Ipilimumab-induced Ocular and Orbital Inflammation--A Case Series and Review of the Literature.

Abstract:

PURPOSE:Ipilimumab, a monoclonal antibody directed against the immune protein cytotoxic T-lymphocyte antigen-4 (CTLA-4), characteristically induces side effects called "immune-related adverse events" (IRAE). Although ophthalmic involvement is rare, we report 7 cases of eye and orbit complications related to ipilimumab therapy. METHODS:We performed a retrospective review of patients with metastatic melanoma who developed ipilimumab-related ocular or orbital inflammation who were seen at our institutions. RESULTS:Seven patients were identified: 4 patients had orbital inflammation, 2 had uveitis, and 1 had peripheral ulcerative keratitis. Four patients developed inflammation after the second ipilimumab infusion, 2 after the third infusion and 1 after the first infusion. All 4 patients with orbital inflammation were treated with systemic corticosteroids. Two patients with uveitis were treated with topical steroids, but were also treated with systemic corticosteroids for other IRAE, including colitis and hypophysitis. The patient with keratitis was treated with topical corticosteroids alone with resolution of inflammation. All 7 patients discontinued ipilimumab therapy, 5 due to systemic IRAE and 2 due to tumor progression. Five of 7 patients had tumor progression on ipilimumab therapy. CONCLUSIONS:Ocular and orbital inflammation may occur in patients with metastatic melanoma receiving ipilimumab, is frequently accompanied by other IRAEs, and resolves with corticosteroid treatment, often leaving no long-term sequelae.

journal_name

Ocul Immunol Inflamm

authors

Papavasileiou E,Prasad S,Freitag SK,Sobrin L,Lobo AM

doi

10.3109/09273948.2014.1001858

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

140-6

issue

2

eissn

0927-3948

issn

1744-5078

journal_volume

24

pub_type

杂志文章,评审
  • Clinical profile, treatment, and visual outcome of ampiginous choroiditis.

    abstract:PURPOSE:To report the clinical profile and management of patients diagnosed to have ampiginous choroiditis in a tertiary care referral centre in India. METHODS:Retrospective cohort study. Twenty-six eyes of 16 patients were included in the study, which was diagnosed as choroiditis, serpiginous choroiditis, and acute p...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273940903402637

    authors: Jyotirmay B,Jafferji SS,Sudharshan S,Kalpana B

    更新日期:2010-01-01 00:00:00

  • Multimodal Imaging in Ocular Sarcoidosis.

    abstract::Aim: Ocular sarcoidosis presents a diagnostic challenge because of its varied clinical presentations. It is important to distinguish sarcoidosis from other uveitis diseases. Multimodal imaging provides useful data to be introduced into clinical practice. Methods: This is a review article. Conclusions: This review arti...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1751210

    authors: Mahendradas P,Maruyama K,Mizuuchi K,Kawali A,Kitaichi N

    更新日期:2020-11-16 00:00:00

  • Features of Retinitis-like Lesions in Vitreoretinal Lymphoma.

    abstract::Purpose: To describe the distinguishing features of retinitis-like lesions seen in vitreoretinal lymphoma (VRL) from viral and toxoplasma retinitis. Methods: In this multicenter, retrospective study, we reviewed charts and imaging of consecutive patients with VRL. The associated features and the characteristics of ret...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1648835

    authors: Marchese A,Agarwal A,Miserocchi E,Giuffrè C,Bandello F,Modorati G,Prakash G,Gupta N,Bosello F,Sharma SP,Gupta V

    更新日期:2019-09-30 00:00:00

  • Indocyanine green and fundus fluorescein angiographic findings in patients with active ocular Behcet's disease.

    abstract:PURPOSE:To define the indocyanine green (ICG) and fundus fluorescein angiographic (FFA) features of Behçet's disease. METHODS:The study included 49 eyes of 25 patients (19 males, 6 females; mean age: 34.1 years; age range: 14-68 years) with Behçet's disease and active ocular involvement that fulfilled the criteria of ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940490518757

    authors: Gedik S,Akova Y,Yilmaz G,Bozbeyoğlu S

    更新日期:2005-02-01 00:00:00

  • Optic Nerve Infiltration in Systemic Metastatic Retinal Lymphoma (SMRL): Multimodal Imaging and Challenges in Diagnosis.

    abstract::A 45-year-old man was diagnosed with diffuse large B-cell lymphoma stage IV which was confirmed by celiac lymph node biopsy. He subsequently completed six cycles of R-CHOP chemotherapy. Six months later, he presented with panuveitis OU with positive relative afferent pupillary defect OD. OCT revealed hyper-reflective ...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2020.1800050

    authors: Mohd Fauzi Yap MFB,Mohd Zain A,Tumain NR,Palaniappan S,Nasaruddin RA,Md Din N

    更新日期:2020-09-24 00:00:00

  • Epidemic Retinitis with Macular Edema -Treatment Outcome with and without Steroids.

    abstract::Purpose: To study treatment outcomes with and without oral corticosteroids in epidemic retinitis (ER).Method: A retrospective, observational study of 35 eyes of 29 patients diagnosed as ER. Days taken for resolution of macular edema and retinitis lesions were compared in patients treated with oral antibiotics (Group 1...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1704792

    authors: Kawali A,Srinivasan S,Mohan A,Bavaharan B,Mahendradas P,Shetty B

    更新日期:2020-01-21 00:00:00

  • Post-streptococcal vasculitis.

    abstract:PURPOSE:To report a case of post-streptococcal retinal vasculitis. DESIGN:Review of a case. METHODS:Review of patient chart and fluorescein angiography. RESULTS:A 17 year old African American female presented with moderate vitritis and macular edema in the right eye and retinal vessel sheathing in both eyes. CONCLU...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940701799163

    authors: Reddy UP,Albini TA,Banta JT,Davis JL

    更新日期:2008-01-01 00:00:00

  • Collagen Cross-Linking in the Management of Microbial Keratitis.

    abstract::Increasing resistance to antimicrobial agents has contributed to an elevated risk of complications of infectious keratitis. Corneal collagen cross-linking (CXL) has been widely adopted for the management of keratoconus and post-refractive surgery corneal ectasia. It has recently been introduced as an option for treati...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1080/09273948.2017.1414856

    authors: Bonzano C,Di Zazzo A,Barabino S,Coco G,Traverso CE

    更新日期:2019-01-01 00:00:00

  • Evaluation of the Anterior Segment Parameters of the Patients with Scleroderma.

    abstract:PURPOSE:To evaluate corneal parameters of scleroderma (SC) patients by Pentacam-HR. METHODS:Twenty-two eyes of 22 SC patients and 33 eyes of 33 control subjects were enrolled. All participants underwent Pentacam (Pentacam-HR, Oculus, Germany) evaluation. Both SC and control groups were divided into two subgroups as dr...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2015.1115079

    authors: Şahin M,Yüksel H,Şahin A,Cingü AK,Türkcü FM,Kaya S,Yazmalar L,Batmaz İ

    更新日期:2017-04-01 00:00:00

  • Serpiginous choroiditis in a referral clinic in India: visual field changes and clinical correlates.

    abstract:PURPOSE:To report the visual field changes in patients with serpiginous choroiditis as seen in a referral clinic in India. METHODS:A retrospective noncomparative case series was conducted. Twenty-nine eyes of 17 patients who were diagnosed with serpiginous choroiditis were included in the study. Clinical findings were...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.902473

    authors: Balarabe AH,Biswas J

    更新日期:2014-10-01 00:00:00

  • Efficacy and Safety of Corticosteroid Implants in Non-infectious Uveitis: A Systematic Review with Network Meta-analysis.

    abstract:BACKGROUND/AIMS:To compare different existent implants for noninfectious uveitis. METHODS:We performed a systematic review of randomized clinical trials (RCTs), searching in five electronic databases and screening reference lists of included studies and relevant reviews. We performed network meta-analysis to compare 0...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1787463

    authors: Vieira R,Sousa-Pinto B,Figueira L

    更新日期:2020-08-18 00:00:00

  • Atypical presentation of multiple evanescent white dot syndrome (MEWDS).

    abstract:PURPOSE:To present fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and microperimetry (MP) findings of a patient with multiple evanescent white dot syndrome (MEWDS). METHODS:Observational case report. RESULTS:A 30-year-old woman with blurry vision was referred for evaluation. Fundus examination r...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940802026060

    authors: Yenerel NM,Kucumen B,Gorgun E,Dinc UA

    更新日期:2008-05-01 00:00:00

  • Corneal Graft Rejection after Yellow Fever Vaccine: A Case Report.

    abstract::Purpose: To report an unusual case of corneal graft rejection after yellow fever vaccine. Methods: Case report. Results: We have described the case of a 48-year-old man who developed a corneal graft rejection in the left eye 3 weeks after a yellow fever vaccination. The ophthalmic examination of the left eye revealed ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1870146

    authors: Vignapiano R,Vicchio L,Favuzza E,Cennamo M,Mencucci R

    更新日期:2021-01-28 00:00:00

  • Antigen-presenting cells are targets of regulatory T cells similar to those that mediate anterior chamber-associated immune deviation.

    abstract:PURPOSE:To identify the means by which in-vitro-generated regulatory T cells, similar to those in anterior chamber-associated immune deviation (ACAID), suppress antigen-specific T-cell responses. METHODS:T regulators (T regs), generated by stimulating ovalbumin (OVA)-specific Tcr transgenic DO11.10 T cells with OVA-pu...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940490895317

    authors: Yokoi H,Streilein JW

    更新日期:2004-06-01 00:00:00

  • A Focus on the Epidemiology of Uveitis.

    abstract:PURPOSE:Uveitis is a common, sight-threatening inflammatory ocular disease and includes multiple heterogeneous clinical entities. The prevalence of various types of uveitis depends upon multiple factors, such as age, sex, race, geographic distribution, environmental influence, genetics, and social habits. Epidemiologic...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1080/09273948.2016.1196713

    authors: Tsirouki T,Dastiridou A,Symeonidis C,Tounakaki O,Brazitikou I,Kalogeropoulos C,Androudi S

    更新日期:2018-01-01 00:00:00

  • Drug therapy in Behçet's disease.

    abstract::Behçet's disease is one of the most difficult forms of uveitis to treat. Variety in disease presentation and severity, as well as regional differences in standard of care, demand a tailor-made approach. Anterior segment inflammation generally responds to topical corticosteroids. However, the onset of posterior segment...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:

    authors: Okada AA

    更新日期:2000-06-01 00:00:00

  • Neuro-Behcet Disease and Ocular Inflammation: A Case Report and Literature Review.

    abstract::Purpose: To describe a case of panuveitis with occlusive vasculitis leading to the diagnosis of neuro-Behcet disease (NBD) and discuss the relationship between uveitis and NBD. Methods: Case report with a literature review of ocular inflammation in NBD. Results: A 26-year-old woman with a seven-month history of recurr...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1787461

    authors: Patel SA,Okeagu C,Jones K,Chaudhry A,Berkenstock MK

    更新日期:2020-08-19 00:00:00

  • The spectrum of ocular involvement in systemic lupus erythematosus in a tertiary eye care center in Nepal.

    abstract:PURPOSE:Manifestations of Systemic lupus erythematosus are protean and the eye can get affected in more than a third of the cases. This study was conducted to evaluate the spectrum of ocular manifestation among Nepalese patients diagnosed with Systemic lupus erythematosus. METHODS:In this hospital based cross-sectiona...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2011.610023

    authors: Sitaula R,Shah DN,Singh D

    更新日期:2011-12-01 00:00:00

  • Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) - Report 2: Pattern of Uveitis Investigations in Singapore.

    abstract::Purpose: To analyze the pattern of laboratory investigations of uveitis at a tertiary referral eye care center in Singapore.Methods: Retrospective analysis of 2040 uveitis cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database over a 12-year period (2004 - 2015).Results: Patients with...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1535080

    authors: Low R,Chen EJ,Bin Ismail MA,Mi H,Ling HS,Lim WK,Teoh SC,Agrawal R

    更新日期:2020-01-01 00:00:00

  • Dark spot in fibrinous central serous chorioretinopathy masquerading choroiditis.

    abstract:PURPOSE:The authors observed that eyes with acute fibrinous central serous chorioretinopathy (CSC) masquerading active choroiditis had a "dark spot" within the yellow fibrinous deposit. The present study aims to describe this sign as a clinical indicator of acute serofibrinous exudative detachment, thus helping to diff...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2013.765015

    authors: Parchand S,Gupta V,Gupta A,Dogra MR,Singh R,Sharma A

    更新日期:2013-06-01 00:00:00

  • Diagnostic Utility of Quantitative Polymerase Chain Reaction versus Culture in Endophthalmitis and Uveitis.

    abstract::Purpose: To compare genetic testing for microbes in infectious endophthalmitis or uveitis to culture.Methods: This was a retrospective, single-center case series that enrolled patients with clinically suspected endophthalmitis or uveitis of unknown etiology. Aqueous humor or vitreous was collected and sent for routine...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1431291

    authors: Sandhu HS,Hajrasouliha A,Kaplan HJ,Wang W

    更新日期:2019-01-01 00:00:00

  • Isolated Nocardia exalbida endogenous endophthalmitis.

    abstract:PURPOSE:To report an immunocompetent patient with Nocardia exalbida endogenous endophthalmitis. DESIGN:Case report. METHODS:Clinical-pathologic correlation and microbiologic evaluation were performed on an enucleated eye. RESULTS:A 56-year-old man presented with rapidly progressive vision loss associated with a post...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.3109/09273948.2011.563898

    authors: Milman T,Trubnik V,Shah M,McCormick SA,Finger PT

    更新日期:2011-08-01 00:00:00

  • Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients.

    abstract::Objective: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin. Material and Methods: Multicenter retrospective study of 38 patients with at least one test, either HCMV-posit...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1662059

    authors: Leleu I,Jhanji V,Touhami S,Westcott M,Angi M,Titah C,Rousseau A,Hamard P,Brasnu E,Manicom T,Blumen-Ohana E,Rozenberg F,Vauloup-Fellous C,Deback C,Labetoulle M,Sahel JA,Bodaghi B,Merabet L,Kobal A,Brignole-Baudouin F

    更新日期:2019-10-23 00:00:00

  • Evolving "Diagnostic" Criteria for Axial Spondyloarthritis in the Context of Anterior Uveitis.

    abstract::Anterior uveitis is far more common than intermediate, posterior or panuveitis. About 50% of patients with acute anterior uveitis are HLA B27+. Those who are HLA B27+ are highly likely to have associated back, joint, or tendon disease. The majority of patients with acute anterior uveitis and inflammatory low back pain...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.3109/09273948.2016.1158277

    authors: Rosenbaum JT

    更新日期:2016-08-01 00:00:00

  • Diagnostic Challenges in Inflammatory Choroidal Neovascular Membranes.

    abstract:PURPOSE:To describe the clinical presentations of inflammatory choroidal neovascular membranes (CNVMs) and factors leading to their delayed diagnosis. METHODS:Retrospective analysis of chart records and digital images of 60 patients (73 eyes) with inflammatory CNVM (January 1998 to December 2013) to obtain demographic...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2016.1160128

    authors: Bansal R,Bansal P,Gupta A,Gupta V,Dogra MR,Singh R,Katoch D

    更新日期:2017-08-01 00:00:00

  • Intravitreal Ranibizumab for the Treatment of Irvine-Gass Syndrome.

    abstract:PURPOSE:The purpose of our study was to evaluate the potential efficacy and safety of intravitreal ranibizumab in patients with pseudophakic cystoid macular edema (CME). METHODS:This retrospective study comprised 7 eyes with CME treated with intravitreal ranibizumab. Patients were examined at 1 week and 1 month after ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.898775

    authors: Mitropoulos PG,Chatziralli IP,Peponis VG,Drakos E,Parikakis EA

    更新日期:2015-06-01 00:00:00

  • Use of PCR in endophthalmitis.

    abstract::In eyes with suspected endophthalmitis, early diagnosis and appropriate treatment have been noted to be associated with a better visual outcome. Currently, however, confirmation of the diagnosis of endophthalmitis (bacterial and/or fungal) is dependent on conventional techniques of microbiological isolation of organis...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:

    authors: Okhravi N,Adamson P,Lightman S

    更新日期:2000-09-01 00:00:00

  • Ocular Whipple Disease: Report of Three Cases.

    abstract::Purpose: To emphasize the different manifestations of ocular involvement in Whipple disease with challenge in establishing the diagnosis as clinical, laboratory, and histological features could mimic other uveitis entities. Methods: Case reports of three patients. Results: The first patient was an African male sufferi...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2018.1518461

    authors: Testi I,Tognon MS,Gupta V

    更新日期:2019-01-01 00:00:00

  • Post-Streptococcal Uveitis: Case Report.

    abstract::Background: Post-streptococcal uveitis is a rare ocular disease which is part of other auto-immune conditions associated with post-streptococcal syndrome. It was first mentioned in medical literature in 1991, with only a few cases published at that time. We are presenting the case of a patient with bilateral panuveiti...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1501493

    authors: Medina CA,Fajardo A,Calderon A,Aracena M

    更新日期:2019-01-01 00:00:00

  • Sterile endophthalmitis following intravitreal injection of triamcinolone acetonide.

    abstract:PURPOSE:To investigate clinical findings and ocular characteristics of sterile endophthalmitis following intravitreal injection (IVI) of triamcinolone for the treatment of macular edema. METHODS:IVI is an institutional practice at our hospital. From March 2002 to January 2003, a total of 21 IVIs of triamcinolone aceto...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940590951007

    authors: Wang LC,Yang CM

    更新日期:2005-07-01 00:00:00