Abstract:
:Purpose: To investigate the prevalence of macular abnormalities in Chinese Vogt-Koyanagi-Harada (VKH) patients.Methods: Clinical characteristics, therapeutic effectiveness and visual outcome were reviewed and analyzed.Results: The most common macular abnormality was macular edema (ME), followed by macular choroidal neovascularization (CNV). Macular abnormalities were associated with recurrent episodes, disease course and visual acuity ≤20/50 at first visit. The prevalence of macular abnormalities in patients who were not treated according to our regular treatment regimen with corticosteroids combined with immunosuppressive agents and who were followed-up for at least one year (13.1%) was significantly higher than in patients receiving the regular treatment (5.7%). Visual improvement was found in 66.7% of eyes with macular abnormalities after regular treatment.Conclusion: Macular abnormalities were associated with recurrent uveitis, course of disease and lower visual acuity at first visit. Regular treatment could prevent the development of macular abnormalities and improved visual outcome in most patients.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Yang P,Ye Z,Xu J,Du L,Zhou Q,Qi J,Liang L,Wang C,Zhou C,Cao Q,Wu L,Kijlstra Adoi
10.1080/09273948.2019.1624781subject
Has Abstractpub_date
2019-01-01 00:00:00pages
1195-1202issue
8eissn
0927-3948issn
1744-5078journal_volume
27pub_type
杂志文章abstract:PURPOSE:To present the clinical characteristics of patients with anterior uveitis who had evidence of cytomegalovirus (CMV) infection on polymerase chain reaction PCR-based assays for viral DNA in aqueous samples. METHODS:This was a retrospective observational case series of 16 patients with CMV infection on qualitati...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.950384
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The most distinctive patterns of posterior pole affectation in syphilitic patients are acute posterior placoid chorioretinitis (ASPPC), pseudoretinitis pigmentosa and panuveitis with white focal preretinal opacities. However, outer retinitis is not a common presenting feature in this disease. CASE REPORT:...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1787464
更新日期:2020-07-23 00:00:00
abstract::The authors present a polymerase chain reaction method for rapid and direct diagnosis of herpetic intraocular infections using small volume samples of intraocular fluid from 29 patients with various intraocular inflammatory diseases and 24 controls with senile cataract. Of six patients with early acute retinal necrosi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949309086545
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To describe a case of orbital sarcoidosis manifesting with enophthalmos. METHODS:A 60-year-old woman presented with right enophthalmos. She had a palpable mass in her anterior orbit inferiorly. She underwent a complete ophthalmic evaluation, magnetic resonance imaging, and histopathologic examination. RESULTS...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940601038589
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:To determine the efficacy of interferon alpha 2b in the treatment of refractory, uveitic cystoid macular edema (CME). METHODS:Retrospective chart review of 4 patients attending the uveitis clinic at the Casey Eye Institute, Oregon Health & Science University. RESULTS:All 4 patients had uveitis and refractory ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2011.645989
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:The purpose of our study was to evaluate the potential efficacy and safety of intravitreal ranibizumab in patients with pseudophakic cystoid macular edema (CME). METHODS:This retrospective study comprised 7 eyes with CME treated with intravitreal ranibizumab. Patients were examined at 1 week and 1 month after ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.898775
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To compare clinical characteristics and visual prognosis between HLA-B27-associated uveitis patients with and without posterior segment involvement. METHODS:Medical records of 78 patients with HLA-B27-associated uveitis were retrospectively analyzed. RESULTS:Neither demographic nor clinical characteristics we...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802553261
更新日期:2009-01-01 00:00:00
abstract::Purpose: To describe the long-term clinical outcomes in a cohort of uveitic eyes treated with the intravitreal dexamethasone implant (Ozurdex; Allergan, Inc).Methods: Seventy-nine (63 patients) receiving 134 implant injections over 82 months were included. Indication, visual acuity (VA), intraocular pressure (IOP), vi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1578380
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:Longitudinal evaluation of acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) following diagnosis and treatment of metastatic melanoma. METHODS:Case report of a 47-year-old male with unknown primary metastatic melanoma and AEPPVM monitored before and during melanoma treatment using cl...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1813782
更新日期:2020-10-06 00:00:00
abstract:PURPOSE:To report a case of subretinal fibrosis and uveitis syndrome in association with ectodermal dysplasia. METHODS:Chart review of a patient with subretinal fibrosis and uveitis syndrome and ectodermal dysplasia. RESULTS:The authors identified one case of a patient with the diagnoses of subretinal fibrosis and uv...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903168670
更新日期:2009-09-01 00:00:00
abstract::The effects of tachykinins on prostaglandin E2 (PGE2)-induced intraocular inflammation were investigated. PGE2 (0.01% or 0.1%) instillation induced iridal hyperemia and protein leakage into the aqueous humor in rabbits, but caused minimal miosis. Intravitreally injected substance P (SP) or neurokinin A (NKA), on the o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.6.1.19.8080
更新日期:1998-03-01 00:00:00
abstract:PURPOSE:To report the outcomes of cataract surgery in ocular cicatricial pemphigoid (OCP). SETTING:L. V. Prasad Eye Institute, Hyderabad, India. DESIGN:Retrospective, interventional case series. METHODS:Patients diagnosed with OCP who had undergone cataract surgery were included. Staging of disease, type of surgery,...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.819106
更新日期:2013-12-01 00:00:00
abstract::Acute anterior uveitis (AAU) is the commonest type of uveitis and HLA-B27 AAU is the most frequently recognized type of acute anterior uveitis and anterior uveitis overall. Recent evidence indicates that acute anterior uveitis is a heterogenous disease, is polygenic and is frequently associated with the spondyloarthro...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.3109/09273948.2016.1158283
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To determine the prevalence of ocular involvement in patients with acute disseminated tuberculosis and to assess the findings associated with ocular involvement. METHODS:Assessment of all intensive care (ICU) admissions with a differential diagnosis of mycobacterial sepsis during a period of one year, with a d...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/092739490500354
更新日期:2004-12-01 00:00:00
abstract::Aims: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients.Methods: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for ≥12 months since acute dise...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1668431
更新日期:2019-10-31 00:00:00
abstract::Since experimental, herpes simplex virus-induced acute retinal necrosis (ARN) develops in mice only if the mice fail to acquire virus-specific delayed hypersensitivity (DH) and despite their production of anti-viral antibodies (i.e. ACAID), I investigated whether a similar situation exists for patients with either var...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.12.1.17.28066
更新日期:2004-03-01 00:00:00
abstract:PURPOSE:To describe whole-body 18-fluorodeoxyglucose (FDG) positron emission tomography/computed radiographic tomography (PET-CT) imaging of ophthalmic patients with systemic sarcoidosis. METHODS:Four systemic sarcoidosis patients were evaluated with PET-CT for staging. Two had been treated for conjunctival melanoma a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802596567
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:The authors report a case of a 60-year-old Caucasian male with a background of treated Chronic Lymphocytic Leukaemia (CLL) with secondary hypogammaglobulinaemia present with toxoplasma chorioretinitis and negative serum toxoplasma serology on presentation and on subsequent reactivation. METHODS:Retrospective c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1332769
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS:The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1247871
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:An HLA-DQ1 association has been suspected in patients who develop Propionibacterium acnes endophthalmitis following cataract surgery. New techniques exist which may help to define this association. MATERIALS AND METHODS:Patients with culture-proven P. acnes endophthalmitis following cataract surgery were HL...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949609069124
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To report a case of ocular Gnathostomiasis presenting as branch retinal artery occlusion. METHOD:Observational case report. RESULT:A 22-year-old Asian woman presented to her ophthalmologist with redness, tearing, and decreased vision in her left eye. Examination revealed anterior uveitis and branch retinal ar...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1820532
更新日期:2020-09-29 00:00:00
abstract::The eye is an immune-privileged site that uses specialized mechanisms to protect itself from damage and to preserve its visual acuity. Among the mechanisms that contribute to the eye's privileged existence is its ability to induce both local and peripheral tolerance to antigens that may transgress its chambers. Experi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273940490912371
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. METHODS:Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy. RESULTS:Seven eyes of four patients w...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1335756
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To compare levels of selected mediators in serums and aqueous humor (AH) of type 2 diabetes mellitus cataract patients with senile cataract patients, and to determine their association with postoperative corneal edema (CE). METHODS:Patients (32 senile and 29 diabetic cataract) undergoing standardized phacoemul...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.949779
更新日期:2016-01-01 00:00:00
abstract::Purpose: To present the ocular findings of the members of a family that has the diagnosis of Muckle Wells syndrome, a form of cryopyrin associated periodic syndrome (CAPS).Materials and Methods: Nine patients with MWS were included in this study. Each study participant underwent a systemic evaluation, comprehensive op...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1552305
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate serum inflammatory factors in patients with idiopathic choroidal vascularization (CNV), including vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNFα), Interleukin1-beta (IL1-β), IgG, IgA, IgM, IgE, 50% hemolytic unit of complement (CH50), complement C3, complement C4 a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2010.483315
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To describe the formation of a retinal pigment epithelial (RPE) tear following immunosuppressive treatment of a large choroidal granuloma in a patient with sarcoidosis-related panuveitis. METHODS:A 25-year-old woman presented with bilateral sarcoidosis-related panuveitis and optic disc edema in both eyes with ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1180402
更新日期:2017-12-01 00:00:00
abstract::Purpose: To review early withdrawal of immunomodulatory therapy (IMT) for birdshot retinochoroidopathy (BSRC). Design: Retrospective case-series of sixteen patients with Human-leukocyte-antigen-A29-positive BSRC treated with IMT ≥ 1 year and discontinued prior to achieving durable remission, observed ≥ 6 months off IM...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1506040
更新日期:2019-01-01 00:00:00
abstract::Several subjective and arbitrary grading methods are used in assessing cell and flare in uveitis. Clinicians are in need of an objective method of determining and monitoring active inflammation. We studied the correlation of changes in macular thickness between the visits and compared the change to visual acuity (VA),...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802702587
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To describe an unusual manifestation of sarcoidosis as a large tumor of the iris and ciliary body without any other involvement of the body. METHODS:We describe a 20-year-old female presenting with a granulomatous tumor of the right iris and ciliary body and concomitant uveitis. RESULTS:Extensive ocular and s...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/092739490500156
更新日期:2004-09-01 00:00:00