Abstract:
:We determined the referral pattern and visual prognosis for patients with uveitis at a tertiary university eye center in the Midwestern U.S. over a five-year period. A retrospective chart review was conducted on 853 patients seen in the Department of Ophthalmology and Visual Sciences (DOVS) at Washington University and the Barnes Retina Institute (BRI) from 1990 to 1995. Recorded data on each patient included demographic information, anatomic diagnosis, etiologic diagnosis, pattern of uveitis, and best-corrected visual acuity (VA). Most patients originated from Missouri (65.3% [557/853]) and were Caucasian (88.4% [754/853]). There was an equal gender frequency (429 men, 424 women). The most frequent anatomic diagnosis was posterior uveitis (48.4% [414/853]), followed by anterior uveitis (22.3% [190/853]), panuveitis (18.4% [155/853]), and intermediate uveitis (10.9% [94/853]). An etiologic diagnosis was made in 69.3% (591/853) of the patients, with the most common diseases being cytomegalovirus (CMV) retinopathy, infectious endophthalmitis, pars planitis, multifocal choroiditis, and toxoplasmosis. The majority of uveitides presented with sudden onset (55.0% [469/853]) and lasted less than three months (51.9% [443/853]). A wide spectrum of uveitic disease is seen in a university eye center in the Midwest, including many cases with sudden-onset relatively short (<3 months) duration. The high frequency of posterior uveitis may be related to the appearance of newly recognized uveitic entities, such as multifocal choroiditis, birdshot retinochoroidopathy, and acute retinal necrosis.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Oruc S,Kaplan AD,Galen M,Kaplan HJdoi
10.1076/ocii.11.4.287.18270subject
Has Abstractpub_date
2003-12-01 00:00:00pages
287-98issue
4eissn
0927-3948issn
1744-5078journal_volume
11pub_type
杂志文章abstract:BACKGROUND:To evaluate the safety and efficacy of intravitreal triamcinolone acetonide (TA) for treating macular edema secondary to non-infectious uveitis. METHODS:Retrospective review of sixteen patients (20 eyes) with chronic cystoid macular edema (CME) as a consequence of controlled intermediate uveitis, posterior ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940590933511
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:ICON is a fusion protein composed of factor VII, the natural ligand for tissue factor, conjugated to the Fc domain of a human IgG1 immunoglobulin. It binds to the tissue factor expressed on neovascular endothelia and initiates a cytolytic immune attack that destroys the neovascular tissue. We previously showed ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940601147760
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To describe whole-body 18-fluorodeoxyglucose (FDG) positron emission tomography/computed radiographic tomography (PET-CT) imaging of ophthalmic patients with systemic sarcoidosis. METHODS:Four systemic sarcoidosis patients were evaluated with PET-CT for staging. Two had been treated for conjunctival melanoma a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802596567
更新日期:2009-03-01 00:00:00
abstract::In eyes with suspected endophthalmitis, early diagnosis and appropriate treatment have been noted to be associated with a better visual outcome. Currently, however, confirmation of the diagnosis of endophthalmitis (bacterial and/or fungal) is dependent on conventional techniques of microbiological isolation of organis...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:
更新日期:2000-09-01 00:00:00
abstract:UNLABELLED:Abstract Purpose: To characterize and analyze ocular involvement associated with visual loss in a cohort of patients with rickettsial disease. METHODS:Retrospective study of 16 eyes of 14 patients. RESULTS:Mean initial visual acuity (VA) was 20/63 (range, 20/800-20/25). White retinal lesions infiltrating i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.848907
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To assess correlation for anterior chamber flare grading between clinicians with different levels of experience and with semi-automated flare reading in a cohort of patients with heterogeneous uveitic entities. METHODS:Fifty-nine observations from 36 patients were recorded and analyzed for statistical associat...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.990042
更新日期:2016-01-01 00:00:00
abstract::Anterior uveitis is far more common than intermediate, posterior or panuveitis. About 50% of patients with acute anterior uveitis are HLA B27+. Those who are HLA B27+ are highly likely to have associated back, joint, or tendon disease. The majority of patients with acute anterior uveitis and inflammatory low back pain...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.3109/09273948.2016.1158277
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To compare the contamination rate between 27-gauge and 30-guage needles used for intravitreal injection (IVT). METHODS:Patients undergoing IVT injections were enrolled prospectively. Injections were performed with 27- or 30-gauge needles. All needle tips were collected and placed in brain-heart infusion broth....
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.801988
更新日期:2013-10-01 00:00:00
abstract::Scleritis is a severe and destructive inflammatory eye disease characterized by extensive extracellular matrix degradation. As in rheumatoid arthritis (RA), tissue destruction in scleritis may be mediated in part by matrix metalloproteinases such as collagenase (MMP-1) and stromelysin (MMP-3) which are normally kept i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949509069111
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:The authors report a case of a 60-year-old Caucasian male with a background of treated Chronic Lymphocytic Leukaemia (CLL) with secondary hypogammaglobulinaemia present with toxoplasma chorioretinitis and negative serum toxoplasma serology on presentation and on subsequent reactivation. METHODS:Retrospective c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1332769
更新日期:2018-01-01 00:00:00
abstract::Acute anterior uveitis (AAU) is the commonest type of uveitis and HLA-B27 AAU is the most frequently recognized type of acute anterior uveitis and anterior uveitis overall. Recent evidence indicates that acute anterior uveitis is a heterogenous disease, is polygenic and is frequently associated with the spondyloarthro...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.3109/09273948.2016.1158283
更新日期:2016-08-01 00:00:00
abstract::Aim: To analyze the incidence, microbiological profile, risk factors, and outcomes in eyes with osteo-odonto keratoprosthesis (OOKP) developing endophthalmitis. Methods & material: Retrospective review of medical records of patients presenting between 2003 and 2013 with OOKP and endophthalmitis was undertaken after ob...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770807
更新日期:2020-10-07 00:00:00
abstract::Purpose: To review the broad spectrum of clinical neuro-ophthalmic presentations associated with human immunodeficiency virus (HIV) infection. Methods: Critical review of the literature regarding neuro-ophthalmic consequences of HIV infection and its sequelae. Results: Neuro-ophthalmological diseases are common in bot...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1704024
更新日期:2020-10-02 00:00:00
abstract::Onchocercal keratitis (river blindness) is one of the leading worldwide causes of blindness. Light microscopic analysis of human specimens and corneal tissue from experimental models has implicated the eosinophil as an important cell in the inflammatory response. Our previous studies in experimental murine onchocercal...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949709116890
更新日期:1997-09-01 00:00:00
abstract::Purpose: To determine the anti-inflammatory effects of dehydroxymethylepoxyquinomicin (DHMEQ), a nuclear factor-κB (NF-κB) inhibitor, on endotoxin-induced uveitis (EIU) in rats.Methods: EIU was induced by a subcutaneous injection of lipopolysaccharide (LPS) in Lewis rats. DHMEQ was injected intraperitoneally concurren...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1568502
更新日期:2020-01-01 00:00:00
abstract::Purpose: To compare the clinical characteristics of patients with active episodes of ocular toxoplasmosis from three provinces, Misiones, Santa Fe, and Buenos Aires, Argentina. Methods: Patients with a diagnosis of ocular toxoplasmosis from three databases of four tertiary referral uveitis centers were reviewed. Colle...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1484494
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To compare Behçet uveitis patients who presented in the 1990s and 2000s. METHODS:Records of 170 patients seen in 1990-1994 and 258 patients seen in 2000-2004 were reviewed. Presenting features were analyzed in the whole cohort. Uveitis attacks, vision, complications, and immunomodulatory treatment (IMT) were c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2012.713159
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:Tear lysozyme and tear lactoferrin are enzymes synthesized by the lacrimal gland. Their concentration in human tears reflects tear gland function. Tear gland dysfunction can lead to ocular surface disease. We developed a colorimetric lysozyme assay. The objective of this study was to determine the diagnostic po...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.7.1.7.8108
更新日期:1999-03-01 00:00:00
abstract::The standardization of Uveitis Nomenclature (SUN) Working Group recently affirmed the importance of an anatomic classification of uveitis, endorsing the anatomic clasiffication scheme proposed by the International Uveitis Study Group (IUSG). The group however pointed out and addressed ambiguities in the IUSG system, a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903348835
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To describe demographic features and clinical and imaging characteristics of inflammatory choroidal neovascularization (CNV) in a Chinese population. METHODS:A retrospective case review of patients with CNV secondary to uveitis from 2002 to 2013. RESULTS:A total of 125 patients (150 eyes, 166 CNVs; bifocal CN...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1015741
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To report a case of acute retinal necrosis (ARN) occurring in the opposite eye to the ophthalmic shingles eruption. DESIGN:Case report. METHODS:Clinical examination and multimodal imaging review, including ultra-widefield photography and fluorescein angiography (FA). RESULTS:A 49-years-old man attended the U...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770298
更新日期:2020-07-09 00:00:00
abstract:PURPOSE:To evaluate morphology of the optic nerve head and visual field in AIDS patients without retinitis. METHODS:One randomly selected eye from 246 patients with AIDS without retinitis was evaluated from prospective multicenter Longitudinal Studies of Ocular Complications of AIDS. Stereo fundus photographs of OHN a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/09273948.2012.694552
更新日期:2012-10-01 00:00:00
abstract::Several subjective and arbitrary grading methods are used in assessing cell and flare in uveitis. Clinicians are in need of an objective method of determining and monitoring active inflammation. We studied the correlation of changes in macular thickness between the visits and compared the change to visual acuity (VA),...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802702587
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To investigate clinical findings and ocular characteristics of sterile endophthalmitis following intravitreal injection (IVI) of triamcinolone for the treatment of macular edema. METHODS:IVI is an institutional practice at our hospital. From March 2002 to January 2003, a total of 21 IVIs of triamcinolone aceto...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940590951007
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:To compare levels of selected mediators in serums and aqueous humor (AH) of type 2 diabetes mellitus cataract patients with senile cataract patients, and to determine their association with postoperative corneal edema (CE). METHODS:Patients (32 senile and 29 diabetic cataract) undergoing standardized phacoemul...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.949779
更新日期:2016-01-01 00:00:00
abstract::Herpes simplex virus, varicella zoster virus, human cytomegalovirus, and rubella virus are the most common causes of virus-induced anterior uveitis. They can present in a variety of entities not only with typical but also overlapping clinical characteristics. These viral infections are commonly associated with ocular ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2018.1439069
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To assess long-term efficacy and safety of infliximab for refractory Behçet disease (BD) uveitis and to evaluate the effect of withdrawal of infliximab after achieving long-term remission. METHODS:Retrospective study of 19 patients. RESULTS:Mean follow-up was 44.1 ± 36.5 months and mean number of infliximab i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.779727
更新日期:2013-12-01 00:00:00
abstract::Introduction: Uveitic macular edema (UME) is a significant cause of visual impairment in all uveitis types. Methods: Reports that were cited in the MEDLINE database, that analyzed the effectiveness of biologics for UME in at least five patients, with a minimum follow-up of 3 months, published prior to April 1, 2019 we...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1709648
更新日期:2020-11-16 00:00:00
abstract:OBJECTIVE:To report a case of toxic anterior uveitis probably secondary to the use of topical podophyllum. DESIGN:Case report, interventional. METHODS:The authors present a 78-year-old male with acute anterior uveitis that developed within a couple of hours of application of topical podophyllum. In vivo confocal micr...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2010.551446
更新日期:2011-04-01 00:00:00
abstract::Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2016.1231332
更新日期:2017-02-01 00:00:00