalmitis following pars plana vitrectomy with silicone oil tamponade is an infrequent entity. Filamentous fungi like aspergillus are generally associated with endophthalmitis. Mucor is a rarely implicated pathogen in cases of endophthalmitis with only two reported cases in medical literature. B...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2018.1518462
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS:The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1247871
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The purpose of our study was to evaluate the potential efficacy and safety of intravitreal ranibizumab in patients with pseudophakic cystoid macular edema (CME). METHODS:This retrospective study comprised 7 eyes with CME treated with intravitreal ranibizumab. Patients were examined at 1 week and 1 month after ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.898775
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To present a case of tubercular serpiginous-like choroiditis (SLC) with previously unreported choroidal findings on enhanced depth imaging OCT (EDI-OCT). DESIGN:Case report. METHODS:A 60-year-old female presented with decreased vision. Serpiginous choroidopathy was diagnosed. Laboratory workup revealed an inf...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.964421
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To compare the efficacy of devR and MPB64 PCR in the diagnosis of intraocular tuberculosis. METHODS:Prospective, nonrandomized study. Seventy-five patients were enrolled in 3 groups. Group A had 25 patients with presumed intraocular tubercular uveitis, group B had 25 controls with specific uveitis other than t...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.981550
更新日期:2015-02-01 00:00:00
abstract::Potent antiretroviral therapy can result in substantial improvement in the immune function of patients with AIDS. In some patients with preexisting cytomegalovirus (CMV) retinitis, a consequence of this improved immune function is increased intraocular inflammation. This phenomenon, termed 'immune recovery uveitis', i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1076/ocii.7.3.215.4010
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:Longitudinal evaluation of acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) following diagnosis and treatment of metastatic melanoma. METHODS:Case report of a 47-year-old male with unknown primary metastatic melanoma and AEPPVM monitored before and during melanoma treatment using cl...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1813782
更新日期:2020-10-06 00:00:00
abstract:PURPOSE:To investigate the safety and efficacy of daclizumab (Zenapax, humanized anti-Tac, HAT) in controlling the ocular manifestations of Behçet's disease. DESIGN:Randomized, placebo-controlled, double-masked clinical trial. PARTICIPANTS:Seventeen participants with Behçet's disease experiencing at least two prior o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1080/09273940701299370
更新日期:2007-03-01 00:00:00
abstract::Background Uveal effusion is a rare disease that is characterized by exudative detachment of the ciliary body and choroid. Herein, we report a rare case of uveal effusion associated with viral encephalitis, which resolved following the treatment of the viral encephalitis and administration of corticosteroids. Case pre...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1797110
更新日期:2020-08-20 00:00:00
abstract::Purpose: To analyse the association between skin score with corneal biomechanics and dry eye tests in systemic sclerosis (SSc). Methods: 112 cases (limited SSc (lcSSc), n=50; diffuse SSc (dcSSc), n=32; controls, n=30) were included in the study. Corneal hysteresis (CH), corneal resistance factor (CRF), Schirmer 1, 2 ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1501496
更新日期:2019-01-01 00:00:00
abstract:UNLABELLED:Abstract Purpose: To characterize and analyze ocular involvement associated with visual loss in a cohort of patients with rickettsial disease. METHODS:Retrospective study of 16 eyes of 14 patients. RESULTS:Mean initial visual acuity (VA) was 20/63 (range, 20/800-20/25). White retinal lesions infiltrating i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.848907
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To report the outcomes of cataract surgery in ocular cicatricial pemphigoid (OCP). SETTING:L. V. Prasad Eye Institute, Hyderabad, India. DESIGN:Retrospective, interventional case series. METHODS:Patients diagnosed with OCP who had undergone cataract surgery were included. Staging of disease, type of surgery,...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.819106
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To report a challenging case of unilateral choroidal effusion. METHODS:A case report about patient who presented with unilateral choroidal effusion and who was taking sulfonamides. Patient has been under care of a multidisciplinary team of uveitis consultant, ocular oncology consultant, and systemic oncology c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770300
更新日期:2020-07-09 00:00:00
abstract:PURPOSE:To describe whole-body 18-fluorodeoxyglucose (FDG) positron emission tomography/computed radiographic tomography (PET-CT) imaging of ophthalmic patients with systemic sarcoidosis. METHODS:Four systemic sarcoidosis patients were evaluated with PET-CT for staging. Two had been treated for conjunctival melanoma a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802596567
更新日期:2009-03-01 00:00:00
abstract::Purpose: The purpose of this study is to explore the effects of dihydrotestosterone (DHT) on lipopolysaccharide (LPS)-induced proinflammatory cytokine release in human ocular surface epithelial cells exposed to LPS and LPS-binding protein (LBP).Methods: Immortalized human corneal, conjunctival, and meibomian gland epi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1686155
更新日期:2019-11-18 00:00:00
abstract::Purpose: To report a case of choroidal neovascularization (CNV), which was not obvious with dye angiography but was detected with optical coherence tomography angiography (OCTA).Methods: A 50-year-old female presented with decreased vision in her right eye. Funduscopic examination revealed a swollen hyperemic disc, pe...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1754862
更新日期:2020-05-27 00:00:00
abstract::Purpose: To evaluate multimodal imaging findings in longitudinal follow-up of a patient with presumed tuberculous serpiginous-like choroiditis (TB-SLC). Method: We evaluated multimodal imaging in a 62-year-old male with TB-SLC. Correlation between optical coherence tomography angiography (OCTA), swept-source OCT (SS-O...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1501497
更新日期:2019-01-01 00:00:00
abstract::The surgical technique and immediate results following posterior chamber IOL implantation after cataract extraction in eight children suffering from chronic uveitis are described. In all cases, improvement of the visual acuity and a better control of the intraocular inflammatory processes could be achieved after surge...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949309086555
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To report the clinical course, treatment response, and prognosis of Stenotrophomonas maltophilia endophthalmitis following cataract extraction. METHODS:The clinical records of six cases of S. maltophilia endophthalmitis after cataract extraction were retrospectively reviewed. Data were collected for surgical c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940590950981
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:To describe scleral changes in chronic VKH. METHODS:Medical records of patients with chronic VKH were retrospectively reviewed. Change of scleral architecture was defined as progressive posterior bowing on OCT, axial length elongation, and/or increased myopia more than -1.0 D, not explicable by other etiologie...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1057600
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To report a case of acute retinal necrosis (ARN) occurring in the opposite eye to the ophthalmic shingles eruption. DESIGN:Case report. METHODS:Clinical examination and multimodal imaging review, including ultra-widefield photography and fluorescein angiography (FA). RESULTS:A 49-years-old man attended the U...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770298
更新日期:2020-07-09 00:00:00
abstract:PURPOSE:To investigate the incidence and risk factors of secondary glaucoma among uveitis patients. METHODS:Retrospective review of medical records of 642 patients (1220 eyes). RESULTS:Glaucoma was diagnosed in 169 (13.9%) eyes and was most common in eyes with anterior uveitis (19.1%) (p < 0.001). HLA-B27-positive an...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1047036
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:To present a case of autoimmune retinopathy resulting from a mutation in the autoimmune regulator (AIRE) gene. DESIGN:Case study. METHODS:Case review. RESULTS:Mild improvement of goldmann visual field following treatment with systemic and local immunosuppression. CONCLUSIONS:There are a limited number of ca...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2012.754906
更新日期:2013-04-01 00:00:00
abstract::Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2016.1231332
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To investigate demographic, clinical features and complications of Italian patients with ocular Behçet's disease (BD) over time. METHODS:Retrospective study of 385 patients examined from 1968 to 2011, 265 of whom had follow-up ≥ 12 months. RESULTS:A significant increase in the proportion of females (p = 0.03)...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1094095
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To compare histopathological and biochemical effects of the anti-TNF-alpha drugs adalimumab and infliximab in a uveitis experimental model. METHODS:Histopathological evaluation was performed 24 h after endotoxin (200 microg into the footpad) and drug administration, as well as biochemical analysis of oxidative...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903521964
更新日期:2010-06-01 00:00:00
abstract::Uveitis is an intraocular inflammation that can be caused by infection, autoimmune disease, trauma or malignancy. It is a serious cause of visual handicap and therapy is targeted at: removal of possible infectious agents, the immunological processes that lead to or sustain the inflammation and finally to prevent or tr...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949609079654
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To analyze the diagnostic predictive ability of clinical variables. METHODS:Demographic and clinical variables of 172 serologically proven leptospiral uveitis patients were compared with 200 controls of non-leptospiral uveitis. Multiple logistic regression analysis identified diagnostic predictors. A receiver ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1217341
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To describe the clinical presentations of inflammatory choroidal neovascular membranes (CNVMs) and factors leading to their delayed diagnosis. METHODS:Retrospective analysis of chart records and digital images of 60 patients (73 eyes) with inflammatory CNVM (January 1998 to December 2013) to obtain demographic...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2016.1160128
更新日期:2017-08-01 00:00:00