Biologic Treatment Options for Retinal Neovascularization in Behçet's Disease.

Abstract:

PURPOSE:Relapsing ocular inflammation occurs in about 70% of patients with Behçet's disease (BD) and can lead to permanent loss of vision. Neovascularization of the optic disc (NVD) or elsewhere in the retina (NVE) is a relatively uncommon but severe complication that lacks standardized treatment. METHODS:We report on the therapeutic use of anti-TNF monoclonal antibodies for BD-associated NVD and NVE in one pediatric patient (subcutaneous adalimumab) and one young man (intravenous infliximab). Also, we review the previously published experience on biologic therapeutic options, namely anti-TNF agents and interferon-alpha in a total of three and eight patients, respectively. RESULTS:A fast-onset therapeutic effect was observed in both patients leading to complete regression of neovascularizations. CONCLUSIONS:Both options may lead to regression of neovascularization, thus preventing loss of vision, but comparative studies need to determine the optimal treatment for this sight-threatening complication of BD.

journal_name

Ocul Immunol Inflamm

authors

Markomichelakis NN,Aissopou EK,Maselos S,Tugal-Tutkun I,Sfikakis PP

doi

10.1080/09273948.2017.1332228

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

51-57

issue

1

eissn

0927-3948

issn

1744-5078

journal_volume

27

pub_type

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