Abstract:
PURPOSE:To evaluate the patterns of acute and recurrent acute anterior uveitis (AAU) in a metropolitan tertiary referral center. METHODS:A retrospective medical record review of a total of 241 patients with AAU presenting to Sydney Eye Hospital between June 2009 and June 2011 was performed. Patients who underwent typing for the HLA-B27 antigen were included in this study. Ninety-five patients were HLA-B27-positive and 146 were HLA-B27-negative. RESULTS:Seronegative spondyloarthropathy (n = 26, 11%) was the most common systemic disease association in the HLA-B27 positive patients. Posterior synechiae was the most common complication. Complications of cataract, ocular hypertension, secondary glaucoma, and cystoid macular edema were more common in HLA-B27-negative patients with a recurrent disease course. The most common newly diagnosed systemic disease was sarcoid (n = 7), followed by ankylosing spondylitis (n = 4), tuberculosis (n = 2), and syphilis (n = 2). CONCLUSIONS:This case series emphasizes the key role of the ophthalmologist in identifying previously undiagnosed systemic diseases. It also highlights the importance of differentiating latent from active infection, particularly tuberculosis and syphilis, through directed investigations to assess the risk to the patient of reactivation with systemic treatment. This study adds further evidence to our understanding that HLA-B27-negative patients have a poor visual prognosis.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Karaconji T,Maconochie Z,McCluskey Pdoi
10.3109/09273948.2012.745882subject
Has Abstractpub_date
2013-04-01 00:00:00pages
108-14issue
2eissn
0927-3948issn
1744-5078journal_volume
21pub_type
杂志文章abstract:PURPOSE:To compare QuantiFERON®-TB Gold and tuberculin skin testing as diagnostic tests for intraocular tuberculosis in HIV positive and negative patients. METHODS:A prospective study evaluating two different tests to help diagnose intraocular tuberculosis. RESULTS:Thirty-five of 106 patients (33.0%) were diagnosed w...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1327078
更新日期:2018-01-01 00:00:00
abstract::Aims: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients.Methods: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for ≥12 months since acute dise...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1668431
更新日期:2019-10-31 00:00:00
abstract:PURPOSE:To report bilateral ocular hypertension in association with ocular sarcoidosis. METHODS:Case note review of patients with a diagnosis of sarcoidosis-related uveitis. RESULTS:The authors identified 5 patients who fulfilled the diagnostic criteria for ocular sarcoidosis and who had intraocular pressures of > 40...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940701732230
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:To evaluate the safety and efficacy of intravitreal triamcinolone acetonide (TA) for treating macular edema secondary to non-infectious uveitis. METHODS:Retrospective review of sixteen patients (20 eyes) with chronic cystoid macular edema (CME) as a consequence of controlled intermediate uveitis, posterior ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940590933511
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:The authors observed that eyes with acute fibrinous central serous chorioretinopathy (CSC) masquerading active choroiditis had a "dark spot" within the yellow fibrinous deposit. The present study aims to describe this sign as a clinical indicator of acute serofibrinous exudative detachment, thus helping to diff...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.765015
更新日期:2013-06-01 00:00:00
abstract::Purpose: To report a case of cystoid macular edema (CME) secondary to juvenile idiopathic arthritis (JIA)-associated uveitis. Case report: 26-year-old female patient presented with CME in both eyes. CME became refractory and TCZ-IV was initiated. After 12 infusions was stopped because grade 1 neuropenia developed. On ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1644350
更新日期:2019-10-07 00:00:00
abstract:PURPOSE:To report a case of subretinal fibrosis and uveitis syndrome in association with ectodermal dysplasia. METHODS:Chart review of a patient with subretinal fibrosis and uveitis syndrome and ectodermal dysplasia. RESULTS:The authors identified one case of a patient with the diagnoses of subretinal fibrosis and uv...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903168670
更新日期:2009-09-01 00:00:00
abstract::Purpose: To emphasize the different manifestations of ocular involvement in Whipple disease with challenge in establishing the diagnosis as clinical, laboratory, and histological features could mimic other uveitis entities. Methods: Case reports of three patients. Results: The first patient was an African male sufferi...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2018.1518461
更新日期:2019-01-01 00:00:00
abstract::Recrudescence is a common and troubling feature of Acanthamoeba keratitis and suggests that corneal infection with this organism fails to stimulate the systemic immune apparatus. The present study examined the cell-mediated and humoral immune responses to Acanthamoeba keratitis in the Chinese hamster. Corneal infectio...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949709085064
更新日期:1997-12-01 00:00:00
abstract:AIM:The objective of this study is to describe the surgical outcomes of patients of HIV on HAART who underwent surgery for CMV retinitis related retinal detachment. METHOD AND MATERIALS:A retrospective analysis of the medical records of 40 eyes of 35 consecutive HIV positive patients who underwent surgical repair for ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,多中心研究
doi:10.3109/09273948.2014.999376
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The aim of the present study was to evaluate retinal and choroidal thicknesses in children with familial Mediterranean fever (FMF). METHODS:Thirty patients with FMF and 28 healthy controls were included in the study. The thicknesses of the retina and choroid of each subject's right eye were measured at the fov...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.916309
更新日期:2014-12-01 00:00:00
abstract::Background Uveal effusion is a rare disease that is characterized by exudative detachment of the ciliary body and choroid. Herein, we report a rare case of uveal effusion associated with viral encephalitis, which resolved following the treatment of the viral encephalitis and administration of corticosteroids. Case pre...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1797110
更新日期:2020-08-20 00:00:00
abstract:PURPOSE:Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and is associated with considerable morbidity. The aim of this study was to examine the risk factors associated with uveitis in oligoarticular JIA. METHODS:We conducted a chart review of 86 patients with oligoarticu...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.841495
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:To investigate the association between keratoconus (KC) and allergic diseases. METHODS:In a prospective age- and sex-matched case--control study clinical data of 885 KC patients and 1526 controls were evaluated regarding the presence of various allergic diseases. Severity of KC and ophthalmic parameters of KC ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2016.1145697
更新日期:2017-06-01 00:00:00
abstract::Introduction: Uveitis is an important cause of blindness and ocular morbidity in the world. The patterns of uveitis have not been well characterized in sub-Saharan Africa. Purpose: To describe the characteristics of uveitis among patients presenting to Jimma University Department of Ophthalmology (JUDO) from July 2013...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1644348
更新日期:2020-10-02 00:00:00
abstract:PURPOSE:To describe a strategy for reducing the risk of posterior dislocation of a fluocinolone implant during exchange or removal. DESIGN:Case report and in vitro model. METHODS:Description of a surgical case and an in vitro experiment evaluating the role of infusion pressure in maintaining implant stability in surg...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2011.553980
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:Tear lysozyme and tear lactoferrin are enzymes synthesized by the lacrimal gland. Their concentration in human tears reflects tear gland function. Tear gland dysfunction can lead to ocular surface disease. We developed a colorimetric lysozyme assay. The objective of this study was to determine the diagnostic po...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.7.1.7.8108
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:To investigate the safety and efficacy of daclizumab (Zenapax, humanized anti-Tac, HAT) in controlling the ocular manifestations of Behçet's disease. DESIGN:Randomized, placebo-controlled, double-masked clinical trial. PARTICIPANTS:Seventeen participants with Behçet's disease experiencing at least two prior o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1080/09273940701299370
更新日期:2007-03-01 00:00:00
abstract::The authors present a polymerase chain reaction method for rapid and direct diagnosis of herpetic intraocular infections using small volume samples of intraocular fluid from 29 patients with various intraocular inflammatory diseases and 24 controls with senile cataract. Of six patients with early acute retinal necrosi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949309086545
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:Ipilimumab, a monoclonal antibody directed against the immune protein cytotoxic T-lymphocyte antigen-4 (CTLA-4), characteristically induces side effects called "immune-related adverse events" (IRAE). Although ophthalmic involvement is rare, we report 7 cases of eye and orbit complications related to ipilimumab ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.3109/09273948.2014.1001858
更新日期:2016-01-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) induced by immunization of male Lewis rats with bovine S-antigen (S-Ag) is prevented by injection of S-Ag into the testis prior to immunization. This protection of animals is due to the induction of systemic immunotolerance or immunosuppression, which the authors designate o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949509085041
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:The study was to evaluate the diagnostic efficacy of nested polymerase chain reaction (nPCR) using primers targeting B1 gene of Toxoplasma gondii (T. gondii) with Witmer Desmonts coefficient (WDC) technique in intraocular fluids of clinically suspected toxoplasma retino choroiditis (TRC) patients. MATERIALS ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940500545692
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:To analyze the clinical features, course, management, and outcomes of tubercular (TB) uveitis in the pediatric population and assess the response to anti-tubercular therapy (ATT). METHODS:Hospital records of children (≤16 years) from a large tertiary-care institute between January 2001 and December 2015 were r...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1296579
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Relapsing ocular inflammation occurs in about 70% of patients with Behçet's disease (BD) and can lead to permanent loss of vision. Neovascularization of the optic disc (NVD) or elsewhere in the retina (NVE) is a relatively uncommon but severe complication that lacks standardized treatment. METHODS:We report on...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1332228
更新日期:2019-01-01 00:00:00
abstract::Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2016.1231332
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To describe the formation of a retinal pigment epithelial (RPE) tear following immunosuppressive treatment of a large choroidal granuloma in a patient with sarcoidosis-related panuveitis. METHODS:A 25-year-old woman presented with bilateral sarcoidosis-related panuveitis and optic disc edema in both eyes with ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1180402
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To define the indocyanine green (ICG) and fundus fluorescein angiographic (FFA) features of Behçet's disease. METHODS:The study included 49 eyes of 25 patients (19 males, 6 females; mean age: 34.1 years; age range: 14-68 years) with Behçet's disease and active ocular involvement that fulfilled the criteria of ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940490518757
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To investigate serum inflammatory factors in patients with idiopathic choroidal vascularization (CNV), including vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNFα), Interleukin1-beta (IL1-β), IgG, IgA, IgM, IgE, 50% hemolytic unit of complement (CH50), complement C3, complement C4 a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2010.483315
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. METHODS:Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy. RESULTS:Seven eyes of four patients w...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1335756
更新日期:2018-01-01 00:00:00
abstract:AIM:To report 2 cases of idiopathic anterior uveitis with coexistent myasthenia gravis. MATERIALS AND METHODS:Retrospective case reports. RESULTS:A 60-year-old male and a 40-year-old male presented with chronic nongranulomatous anterior uveitis of unknown etiology. The latter had a history of hypothyroidism. During f...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.3109/09273948.2012.726687
更新日期:2013-01-01 00:00:00