Preliminary Report on Interleukin-22, GM-CSF, and IL-17F in the Pathogenesis of Acute Anterior Uveitis.

Abstract:

:Purpose: Anterior uveitis is the most common anatomic subset of uveitis. We developed a novel multi-parametric flow cytometry panel to identify immune dysregulation signatures in HLA B27-associated acute anterior uveitis (AAU) and axial spondyloarthritis (AxSpA).Methods: We used fluorescence activated cell sorting to characterize T cell cytokine expression in stimulated T cell subsets from patients with AAU (n = 4) compared to healthy controls (n = 14) or subjects with AxSpA (n = 6).Results: Positive findings among subjects with AAU included a statistically significant increase in stimulated granulocyte-macrophage colony stimulating factor (GM-CSF), IL-17, and IL-22 synthesized by CD8 cells, a trend for stimulated ILC (innate lymphoid cells)-3 cells to synthesize more IL-22 (p = .07), and stimulated MAIT (mucosa associated innate lymphoid cells)-like cells that express the T cell receptor V alpha 7.2 to express IL-17A, IL-17F, and IL-22 in a greater percentage of cells relative to controls. IL-17F, GM- CSF, and IL-22 represent potentially novel targets in AAU.Conclusion: Our report is arguably the first to implicate IL-17F or ILC-3 and MAIT cells in the pathogenesis of AAU.Abbreviations AAU: acute anterior uveitis; AxSpA: axial spondyloarthritis; BASDAI: Bath ankylosing spondylitis disease activity index; CCR: chemokine receptor; DMSO: dimethylsulfoxide; EULAR:European League Against Rheumatism; FACS: fluorescence activated cell sorter; FBS: fetal bovine serum; FSC: orward light scatter; GM-CSF: granulocyte-macrophage colony stimulating factor; HC: healthy control; ILC: innate lymphoid cell; KIR: killer immunoglobulin receptor; MAIT: mucosal associated immune T cell; ND: not detected; NK: natural killer cell; OHSU-Oregon Health & Science University; PBMC: peripheral blood mononuclear cell; SSC: side light scatter; TCR: T cell receptor.

journal_name

Ocul Immunol Inflamm

authors

Huang JC,Schleisman M,Choi D,Mitchell C,Watson L,Asquith M,Rosenbaum JT

doi

10.1080/09273948.2019.1686156

subject

Has Abstract

pub_date

2019-11-25 00:00:00

pages

1-8

eissn

0927-3948

issn

1744-5078

pub_type

信件
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    abstract:PURPOSE:To report a case of acute retinal necrosis (ARN) occurring in the opposite eye to the ophthalmic shingles eruption. DESIGN:Case report. METHODS:Clinical examination and multimodal imaging review, including ultra-widefield photography and fluorescein angiography (FA). RESULTS:A 49-years-old man attended the U...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1770298

    authors: Battista M,Marchese A,Bordato A,Bandello F,Modorati GM,Miserocchi E

    更新日期:2020-07-09 00:00:00

  • Long-term Efficacy of Interferon in Severe Uveitis Associated with Behçet Disease.

    abstract:PURPOSE:To retrospectively assess the frequency of ocular relapse and the possibility of long-term remission in patients treated with interferon (IFN) for severe uveitis associated with Behçet disease. METHODS:All patients were treated with an initial dosage of 3 million IU IFN three times a week. The main outcome mea...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2016.1206204

    authors: Diwo E,Gueudry J,Saadoun D,Weschler B,LeHoang P,Bodaghi B

    更新日期:2017-02-01 00:00:00

  • Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract.

    abstract:PURPOSE:To compare levels of selected mediators in serums and aqueous humor (AH) of type 2 diabetes mellitus cataract patients with senile cataract patients, and to determine their association with postoperative corneal edema (CE). METHODS:Patients (32 senile and 29 diabetic cataract) undergoing standardized phacoemul...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.949779

    authors: Mitrović S,Kelava T,Šućur A,Grčević D

    更新日期:2016-01-01 00:00:00

  • Chronic Anterior Uveitis Associated with Relapsing Polychondritis: A Case Report.

    abstract::Purpose: To report a case of chronic anterior uveitis associated with relapsing polychondritis (RP).Case Report: A 43-year-old female patient presenting with bilateral progressive vision loss was diagnosed with bilateral anterior uveitis. According to her clinical signs and symptoms and biopsy results, RP was ultimate...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2018.1547834

    authors: Wei Y,Chi Y,Fang Y,Wu D,Qiao R

    更新日期:2020-01-01 00:00:00

  • Ocular Involvement in Muckle-Wells Syndrome.

    abstract::Purpose: To present the ocular findings of the members of a family that has the diagnosis of Muckle Wells syndrome, a form of cryopyrin associated periodic syndrome (CAPS).Materials and Methods: Nine patients with MWS were included in this study. Each study participant underwent a systemic evaluation, comprehensive op...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1552305

    authors: Cekic S,Yalcinbayir O,Kilic SS

    更新日期:2020-01-01 00:00:00

  • Subcutaneous Tocilizumab for Cystoid Macular Edema Secondary to Juvenile Idiopathic Arthritis (JIA)-associated Uveitis: A Case Report.

    abstract::Purpose: To report a case of cystoid macular edema (CME) secondary to juvenile idiopathic arthritis (JIA)-associated uveitis. Case report: 26-year-old female patient presented with CME in both eyes. CME became refractory and TCZ-IV was initiated. After 12 infusions was stopped because grade 1 neuropenia developed. On ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1644350

    authors: Adán A,Moll-Udina A,Ramirez J,Llorenç V

    更新日期:2019-10-07 00:00:00

  • Diagnostic value of specific local antibody production and nucleic acid amplification technique-nested polymerase chain reaction (nPCR) in clinically suspected ocular toxoplasmosis.

    abstract:OBJECTIVE:The study was to evaluate the diagnostic efficacy of nested polymerase chain reaction (nPCR) using primers targeting B1 gene of Toxoplasma gondii (T. gondii) with Witmer Desmonts coefficient (WDC) technique in intraocular fluids of clinically suspected toxoplasma retino choroiditis (TRC) patients. MATERIALS ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940500545692

    authors: Mahalakshmi B,Therese KL,Madhavan HN,Biswas J

    更新日期:2006-04-01 00:00:00

  • Treatment of severe ocular hypotony in AIDS patients with cytomegalovirus retinitis and cidofovir-associated uveitis.

    abstract:OBJECTIVE:To describe the medical treatment of severe ocular hypotony in HIV-seropositive patients with cytomegalovirus retinitis and cidofovir-associated uveitis. PATIENTS AND METHODS:Two HIV-seropositive patients with cytomegalovirus retinitis and cidofovir-associated uveitis complicated by severe ocular hypotony we...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.9.3.211.3968

    authors: Accorinti M,Ciapparoni V,Pirraglia MP,Pivetti-Pezzi P

    更新日期:2001-09-01 00:00:00

  • Corneal Graft Rejection after Yellow Fever Vaccine: A Case Report.

    abstract::Purpose: To report an unusual case of corneal graft rejection after yellow fever vaccine. Methods: Case report. Results: We have described the case of a 48-year-old man who developed a corneal graft rejection in the left eye 3 weeks after a yellow fever vaccination. The ophthalmic examination of the left eye revealed ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1870146

    authors: Vignapiano R,Vicchio L,Favuzza E,Cennamo M,Mencucci R

    更新日期:2021-01-28 00:00:00

  • Clinical study on patients with Behçet's disease in Hokkaido.

    abstract::Behçet's disease is the most frequently encountered form of endogenous uveitis in Japan. The authors examined the clinical manifestations in cases with Behçet's disease over six years (1987-1992), and compared the results with those of a previous study (1978-1983). In the more recent study the number of new patients w...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949509069117

    authors: Kotake S,Furudate N,Sasamoto Y,Yoshikawa K,Okamoto T,Goda C,Matsuda H

    更新日期:1995-01-01 00:00:00

  • The Effect of Androgens on Proinflammatory Cytokine Secretion from Human Ocular Surface Epithelial Cells.

    abstract::Purpose: The purpose of this study is to explore the effects of dihydrotestosterone (DHT) on lipopolysaccharide (LPS)-induced proinflammatory cytokine release in human ocular surface epithelial cells exposed to LPS and LPS-binding protein (LBP).Methods: Immortalized human corneal, conjunctival, and meibomian gland epi...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1686155

    authors: Marangoz D,Oner C,Schicht M,Turgut Cosan D,Paulsen F,Yildiz E,Zibandeh N,Sahin A

    更新日期:2019-11-18 00:00:00

  • Mucormycosis Endophthalmitis in a Silicone Oil-Filled Eye of an Immunocompetent Patient.

    abstract::Purpose:: Fungal endophthalmitis following pars plana vitrectomy with silicone oil tamponade is an infrequent entity. Filamentous fungi like aspergillus are generally associated with endophthalmitis. Mucor is a rarely implicated pathogen in cases of endophthalmitis with only two reported cases in medical literature. B...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2018.1518462

    authors: Dogra M,Bhutani G,Gupta V

    更新日期:2019-01-01 00:00:00

  • Subretinal fibrosis and uveitis syndrome in a patient with ectodermal dysplasia.

    abstract:PURPOSE:To report a case of subretinal fibrosis and uveitis syndrome in association with ectodermal dysplasia. METHODS:Chart review of a patient with subretinal fibrosis and uveitis syndrome and ectodermal dysplasia. RESULTS:The authors identified one case of a patient with the diagnoses of subretinal fibrosis and uv...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273940903168670

    authors: Huffman RI,Huang JJ

    更新日期:2009-09-01 00:00:00

  • Inflammatory Papillitis in Uveitis: Response to Treatment and Use of Optic Nerve Optical Coherence Tomography for Monitoring.

    abstract:PURPOSE:To describe the clinical course of uveitis-associated inflammatory papillitis and evaluate the utility and reproducibility of optic nerve spectral domain optical coherence tomography (SD-OCT). METHODS:Data on 22 eyes of 14 patients with uveitis-related papillitis and optic nerve imaging were reviewed. SD-OCT m...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.991041

    authors: Cho H,Pillai P,Nicholson L,Sobrin L

    更新日期:2016-01-01 00:00:00

  • Multimodal Imaging in Ocular Tuberculosis.

    abstract::Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1080/09273948.2016.1231332

    authors: Agarwal A,Mahajan S,Khairallah M,Mahendradas P,Gupta A,Gupta V

    更新日期:2017-02-01 00:00:00

  • Antigen-presenting cells are targets of regulatory T cells similar to those that mediate anterior chamber-associated immune deviation.

    abstract:PURPOSE:To identify the means by which in-vitro-generated regulatory T cells, similar to those in anterior chamber-associated immune deviation (ACAID), suppress antigen-specific T-cell responses. METHODS:T regulators (T regs), generated by stimulating ovalbumin (OVA)-specific Tcr transgenic DO11.10 T cells with OVA-pu...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940490895317

    authors: Yokoi H,Streilein JW

    更新日期:2004-06-01 00:00:00

  • Isolated Nocardia exalbida endogenous endophthalmitis.

    abstract:PURPOSE:To report an immunocompetent patient with Nocardia exalbida endogenous endophthalmitis. DESIGN:Case report. METHODS:Clinical-pathologic correlation and microbiologic evaluation were performed on an enucleated eye. RESULTS:A 56-year-old man presented with rapidly progressive vision loss associated with a post...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.3109/09273948.2011.563898

    authors: Milman T,Trubnik V,Shah M,McCormick SA,Finger PT

    更新日期:2011-08-01 00:00:00

  • Etiology and Clinical Features of Ocular Inflammatory Diseases in a Tertiary Referral Centre in Sydney, Australia.

    abstract:PURPOSE:To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS:The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2016.1247871

    authors: Zagora SL,Symes R,Yeung A,Yates W,Wakefield D,McCluskey PJ

    更新日期:2017-01-01 00:00:00

  • Regional Differences in the Clinical Manifestation of Ocular Toxoplasmosis Between the Center and Northeast of Argentina.

    abstract::Purpose: To compare the clinical characteristics of patients with active episodes of ocular toxoplasmosis from three provinces, Misiones, Santa Fe, and Buenos Aires, Argentina. Methods: Patients with a diagnosis of ocular toxoplasmosis from three databases of four tertiary referral uveitis centers were reviewed. Colle...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1484494

    authors: Schlaen A,Colombero D,Ormaechea S,Ladeveze E,Rudzinski C,Ingolotti M,Couto C,Rudzinski M

    更新日期:2019-01-01 00:00:00

  • Post-Streptococcal Uveitis: Case Report.

    abstract::Background: Post-streptococcal uveitis is a rare ocular disease which is part of other auto-immune conditions associated with post-streptococcal syndrome. It was first mentioned in medical literature in 1991, with only a few cases published at that time. We are presenting the case of a patient with bilateral panuveiti...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1501493

    authors: Medina CA,Fajardo A,Calderon A,Aracena M

    更新日期:2019-01-01 00:00:00

  • Ocular Manifestations of Human Immunodeficiency Virus Infection at a Tertiary Referral Center in Taiwan.

    abstract::Purpose: To investigate the prevalence and characteristics of ocular manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in patients treated at a tertiary referral center in Taiwan during a time of highly active antiretroviral therapy (HAART) Materials and Methods: A retrospect...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1499939

    authors: Tsen CL,Chen YS,Wu KS,Tsai HC,Chen YH,Lee YY,Sheu SJ

    更新日期:2019-01-01 00:00:00

  • Macular Abnormalities in Vogt-Koyanagi-Harada Disease.

    abstract::Purpose: To investigate the prevalence of macular abnormalities in Chinese Vogt-Koyanagi-Harada (VKH) patients.Methods: Clinical characteristics, therapeutic effectiveness and visual outcome were reviewed and analyzed.Results: The most common macular abnormality was macular edema (ME), followed by macular choroidal ne...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1624781

    authors: Yang P,Ye Z,Xu J,Du L,Zhou Q,Qi J,Liang L,Wang C,Zhou C,Cao Q,Wu L,Kijlstra A

    更新日期:2019-01-01 00:00:00

  • Tear secretory IgA: evaluation of usefulness as a diagnostic marker in herpetic keratitis.

    abstract::In a South Indian study, an 'in-house' enzyme-linked immunosorbent assay (ELISA) was developed to evaluate the potential of herpes simplex virus (HSV)-specific tear secretory IgA (sIgA) in the diagnosis of herpes simplex keratitis (HSK). The presence of HSV-specific tear sIgA was found to be diagnostic in 20.28% of ca...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.7.2.61.4023

    authors: Pramod NP,Dhevahi E,Sudhamathi K,Kannan K,Thyagarajan SP

    更新日期:1999-06-01 00:00:00

  • Clinical Course and Outcomes of Pediatric Tubercular Uveitis in North India.

    abstract:PURPOSE:To analyze the clinical features, course, management, and outcomes of tubercular (TB) uveitis in the pediatric population and assess the response to anti-tubercular therapy (ATT). METHODS:Hospital records of children (≤16 years) from a large tertiary-care institute between January 2001 and December 2015 were r...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1296579

    authors: Kaur S,Aggarwal K,Agarwal A,Suri D,Gupta A,Singh R,Bansal R,Singh S,Singh N,Gupta A,Gupta V

    更新日期:2018-01-01 00:00:00

  • Retinal Pigment Epithelium Tear after Immunosuppressive Treatment for Sarcoidosis-related Choroidal Granuloma.

    abstract:PURPOSE:To describe the formation of a retinal pigment epithelial (RPE) tear following immunosuppressive treatment of a large choroidal granuloma in a patient with sarcoidosis-related panuveitis. METHODS:A 25-year-old woman presented with bilateral sarcoidosis-related panuveitis and optic disc edema in both eyes with ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2016.1180402

    authors: Knickelbein JE,Wei M,Nussenblatt RB,Sen HN

    更新日期:2017-12-01 00:00:00

  • Impact of Inflammation and Treatment on Self-reported Quality of Life in Patients with Non-acute Vogt-Koyanagi-Harada Disease (VKHD).

    abstract::Aims: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients.Methods: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for ≥12 months since acute dise...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1668431

    authors: Souto FMS,Missaka RFBG,Magalhães BM,Caetano VMC,Takiuti JT,Lavezzo MM,Sakata VM,Oyamada MK,Hirata CE,Yamamoto JH

    更新日期:2019-10-31 00:00:00

  • Bacterial contamination of needles used for intravitreal injections: comparison between 27-gauge and 30-gauge needles.

    abstract:PURPOSE:To compare the contamination rate between 27-gauge and 30-guage needles used for intravitreal injection (IVT). METHODS:Patients undergoing IVT injections were enrolled prospectively. Injections were performed with 27- or 30-gauge needles. All needle tips were collected and placed in brain-heart infusion broth....

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2013.801988

    authors: Tufan HA,Vural A,Gencer B,Kara S,Arikan S,Yuksel E

    更新日期:2013-10-01 00:00:00

  • Endophthalmitis in HIV Infection.

    abstract::Purpose: The role of HIV infection in exogenous and endogenous endophthalmitis has not been clarified. We aim to assess the potential role of HIV as a risk factor or a poor prognostic feature in this sight-threatening condition. Methods: Literature review. Review of evidence: Evidence for endophthalmitis in HIV patien...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1699580

    authors: Tsirouki T,Steffen J,Dastiridou A,Praidou A,Androudi S

    更新日期:2020-10-02 00:00:00

  • Clinical Follow-up of Patients with Behçet Uveitis after Discontinuation of Infliximab Therapy.

    abstract:PURPOSE:To evaluate the clinical course of patients with Behçet uveitis after discontinuation of infliximab (IFX) therapy. METHODS:Medical records of eight patients who discontinued treatment between 2010 and 2018 were retrospectively analyzed. The main outcome measures were frequency of uveitis attacks per year, best...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1774907

    authors: Köse HC,Yalçındağ N

    更新日期:2020-08-11 00:00:00

  • Anterior scleritis, scleral thinning, and intraocular pressure measurement.

    abstract::We report a case of unilateral glaucoma with falsely low intraocular pressure reading as a result of scleral thinning from anterior scleritis. ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940490912344

    authors: Nessim M,Kyprianou I,Kumar V,Murray PI

    更新日期:2005-12-01 00:00:00