Pleomorphism of stromal eosinophils in murine experimental onchocercal keratitis.

Abstract:

:Onchocercal keratitis (river blindness) is one of the leading worldwide causes of blindness. Light microscopic analysis of human specimens and corneal tissue from experimental models has implicated the eosinophil as an important cell in the inflammatory response. Our previous studies in experimental murine onchocercal keratitis have demonstrated that the inflammatory infiltrate is composed primarily of eosinophils displaying ring shaped or bilobed nuclei. However, a number of cells were not characterizable by light microscopy, presumably due to mechanical distortion. To more fully characterize the inflammatory cell infiltrate, we examined corneal specimens by transmission electron microscopy. In addition to typical eosinophils with bilobed and ring shaped nuclei, this approach revealed cells with variable nuclear morphology and cell shape which contained the dense cored granules characteristic of eosinophils. Hence, the degree of pleomorphism of eosinophils is broader than appreciated and underscores the importance of this cell in experimental murine onchocercal keratitis.

journal_name

Ocul Immunol Inflamm

authors

Bardenstein DS,Lass JH,Kazura JW,Pearlman E

doi

10.3109/09273949709116890

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

157-63

issue

3

eissn

0927-3948

issn

1744-5078

journal_volume

5

pub_type

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