Abstract:
PURPOSE:Longitudinal evaluation of acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) following diagnosis and treatment of metastatic melanoma. METHODS:Case report of a 47-year-old male with unknown primary metastatic melanoma and AEPPVM monitored before and during melanoma treatment using clinical exam, retinal imaging, and electroretinograms (ERG). Genetic testing and autoantibody panels were performed. RESULTS:He presented within a month of metastatic melanoma diagnosis with numerous bilateral vitelliform lesions in the posterior pole, consistent with AEPPVM. Metastatic disease was treated with immunotherapy, radiosurgery, and radiation over 48 months. Maculopathy and metastatic disease improved and worsened in parallel. Genetic testing was negative for bestrophin-1. An autoantibody panel was positive for anti-recoverin and transducin-α. CONCLUSION:AEPPVM is an uncommon paraneoplastic retinopathy found in patients with metastatic malignancy. To our knowledge, this is the first report demonstrating a temporal association between metastatic disease activity and quantifiable changes in retinal imaging over a 4-year period.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Mueller CM,Hojjatie SL,Lawson DH,Jain N,Robinson J,Khan MK,Yushak ML,O'Keefe GADdoi
10.1080/09273948.2020.1813782subject
Has Abstractpub_date
2020-10-06 00:00:00pages
1-8eissn
0927-3948issn
1744-5078pub_type
杂志文章abstract:PURPOSE:Primary vitreoretinal lymphomas (PVRL) pose a major diagnostic challenge, especially in the countries with a high prevalence of infectious variety of uveitis. The present study aims to report the clinical characteristics and diagnostic difficulties in patients with PVRL in an Indian Population. METHODS:Retrosp...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2016.1139731
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To evaluate corneal parameters of scleroderma (SC) patients by Pentacam-HR. METHODS:Twenty-two eyes of 22 SC patients and 33 eyes of 33 control subjects were enrolled. All participants underwent Pentacam (Pentacam-HR, Oculus, Germany) evaluation. Both SC and control groups were divided into two subgroups as dr...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1115079
更新日期:2017-04-01 00:00:00
abstract::Several subjective and arbitrary grading methods are used in assessing cell and flare in uveitis. Clinicians are in need of an objective method of determining and monitoring active inflammation. We studied the correlation of changes in macular thickness between the visits and compared the change to visual acuity (VA),...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802702587
更新日期:2009-07-01 00:00:00
abstract::Purpose: To report a case of chronic anterior uveitis associated with relapsing polychondritis (RP).Case Report: A 43-year-old female patient presenting with bilateral progressive vision loss was diagnosed with bilateral anterior uveitis. According to her clinical signs and symptoms and biopsy results, RP was ultimate...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2018.1547834
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To determine the incidence of bacterial contamination of needles used for intravitreal injections. METHODS:Patients undergoing intravitreal injections were enrolled prospectively. No pre-injection antibiotics were administered. Following povidone-iodine irrigation, conjunctival cultures were taken and the inje...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,多中心研究
doi:10.3109/09273948.2010.520405
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To define the indocyanine green (ICG) and fundus fluorescein angiographic (FFA) features of Behçet's disease. METHODS:The study included 49 eyes of 25 patients (19 males, 6 females; mean age: 34.1 years; age range: 14-68 years) with Behçet's disease and active ocular involvement that fulfilled the criteria of ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940490518757
更新日期:2005-02-01 00:00:00
abstract:PURPOSE:To describe four cases of familial Juvenile Idiopathic Arthritis (JIA) associated uveitis. DESIGN:Retrospective observational case series. METHODS:Clinical data from patients who present familial JIA-associated uveitis are described and possible genetic influence in disease etiology is reviewed. RESULTS:Two ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273941003678837
更新日期:2010-06-01 00:00:00
abstract::Purpose: Anterior uveitis is the most common anatomic subset of uveitis. We developed a novel multi-parametric flow cytometry panel to identify immune dysregulation signatures in HLA B27-associated acute anterior uveitis (AAU) and axial spondyloarthritis (AxSpA).Methods: We used fluorescence activated cell sorting to ...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2019.1686156
更新日期:2019-11-25 00:00:00
abstract::We report a case of unilateral glaucoma with falsely low intraocular pressure reading as a result of scleral thinning from anterior scleritis. ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940490912344
更新日期:2005-12-01 00:00:00
abstract::Purpose : To clarify whether a true neuroretinitis is part of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome.Methods : Critical literature review.Results : Neuroretinitis has been considered as a prominent feature of IRVAN syndrome. It has been described as late diffuse optic disc stai...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1836234
更新日期:2020-12-17 00:00:00
abstract:PURPOSE:To determine factors conferring an increased risk of developing ocular hypertension secondary to the fluocinolone acetonide (FA) sustained-release surgical implant (Retisert). DESIGN:Retrospective, observational case series. METHODS:Patients with a history of chronic noninfectious posterior uveitis undergoing...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1624778
更新日期:2020-07-03 00:00:00
abstract::Aim: To analyze the incidence, microbiological profile, risk factors, and outcomes in eyes with osteo-odonto keratoprosthesis (OOKP) developing endophthalmitis. Methods & material: Retrospective review of medical records of patients presenting between 2003 and 2013 with OOKP and endophthalmitis was undertaken after ob...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770807
更新日期:2020-10-07 00:00:00
abstract:PURPOSE:To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS:The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1247871
更新日期:2017-01-01 00:00:00
abstract::Purpose: To study treatment outcomes with and without oral corticosteroids in epidemic retinitis (ER).Method: A retrospective, observational study of 35 eyes of 29 patients diagnosed as ER. Days taken for resolution of macular edema and retinitis lesions were compared in patients treated with oral antibiotics (Group 1...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1704792
更新日期:2020-01-21 00:00:00
abstract:PURPOSE:To describe treatment practices for ocular toxoplasmosis among members of the Brazilian Uveitis Society. METHODS:An online questionnaire sent to specialists, between October 2014 and March 2015. RESULTS:Most respondents (67.9%) treat all active cases. Most specialists consider visual acuity <20/200 (88.2%), s...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1215471
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To evaluate the 10-year drug retention rate of infliximab (IFX) in Behçet's disease (BD)-related uveitis, the effect of a concomitant use of disease modifying anti-rheumatic drugs (DMARDs) on drug survival and differences according to the lines of biologic treatment. METHODS:Cumulative survival rates were stud...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1391297
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To compare Behçet uveitis patients who presented in the 1990s and 2000s. METHODS:Records of 170 patients seen in 1990-1994 and 258 patients seen in 2000-2004 were reviewed. Presenting features were analyzed in the whole cohort. Uveitis attacks, vision, complications, and immunomodulatory treatment (IMT) were c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2012.713159
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To investigate the incidence and risk factors of secondary glaucoma among uveitis patients. METHODS:Retrospective review of medical records of 642 patients (1220 eyes). RESULTS:Glaucoma was diagnosed in 169 (13.9%) eyes and was most common in eyes with anterior uveitis (19.1%) (p < 0.001). HLA-B27-positive an...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1047036
更新日期:2016-10-01 00:00:00
abstract::Background Uveal effusion is a rare disease that is characterized by exudative detachment of the ciliary body and choroid. Herein, we report a rare case of uveal effusion associated with viral encephalitis, which resolved following the treatment of the viral encephalitis and administration of corticosteroids. Case pre...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1797110
更新日期:2020-08-20 00:00:00
abstract:PURPOSE:To analyze the diagnostic predictive ability of clinical variables. METHODS:Demographic and clinical variables of 172 serologically proven leptospiral uveitis patients were compared with 200 controls of non-leptospiral uveitis. Multiple logistic regression analysis identified diagnostic predictors. A receiver ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1217341
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To investigate the safety of pharmaceutically compounded syringes for intravitreal administration of anti-vascular endothelial growth factor (anti-VEGF) drugs. METHODS:Single center, retrospective chart review. From 2015 to 2019, Oslo University Hospital, Norway gradually implemented pharmaceutical compounding...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1820530
更新日期:2020-10-07 00:00:00
abstract:PURPOSE:To present fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and microperimetry (MP) findings of a patient with multiple evanescent white dot syndrome (MEWDS). METHODS:Observational case report. RESULTS:A 30-year-old woman with blurry vision was referred for evaluation. Fundus examination r...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802026060
更新日期:2008-05-01 00:00:00
abstract::The treatment of articular and extra-articular manifestations associated with HLA-B27 has undergone dramatic changes over the past two decades, mainly as a consequence of the introduction of biologic agents and in particular anti-tumor necrosis factor α (anti-TNFα) agents. Uveitis is known to be the most frequent extr...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2016.1234625
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To describe the clinical course of uveitis-associated inflammatory papillitis and evaluate the utility and reproducibility of optic nerve spectral domain optical coherence tomography (SD-OCT). METHODS:Data on 22 eyes of 14 patients with uveitis-related papillitis and optic nerve imaging were reviewed. SD-OCT m...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.991041
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:To describe ocular findings in Turkish patients with Fuchs' uveitis (FU). METHODS:The medical records of FU were retrospectively reviewed. RESULTS:The study included 281 eyes of 258 patients with FU. There were diffusely spread keratic precipitates (KPs)[(medium sized in 253 (90.0%) eyes, stellate-medium i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1795207
更新日期:2020-08-24 00:00:00
abstract:PURPOSE:To analyze the retinal findings in patients with ARN, optical coherence tomography (OCT) was performed. METHODS:Seven patients (7 eyes) with ARN were studied using OCT. RESULTS:OCT images depicted highly reflective areas in the inner layers of the retina in all seven cases, corresponding with the yellowish-wh...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940600672198
更新日期:2006-06-01 00:00:00
abstract:AIMS/BACKGROUND:To assess the outcome and complications of cataract extraction in patients with Behçet's disease. METHODS:Thirty-six Behçet's disease patients underwent cataract surgery without intraocular lens implantation. Twenty-six patients had phacoemulsification or extracapsular cataract extraction, and ten pati...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949709085047
更新日期:1997-03-01 00:00:00
abstract::Purpose: To study outcome of secondary glaucoma in pediatric uveitis patients. Methods: Retrospective analysis of records of uveitis patients ≤16 years. Results: Of 182 pediatric uveitis patients, secondary glaucoma was seen in 48 patients (75 eyes, 26.23%) with female preponderance (F:M-29:19) . JIA was the most comm...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1411517
更新日期:2019-01-01 00:00:00
abstract:AIM:To look at markers to differentiate ocular sarcoidosis from ocular tuberculosis in a high TB endemic population. MATERIALS & METHODS:Retrospective multicenter study involving seven tertiary eyecare centers in India between July 2016 to December 2016. Demographic, clinical and laboratory data were retrieved from re...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1778733
更新日期:2020-09-01 00:00:00
abstract::Purpose: The purpose of the article is to describe a novel case of idiopathic central nervous system inflammatory disease with bilateral human leukocyte antigen (HLA)-B27-positive anterior uveitis. Methods/Results: A 15-year-old African American boy with bilateral HLA-B27-positive anterior uveitis controlled with topi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1449865
更新日期:2019-01-01 00:00:00