Abstract：
:Tacrolimus (FK506) is effective in Japanese endogenous posterior uveitis (EPU), but there is limited data on its role in refractory EPU where cyclosporin A (CsA) toxicity/resistance develops. This open prospective clinical study aimed to assess the efficacy and adverse effects of low-dose FK506 therapy in western patients with refractory EPU where CsA resistance or toxicity has developed. Patients with CsA resistant/toxic EPU were started on low-dose (< 0.10 mg/kg/day) FK506 therapy. Immunosuppressive efficacy was assessed by visual acuity, binocular indirect ophthalmoscopy (BIO) scores, and change in clinical features. Adverse effects were assessed by routine biochemical tests (including serum creatinine) and symptoms. Seven patients (13 eyes), aged (mean +/- SD) 37.5 +/- 14.8 years, were recruited with previous CsA nephrotoxicity as the main indication and prior duration of EPU of (mean +/- SD) 13.1 +/- 7.3 years. Behçet's disease was the commonest diagnosis. FK506 therapy was maintained at 0.06 +/- 0.02 mg/kg/day, trough level of 8.7 +/- 1.8 ng/ml, in combination with low-dose prednisolone (0.11 +/- 0.04 mg/kg/day) in all patients for a mean duration of 8.7 months (range 1.0-17.7). From baseline (for 11 eyes with meaningful follow-up), visual acuity was maintained in nine eyes and BIO score improved in nine eyes. No major adverse effects developed, with only a 7.5 +/- 6.5% maximum increase in serum creatinine in patients with previous CsA-induced nephrotoxicity. Minor adverse effects (especially mild hyperglycaemia and neurological symptoms) were common and usually well tolerated, except for two patients in whom drug withdrawal was necessary, thus producing therapeutic failure. Low-dose FK506 is effective in refractory EPU as CsA-rescue therapy, and should be considered earlier in the evolution of refractory EPU.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Kilmartin DJ,Forrester JV,Dick ADdoi
10.1076/ocii.6.2.101.4051subject
Has Abstractpub_date
1998-06-01 00:00:00pages
101-9issue
2eissn
0927-3948issn
1744-5078journal_volume
6pub_type
杂志文章abstract：PURPOSE:To evaluate the clinical outcome and safety of adalimumab in patients with Vogt-Koyanagi-Harada (VKH) disease. METHODS:VKH patients treated with adalimumab seen at the University of Buenos Aires were reviewed. Main outcome measures were visual acuity, anterior segment inflammation, optic nerve inflammation (ON...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2016.1236969
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:To describe the formation of a retinal pigment epithelial (RPE) tear following immunosuppressive treatment of a large choroidal granuloma in a patient with sarcoidosis-related panuveitis. METHODS:A 25-year-old woman presented with bilateral sarcoidosis-related panuveitis and optic disc edema in both eyes with ...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2016.1180402
更新日期：2017-12-01 00:00:00
abstract：:Purpose: To review early withdrawal of immunomodulatory therapy (IMT) for birdshot retinochoroidopathy (BSRC). Design: Retrospective case-series of sixteen patients with Human-leukocyte-antigen-A29-positive BSRC treated with IMT ≥ 1 year and discontinued prior to achieving durable remission, observed ≥ 6 months off IM...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2018.1506040
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:To demonstrate that fundus autofluorescence (FAF) imaging aides the diagnosis of rubella retinopathy (RR). METHODS:Four patients with sensorineural hearing loss underwent ophthalmic exams, electro-retinogram testing (ERG), and FAF in both eyes. Fluorescein angiogram (FA) was performed in one case. RESULTS:Sal...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.3109/09273940903118634
更新日期：2009-11-01 00:00:00
abstract：:Purpose: To compare toll-like receptors 2 (TLR2) and 4 (TLR4) expression in cells of corneal and conjunctival epithelium between unilateral KC patients and control subjects. Methods: Prospective cross-sectional case-control study, including 50 unilateral KC patients and 20 control subjects. TLR2 and TLR4 expression wa...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2018.1511813
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:To report 2 cases of branch retinal artery occlusion (BRAO) associated with Behçet disease (BD). DESIGN:Small case series. METHODS:Review of two patients' charts, fluorescein angiography, and optical coherence tomography (OCT). RESULTS:The authors report two young patients, diagnosed with BD, who developed d...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.3109/09273948.2011.582219
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:To analyze the clinical features, course, management, and outcomes of tubercular (TB) uveitis in the pediatric population and assess the response to anti-tubercular therapy (ATT). METHODS:Hospital records of children (≤16 years) from a large tertiary-care institute between January 2001 and December 2015 were r...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2017.1296579
更新日期：2018-01-01 00:00:00
abstract：:Background: Rapid and timely diagnosis of tubercular uveitis (TBU) is of paramount importance to save these eyes from blindness. The present study was, therefore, undertaken to carry out a comparative evaluation of Gene Xpert MTB/RIF (Xpert), MTBDRplus and Multiplex PCR (MPCR) for the diagnosis of TBU. These tests wer...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2019.1655581
更新日期：2019-10-03 00:00:00
abstract：:Aim: To analyze the incidence, microbiological profile, risk factors, and outcomes in eyes with osteo-odonto keratoprosthesis (OOKP) developing endophthalmitis. Methods & material: Retrospective review of medical records of patients presenting between 2003 and 2013 with OOKP and endophthalmitis was undertaken after ob...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2020.1770807
更新日期：2020-10-07 00:00:00
abstract：PURPOSE:To investigate demographic, clinical features and complications of Italian patients with ocular Behçet's disease (BD) over time. METHODS:Retrospective study of 385 patients examined from 1968 to 2011, 265 of whom had follow-up ≥ 12 months. RESULTS:A significant increase in the proportion of females (p = 0.03)...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.3109/09273948.2015.1094095
更新日期：2017-02-01 00:00:00
abstract：:Purpose : To clarify whether a true neuroretinitis is part of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome.Methods : Critical literature review.Results : Neuroretinitis has been considered as a prominent feature of IRVAN syndrome. It has been described as late diffuse optic disc stai...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2020.1836234
更新日期：2020-12-17 00:00:00
abstract：:Purpose: To analyze the pattern of laboratory investigations of uveitis at a tertiary referral eye care center in Singapore.Methods: Retrospective analysis of 2040 uveitis cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database over a 12-year period (2004 - 2015).Results: Patients with...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2018.1535080
更新日期：2020-01-01 00:00:00
abstract：AIM:The objective of this study is to describe the surgical outcomes of patients of HIV on HAART who underwent surgery for CMV retinitis related retinal detachment. METHOD AND MATERIALS:A retrospective analysis of the medical records of 40 eyes of 35 consecutive HIV positive patients who underwent surgical repair for ...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章,多中心研究
doi：10.3109/09273948.2014.999376
更新日期：2015-01-01 00:00:00
abstract：:Purpose: Anterior uveitis is the most common anatomic subset of uveitis. We developed a novel multi-parametric flow cytometry panel to identify immune dysregulation signatures in HLA B27-associated acute anterior uveitis (AAU) and axial spondyloarthritis (AxSpA).Methods: We used fluorescence activated cell sorting to ...
journal_title：Ocular immunology and inflammation
pub_type： 信件
doi：10.1080/09273948.2019.1686156
更新日期：2019-11-25 00:00:00
abstract：PURPOSE:To report the clinical course, treatment response, and prognosis of Stenotrophomonas maltophilia endophthalmitis following cataract extraction. METHODS:The clinical records of six cases of S. maltophilia endophthalmitis after cataract extraction were retrospectively reviewed. Data were collected for surgical c...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273940590950981
更新日期：2006-02-01 00:00:00
abstract：PURPOSE:To report a case of post-streptococcal retinal vasculitis. DESIGN:Review of a case. METHODS:Review of patient chart and fluorescein angiography. RESULTS:A 17 year old African American female presented with moderate vitritis and macular edema in the right eye and retinal vessel sheathing in both eyes. CONCLU...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273940701799163
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:To describe a patient with a tolerated cilium in the anterior chamber. METHODS:A 15-year-old girl, referred with a 5-year trauma history, was examined. A cilium was noted in the anterior chamber without any inflammation during routine ophthalmological examination. RESULTS:The cilium was removed surgically and...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章,评审
doi：10.1076/ocii.11.1.73.15576
更新日期：2003-03-01 00:00:00
abstract：PURPOSE:Manifestations of Systemic lupus erythematosus are protean and the eye can get affected in more than a third of the cases. This study was conducted to evaluate the spectrum of ocular manifestation among Nepalese patients diagnosed with Systemic lupus erythematosus. METHODS:In this hospital based cross-sectiona...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.3109/09273948.2011.610023
更新日期：2011-12-01 00:00:00
abstract：:Several subjective and arbitrary grading methods are used in assessing cell and flare in uveitis. Clinicians are in need of an objective method of determining and monitoring active inflammation. We studied the correlation of changes in macular thickness between the visits and compared the change to visual acuity (VA),...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273940802702587
更新日期：2009-07-01 00:00:00
abstract：PURPOSE:Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. METHODS:Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy. RESULTS:Seven eyes of four patients w...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
abstract：PURPOSE:To review a case of bilateral diffuse chorioretinopathy as a presenting sign of juvenile dermatomyositis (JDM) and review the literature regarding retinal manifestations associated with this disease. METHODS:Review of case record and literature regarding retinal manifestations related to juvenile dermatomyosit...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章,评审
doi：10.1080/09273948.2017.1305421
更新日期：2018-01-01 00:00:00
abstract：:The standardization of Uveitis Nomenclature (SUN) Working Group recently affirmed the importance of an anatomic classification of uveitis, endorsing the anatomic clasiffication scheme proposed by the International Uveitis Study Group (IUSG). The group however pointed out and addressed ambiguities in the IUSG system, a...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.3109/09273940903348835
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:An HLA-DQ1 association has been suspected in patients who develop Propionibacterium acnes endophthalmitis following cataract surgery. New techniques exist which may help to define this association. MATERIALS AND METHODS:Patients with culture-proven P. acnes endophthalmitis following cataract surgery were HL...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.3109/09273949609069124
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To describe whole-body 18-fluorodeoxyglucose (FDG) positron emission tomography/computed radiographic tomography (PET-CT) imaging of ophthalmic patients with systemic sarcoidosis. METHODS:Four systemic sarcoidosis patients were evaluated with PET-CT for staging. Two had been treated for conjunctival melanoma a...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273940802596567
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:To describe the clinical and histopathological features of post viper bite anterior segment ischemia. METHODS:Seven patients with ocular complications following viper bite referred to uveitis clinic had slit-lamp examination, intraocular pressure (IOP) measurement, and fundus evaluation. Iris and fundus fluore...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.3109/09273948.2014.907435
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:To report a case of acute retinal necrosis (ARN) occurring in the opposite eye to the ophthalmic shingles eruption. DESIGN:Case report. METHODS:Clinical examination and multimodal imaging review, including ultra-widefield photography and fluorescein angiography (FA). RESULTS:A 49-years-old man attended the U...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2020.1770298
更新日期：2020-07-09 00:00:00
abstract：:Introduction: Uveitic macular edema (UME) is a significant cause of visual impairment in all uveitis types. Methods: Reports that were cited in the MEDLINE database, that analyzed the effectiveness of biologics for UME in at least five patients, with a minimum follow-up of 3 months, published prior to April 1, 2019 we...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.1080/09273948.2019.1709648
更新日期：2020-11-16 00:00:00
abstract：PURPOSE:To report a rare case of intermediate uveitis following rubella infection in pregnancy. DESIGN:Case report. METHODS:A 35-year-old pregnant woman, at 24 weeks of gestation, presented with sudden floaters and blurring of vision of the left eye. Ocular examination revealed vitritis 1-2+ with no retinal involveme...
journal_title：Ocular immunology and inflammation
pub_type： 杂志文章
doi：10.3109/09273948.2011.555593
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:To describe the results of Boston keratoprosthesis implantation in a patient with Stevens-Johnson syndrome following autologous submandibular gland transplantation. DESIGN:Observational case report. METHODS:We report the case of a man diagnosed with Stevens-Johnson syndrome. Autologous submandibular gland tra...
journal_title：Ocular immunology and inflammation
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