Abstract:
:Onchocercal keratitis (river blindness) is one of the leading worldwide causes of blindness. Light microscopic analysis of human specimens and corneal tissue from experimental models has implicated the eosinophil as an important cell in the inflammatory response. Our previous studies in experimental murine onchocercal keratitis have demonstrated that the inflammatory infiltrate is composed primarily of eosinophils displaying ring shaped or bilobed nuclei. However, a number of cells were not characterizable by light microscopy, presumably due to mechanical distortion. To more fully characterize the inflammatory cell infiltrate, we examined corneal specimens by transmission electron microscopy. In addition to typical eosinophils with bilobed and ring shaped nuclei, this approach revealed cells with variable nuclear morphology and cell shape which contained the dense cored granules characteristic of eosinophils. Hence, the degree of pleomorphism of eosinophils is broader than appreciated and underscores the importance of this cell in experimental murine onchocercal keratitis.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Bardenstein DS,Lass JH,Kazura JW,Pearlman Edoi
10.3109/09273949709116890subject
Has Abstractpub_date
1997-09-01 00:00:00pages
157-63issue
3eissn
0927-3948issn
1744-5078journal_volume
5pub_type
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journal_title:Ocular immunology and inflammation
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journal_title:Ocular immunology and inflammation
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