Comparison of the acute effects of anti-TNF-alpha drugs on a uveitis experimental model.

Abstract:

PURPOSE:To compare histopathological and biochemical effects of the anti-TNF-alpha drugs adalimumab and infliximab in a uveitis experimental model. METHODS:Histopathological evaluation was performed 24 h after endotoxin (200 microg into the footpad) and drug administration, as well as biochemical analysis of oxidative stress-related markers in the aqueous humor. RESULTS:Severe inflammation was found in rat anterior chamber of the eye 24 h after endotoxin. Only infliximab administration partially prevented the endotoxin-induced disruption of the blood-aqueous barrier, as well as the increase in Rantes and MCP-1 concentration in aqueous humor. Both drugs ameliorated the histopathological score after endotoxin. Biochemical analysis revealed that both drugs protected against endotoxin-induced oxidative stress, restoring all markers to control levels, except infliximab, which failed to restore GSH concentration. CONCLUSIONS:Both anti-TNF-alpha drugs were effective in reducing histopathological inflammation but their mechanism of action appears to be different.

journal_name

Ocul Immunol Inflamm

authors

Johnsen-Soriano S,Sancho-Tello M,Arnal E,Díaz-Llopis M,Navea A,Miranda M,Bosch-Morell F,Romero FJ

doi

10.3109/09273940903521964

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

208-15

issue

3

eissn

0927-3948

issn

1744-5078

journal_volume

18

pub_type

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