Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients.

Abstract:

:Purpose: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. Methods: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in ARMC9. We also performed imputation analysis of the ARMC9 region and 195 imputed SNPs were included in the statistical analysis. Results: We observed an increased frequency of the A allele of rs28690417 in patients compared with controls (P = 0.0097, odds ratio (OR) = 1.46). The A allele had a dominant effect on VKH disease risk (P = 0.011, OR = 1.51). However, these significant differences disappeared after Bonferroni correction (corrected P > 0.05). The remaining 201 SNPs did not show any significant association with disease risk. Conclusions: Our study suggests that ARMC9 variants do not play a critical role in the development of VKH disease.

journal_name

Ocul Immunol Inflamm

authors

Ohno T,Meguro A,Takeuchi M,Yamane T,Teshigawara T,Kitaichi N,Horie Y,Namba K,Ohno S,Nakao K,Sakamoto T,Sakai T,Nakano T,Keino H,Okada AA,Takeda A,Fukuhara T,Mashimo H,Ohguro N,Oono S,Enaida H,Okinami S,Mizuki

doi

10.1080/09273948.2018.1523438

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

699-705

issue

5

eissn

0927-3948

issn

1744-5078

journal_volume

27

pub_type

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