Macular Abnormalities in Vogt-Koyanagi-Harada Disease.

Abstract:

:Purpose: To investigate the prevalence of macular abnormalities in Chinese Vogt-Koyanagi-Harada (VKH) patients.Methods: Clinical characteristics, therapeutic effectiveness and visual outcome were reviewed and analyzed.Results: The most common macular abnormality was macular edema (ME), followed by macular choroidal neovascularization (CNV). Macular abnormalities were associated with recurrent episodes, disease course and visual acuity ≤20/50 at first visit. The prevalence of macular abnormalities in patients who were not treated according to our regular treatment regimen with corticosteroids combined with immunosuppressive agents and who were followed-up for at least one year (13.1%) was significantly higher than in patients receiving the regular treatment (5.7%). Visual improvement was found in 66.7% of eyes with macular abnormalities after regular treatment.Conclusion: Macular abnormalities were associated with recurrent uveitis, course of disease and lower visual acuity at first visit. Regular treatment could prevent the development of macular abnormalities and improved visual outcome in most patients.

journal_name

Ocul Immunol Inflamm

authors

Yang P,Ye Z,Xu J,Du L,Zhou Q,Qi J,Liang L,Wang C,Zhou C,Cao Q,Wu L,Kijlstra A

doi

10.1080/09273948.2019.1624781

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1195-1202

issue

8

eissn

0927-3948

issn

1744-5078

journal_volume

27

pub_type

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